The Medical and Ecological Problems,
Год журнала:
2024,
Номер
28(3), С. 42 - 60
Опубликована: Дек. 30, 2024
Airborne
microplastic
(NP)
and
nanoplastic
(MP)
pollution
has
emerged
as
a
pressing
environmental
concern
with
significant
implications
for
human
health.
While
MPs
are
present
both
indoors
outdoors,
indoor
concentrations
generally
higher
due
to
the
abrasion
of
household
materials,
furniture,
other
domestic
sources.
NPs,
when
inhaled,
accumulate
in
various
lung
regions,
exerting
toxic
effects
potentially
leading
respiratory
diseases.
This
systematic
review,
conducted
according
PRISMA
guidelines,
evaluates
recent
experimental
studies
on
pathogenic
impact
nanomicroplastics
(NMPs)
tissues
using
vivo
vitro
models.
The
review
included
10
analyzing
MP
accumulation
90
examining
pathogenetic
mechanisms
exposure.
Research
data
indicates
predominance
polymeric
fibers
such
polypropylene,
polyethylene
terephthalate,
polytetrafluoroethylene,
accounting
nearly
half
structures.
NMPs
exhibit
size-
composition-dependent
accumulation,
smaller
positively
charged
particles
showing
translocation
potential
systemic
circulation
organs.
highlights
synergistic
heavy
metals
pollutants,
interaction
pulmonary
surfactant,
role
exacerbating
Current
analysis
underscores
growing
interest
NMP-related
health
risks
identifies
knowledge
gaps,
including
need
standardization
NMP
toxicity
testing
further
exploration
biological
systems.
findings
emphasize
importance
mitigating
exposure
safeguard
pave
way
future
research
long-term
impacts
airborne
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
469, С. 134030 - 134030
Опубликована: Март 13, 2024
Continuous
exposure
to
plastic
pollutants
may
have
serious
consequences
on
human
health.
However,
most
toxicity
assessments
focus
non-environmentally
relevant
particles
and
rarely
investigate
long-term
effects
such
as
cancer
induction.
The
present
study
assessed
the
carcinogenic
potential
of
two
secondary
nanoplastics:
polyethylene
terephthalate
(PET)
generated
from
bottles,
a
biodegradable
polylactic
acid
material,
respective
examples
environmentally
existing
new
bioplastics.
Pristine
polystyrene
nanoplastics
were
also
included
for
comparison.
A
broad
concentration
range
(6.25
–
200
μg/mL)
each
nanoplastic
was
tested
in
both
initiation
promotion
conditions
regulatory
assessment-accepted
vitro
Bhas
42
cell
transformation
assay.
Parallel
cultures
allowed
confirmation
efficient
cellular
internalisation
three
nanoplastics.
Cell
growth
enhanced
by
assay,
PET
conditions.
Moreover,
number
transformed
foci
significantly
increased
only
highest
which
showed
dose-dependency,
indicating
that
nano
can
act
non-genotoxic
tumour
promotor.
Together,
these
findings
support
risk
assessment
raise
concerns
regarding
whether
real-life
co-exposure
other
environmental
result
synergistic
capacities.
Secondary
(NPLs)
waste
degradation
bioaccumulate
tissues
cause
cancer.
Currently,
information
NPL
carcinogenicity
remains
scarce.
By
using
we
first
time
NPLs,
bioplastic,
widely
spread
petroleum-based
alternative,
respectively.
Notably,
accelerated
bioplastics
has
been
associated
with
an
release
NPLs
into
environment.
data
will
serve
plastics.
Journal of Applied Toxicology,
Год журнала:
2024,
Номер
44(11), С. 1657 - 1678
Опубликована: Март 17, 2024
Abstract
Plastic
waste
comprises
polymers
of
different
chemicals
that
disintegrate
into
nanoplastic
particles
(NPLs)
1–100‐nm
size,
thereby
littering
the
environment
and
posing
a
threat
to
wildlife
human
health.
Research
on
NPL
contamination
has
up
now
focused
ecotoxicology
effects
pollution
rather
than
health
risks.
This
review
aimed
speculate
about
possible
properties
carcinogenic
neurotoxic
as
pollutants.
Given
their
low‐dimensional
size
high
surface
ratio,
NPLs
can
easily
penetrate
biological
membranes
cause
functional
structural
damage
in
cells.
Once
inside
cell,
interrupt
autophagy
flux
cellular
debris,
alter
proteostasis,
provoke
mitochondrial
dysfunctions,
induce
endoplasmic
reticulum
stress.
Harmful
metabolic
processes
induced
by
include
oxidative
stress
(OS),
ROS
generation,
pro‐inflammatory
reactions.
Depending
cell
cycle
status,
may
direct
DNA
damage,
tumorigenesis,
lately
carcinogenesis
tissues
with
self‐renewal
capabilities
like
epithelia.
In
cells
able
live
longest
neurons,
could
trigger
neurodegeneration
promoting
toxic
proteinaceous
aggregates,
OS,
chronic
inflammation.
genotoxicity
neurotoxicity
are
discussed
based
gathered
evidence,
when
available,
within
context
intracellular
uptake
these
newcomer
nanoparticles.
summary,
this
explains
how
risk
evaluation
for
benefit
from
accurately
monitoring
toxicokinetics
toxicodynamics
at
resolution
level.
Nanomaterials,
Год журнала:
2024,
Номер
14(9), С. 807 - 807
Опубликована: Май 6, 2024
Micro-
and
nanoplastics
(MNPs)
have
become
ubiquitous
contaminants
of
water
foods,
resulting
in
high
levels
human
ingestion
exposure.
MNPs
been
found
blood
multiple
tissues,
suggesting
that
they
are
readily
absorbed
by
the
gastrointestinal
tract
(GIT)
widely
distributed.
Growing
toxicological
evidence
suggests
ingested
may
pose
a
serious
health
threat.
The
potential
genotoxicity
MNPs,
however,
remains
largely
unknown.
In
this
study,
primary
environmentally
relevant
secondary
was
assessed
triculture
small
intestinal
epithelium
(SIE)
model
using
CometChip
assay.
Aqueous
suspensions
25
1000
nm
carboxylated
polystyrene
spheres
(PS25C
PS1KC),
incinerated
polyethylene
(PEI
PM0.1)
were
subjected
to
simulated
GIT
digestion
create
physiologically
exposures
(digestas),
which
applied
SIE
at
final
MNP
concentrations
1,
5,
20
μg/mL
for
24
or
48
h.
PS25C
PS1KC
induced
DNA
damage
time-
concentration-dependent
manner.
To
our
knowledge,
is
one
first
assessment
an
integrated
vitro
platform
including
model.
These
findings
suggest
PS
could
genotoxic
consequences
SIE.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis,
Год журнала:
2025,
Номер
903, С. 503865 - 503865
Опубликована: Март 6, 2025
Plastic
is
used
extensively
worldwide.
However,
plastic
particles
that
are
less
than
1000
nm
(i.e.
nanoplastics)
may
be
hazardous
to
human
cells.
Nanoplastics
might
manufactured
intentionally
or
formed
in
the
environment
by
degradation
of
larger
items.
Ingestion
and
inhalation
two
most
common
routes
exposure
nanoplastics,
indicating
epithelial
cells
have
direct
exposure.
immune
will
also
interact
with
during
tissue
inflammation.
An
assessment
published
studies
suggests
polystyrene
(PS)
generate
higher
levels
DNA
damage
compared
cells,
although
it
has
not
been
formally
studied
under
same
experimental
condition.
To
investigate
this,
we
assessed
cytotoxicity,
oxidative
stress
strand
breaks
lung
(A549)
intestinal
(Caco-2)
monocytes
(THP-1
U937)
after
amine-functionalized
(PS-NH2)
declared
particle
size
240
nm.
No
cytotoxicity
intracellular
reactive
oxygen
species
production
were
found
at
concentrations
up
200
µg/mL.
Exposure
PS-NH2
was
associated
glutathione
depletion
A549
there
no
increase
level
breaks,
measured
comet
assay,
any
cell
lines
standard
assay
conditions.
Diethyl
maleate
treatment
render
susceptible
stress.
By
itself,
diethyl
led
approximately
50
%
increased
but
additional
observed
A549,
Caco-2,
THP-1
U937
