Similarly
to
a
phoenix,
SARS-CoV-2
has
appeared
periodically
in
waves.
The
new
variants
that
through
mutations
have
during
the
4
years
of
pandemic
suppressed
earlier
variants,
causing
waves
pandemic.
Omicron
BA.2.86
Pirola
variant
is
latest
sequence
which
2023.
started
spread
rapidly
and
we
are
witnesses
epidemic
wave.
In
this
short
period,
an
increased
infectivity
was
noticed,
results
rapid
spreading
decreased
pathogenicity,
lower
number
severe
cases.
However,
public
there
fear
further
development
epidemic.
This
analysis
made
with
goal
assess
risks
period
late
Mutations
were
developed
by
led
change
empirical
formula
thermodynamic
properties.
It
seems
no
ground
for
extensive
forms,
but
reasons
caution
monitoring
potential
appearance
mutations.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2023,
Номер
42(19), С. 10388 - 10400
Опубликована: Сен. 11, 2023
Insulin
was
discovered
100
years
ago
and
has
been
well
studied
from
the
perspectives
of
life
biomedical
sciences.
This
paper
reports
chemical
biothermodynamic
properties
biosynthesis
insulin.
for
first
time
molecular
empirical
formulas,
reactions,
thermodynamic
molecules
their
human
preproinsulin,
proinsulin,
insulin
chain
A,
B,
insulin,
signal
peptide
intermediate
(C-peptide).
Based
on
these,
metabolic
reactions
were
formulated
conversion
preproinsulin
to
feasibility
analyzed.Communicated
by
Ramaswamy
H.
Sarma.
Pharmacology Research & Perspectives,
Год журнала:
2024,
Номер
12(4)
Опубликована: Июль 9, 2024
Abstract
We
hypothesize
that
a
“Faustian
bargain”—the
trading
of
increased
SARS—CoV2
viral
infection
with
concurrent
potential
for
prevention
life‐threatening
lower
lung
explains
the
previous
and
future
morbidity
mortality
from
COVID‐19.
Further,
this
trade‐off
is
made
feasible
by
fundamental
principles
thermodynamics
receptor
affinity.
Journal of the Serbian Chemical Society,
Год журнала:
2024,
Номер
89(6), С. 807 - 822
Опубликована: Янв. 1, 2024
Similarly
to
a
phoenix,
SARS-CoV-2
has
appeared
periodically
in
waves.
The
new
variants
that
through
mutations
have
suppressed
earlier
variants,
causing
waves
of
the
pandemic.
Omicron
BA.2.86
Pirola
variant
is
latest
sequence.
An
increased
infectivity
was
noticed,
which
results
rapid
spreading,
as
well
decreased
pathogenicity,
lower
number
severe
cases.
However,
public
there
fear
further
development
epidemic.
This
analysis
made
with
goal
assess
risks
period
early
2024.
Mutations
were
developed
by
led
change
empirical
formula
and
thermodynamic
properties.
virus
particle
CH1.639023O0.284130N0.230031P0.006440S0.003765.
It
different
than
those
other
SARS-CoV-2,
species
cellular
organisms.
driving
force
for
multiplication,
Gibbs
energy
biosynthesis
?221.75
kJ
C-mol-1.
more
negative
its
host
tissue.
According
phenomenological
equation,
allows
achieve
greater
rate
hijack
cell
metabolism.
similar
CH.1.1
XBB.1.16
variants.
means
these
should
multiplication
rates
thus
pathogenicity.
Therefore,
it
seems
no
ground
an
extensive
spreading
forms,
but
are
reasons
caution
monitoring
epidemic
potential
appearance
mutations.
Moreover,
unlike
pandemic
waves,
during
newest
wave,
infections
influenza,
RSV
simultaneously
appeared,
deserves
analysis.
Thermal Science,
Год журнала:
2024,
Номер
28(6 Part A), С. 4737 - 4757
Опубликована: Янв. 1, 2024
Coxsackievirus
B
represents
a
nightmare
for
large
number
of
medical
staff.
Due
to
exposure
in
closed
spaces
(ambulances
and
waiting
rooms),
infections
by
are
common
occurrence.
This
paper
the
first
time
reports
chemical
thermodynamic
properties
Coxsackieviruses
A
B,
offers
mechanistic
model
Coxsackievirus-host
interaction.
The
driving
force
interaction
at
membrane
(antigen-receptor
binding)
is
Gibbs
energy
binding.
virus-host
cytoplasm
biosynthesis.
analyzes
mechanism
hijacking
cell
metabolic
machinery
susceptible
cells.
Thermal Science,
Год журнала:
2023,
Номер
27(6 Part B), С. 4893 - 4910
Опубликована: Янв. 1, 2023
Biothermodynamics
is
a
discipline
which
has
developed
intensely
during
the
last
50
years.
Thermodynamic
properties
have
been
reported
for
humans,
animals,
plants,
and
microorganisms.
However,
this
paper
reports
first
time
empirical
formula
thermodynamic
insects.
can
be
applied
in
research
on
interactions
between
organisms
their
environment,
as
well
themselves.
This
reactions
of
catabolism,
biosynthesis
entire
metabolism
Bombyx
mori
(domestic
silk
moth),
mori.
It
shown
that
growth
tightly
related
to
catabolism
carbohydrates
lipids,
represents
driving
force
metabolism.
