Fluorescein sodium as a marker for focused ultrasound-induced blood-brain barrier disruption: a case report in a porcine model DOI Creative Commons
Yuan Xu, Thomas J. On,

Mark C. Preul

и другие.

Frontiers in Surgery, Год журнала: 2025, Номер 12

Опубликована: Апрель 1, 2025

Transcranial low-intensity focused ultrasound (FUS) enables noninvasive, targeted, and reversible blood-brain barrier (BBB) disruption, facilitating drug delivery liquid biopsy of the brain. Using fluorescein sodium (FNa) with macroscopic widefield fluorescence microscopic confocal laser endomicroscopy (CLE) imaging, we assessed BBB permeability after applying a frameless, electromagnetic-guided FUS system in porcine model confirmed established MRI protocol conventional histology. Both FNa imaging findings correlated contrast-enhanced MRI, providing direct evidence disruption. This approach demonstrates utility for evaluating preclinical studies.

Язык: Английский

Fluorescein sodium as a marker for focused ultrasound-induced blood-brain barrier disruption: a case report in a porcine model DOI Creative Commons
Yuan Xu, Thomas J. On,

Mark C. Preul

и другие.

Frontiers in Surgery, Год журнала: 2025, Номер 12

Опубликована: Апрель 1, 2025

Transcranial low-intensity focused ultrasound (FUS) enables noninvasive, targeted, and reversible blood-brain barrier (BBB) disruption, facilitating drug delivery liquid biopsy of the brain. Using fluorescein sodium (FNa) with macroscopic widefield fluorescence microscopic confocal laser endomicroscopy (CLE) imaging, we assessed BBB permeability after applying a frameless, electromagnetic-guided FUS system in porcine model confirmed established MRI protocol conventional histology. Both FNa imaging findings correlated contrast-enhanced MRI, providing direct evidence disruption. This approach demonstrates utility for evaluating preclinical studies.

Язык: Английский

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