Chemical Composition, Antifungal, and Cytotoxic Activities of Essential Oil From Brunfelsia uniflora Leaves
Chemistry & Biodiversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
This
study
aimed
to
determine
the
phytochemical
composition
of
essential
oil
(EO)
from
Brunfelsia
uniflora
leaves
and
evaluate
its
antifungal
cytotoxic
activities.
The
EO
was
obtained
by
hydrodistillation
analyzed
using
GC-MS
GC-FID,
leading
identification
39
compounds.
predominantly
terpenoid
(65.7%),
followed
non-terpenoid
constituents
(31.2%).
major
compounds
identified
included
phytol
(13.2%),
oleic
acid
(10.5%),
phenylethyl
alcohol
(9.2%),
γ-eudesmol
acetate
(7.0%).
activity
evaluated
against
Candida
species
broth
microdilution
method.
exhibited
strong
inhibitory
effects
C.
albicans
orthopsilosis
(MIC
=
62.5
µg/mL),
moderate
glabrata
rugosa
250
weak
tropicalis
1000
µg/mL).
were
assessed
in
human
tumor
cell
lines
(HeLa,
MCF-7)
a
nontumor
fibroblast
line
(GM07492A).
demonstrated
selective
cytotoxicity
toward
HeLa
(IC50
21.9
µg/mL)
MCF-7
25.7
while
exhibiting
lower
toxicity
fibroblasts
131.9
selectivity
indices
(SI
6.0
for
HeLa,
5.1
suggest
potential
as
promising
therapeutic
candidate
anticancer
applications.
Язык: Английский
Synthesis, molecular docking simulation, and antimicrobial activities of novel fused pyrimidine systems linked to N-arylacetamide and vanillin units as novel hybrid molecules via Hantzsch and Biginelli reactions
Journal of Molecular Structure,
Год журнала:
2025,
Номер
unknown, С. 142345 - 142345
Опубликована: Апрель 1, 2025
Язык: Английский