Impact of dance classes on motor and cognitive functions and gut microbiota composition in multiple sclerosis patients: Randomized controlled trial

European Journal of Sport Science, Год журнала: 2024, Номер 24(8), С. 1186 - 1196

Опубликована: Июль 5, 2024

Abstract Evidence suggests that multiple sclerosis (MS) induces a decline in motor and cognitive function provokes shift gut microbiome composition patients. Therefore, the aim of study was to explore effect dance classes on functions microbiota MS In this randomized controlled trial, 36 patients were randomly divided into two groups: experimental group ( n = 18) passive control 18). Supervised rock roll sports performed for 12 weeks at frequency times week. Before after intervention, fecal samples taken assessments completed. Fecal categorized using primers targeting V3–V4 region 16S rDNA. Our results revealed significant differences mobility performance (T25‐FWT), attention working memory (TMT B), finger dexterity (9‐HPT) within group. Furthermore, we reported favorable shifts microbial communities (an increase Blautia stercoris decrease Ruminococcus torques ) conclusion, our trial effects 12‐week found improvements functions, with further moderate influence composition.

Язык: Английский

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Conventional and Advanced Magnetic Resonance Imaging Biomarkers of Multiple Sclerosis in the Brain

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 2, 2025

Multiple sclerosis (MS) is a heterogeneous disease, and each MS patient exhibits different clinical symptoms that are reflected in their magnetic resonance imaging (MRI) results. Each lesion should be interpreted carefully evaluated conjunction with examination. MRI plays major role evaluating how lesions aggregated the central nervous system they change over time. There several conventional biomarkers of could utilized to evaluate phenotype. useful for decisions, aiding determination disease-modifying treatment or disease prognosis. Despite its higher sensitivity, provides low specificity due heterogeneity lesions. However, advanced show promise terms defining lesions, as biomarker correlates differently scenario The aim this review summarise current state brain relate neurological disabilities.

Язык: Английский

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Retrieval time analysis of triple advanced standard encryption in comparison with single data Encryption standard in content-based image retrieval secured cloud computing

AIP conference proceedings, Год журнала: 2025, Номер 3252, С. 020058 - 020058

Опубликована: Янв. 1, 2025

Язык: Английский

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Clinical and MRI features contributing to the clinico-radiological dissociation in a large cohort of people with multiple sclerosis

Journal of Neurology, Год журнала: 2025, Номер 272(5)

Опубликована: Апрель 9, 2025

Abstract Background People with Multiple Sclerosis (PwMS) often show a mismatch between disability and T2-hyperintense white matter (WM) lesion volume (LV), that in general is referred to as the clinico-radiological paradox. Objectives This study aimed understand how an extensive clinical, neuropsychological, MRI analysis could better elucidate dissociation large cohort of PwMS. Methods Clinical scores, such Expanded Disability Status Scale (EDSS), 9 Hole Peg Test (9HPT), 25-foot Walking (25-FWT), Paced Auditory Serial Addition at 3 s (PASAT3), Symbol digit Modalities (SDMT), demographics, T-MRI 717 PwMS 284 healthy subjects (HS) were downloaded from INNI database. Considering medians LV EDSS divided into four groups: low (LL/LD); high (HL/LD); (LL/HD); (HL/HD). measures included: volumes gray (GM), WM, cerebellum, basal ganglia thalamus, spinal cord (SC) area, functional connectivity resting-state networks. Results The involved 36% our sample. HL/LD showed worse SDMT scores lower global deep GM than HS LL/LD. LL/HD GM, cerebellum volumes, SC area HS, Conclusions A more clinical assessment, including cognitive tests, evaluation SC, describe real status disease help clinicians early tailored treatment

Язык: Английский

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Towards Longitudinal Characterization of Multiple Sclerosis Atrophy Employing SynthSeg Framework and Normative Modeling

Lecture notes in computer science, Год журнала: 2025, Номер unknown, С. 38 - 51

Опубликована: Янв. 1, 2025

Язык: Английский

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SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes lesion activity volumes following infection. Methods included 177 pwMS (570 MRI scans) diagnosed tested positive for between August 2020 May 2021. All were free clinical disease activity, disease‐modifying therapy changes, corticosteroids during the study. scans performed using a standardized protocol 3‐Tesla scanner. analyzed effect load accrual volume measures adjusted mixed‐effect models. Results During infection, had median duration 14.2 years, age 44.9 Expanded Disability Status Scale 2.0. did not lead any number or T1 T2 lesions brain. However, was associated an increased whole ( B = −0.17; SE 0.08; p 0.028), grey matter −0.25; 0.12; 0.040), cortical loss −0.32; 0.13; 0.014). Greater ventricular enlargement evident only individuals over 40 (interaction vs. enlargement: 0.17; 0.05; 0.0003). Only more severe showed reduction mean upper cervical area (MUCCA) 1.14; 0.52; 0.030). Interpretation clinically stable linked neuronal tissue loss.

Язык: Английский

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Volumetric and Asymmetric Index Analysis of Subcortical Structures in Multiple Sclerosis Patients: A Retrospective Study Using volBrain Software

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Март 8, 2024

Introduction Multiple sclerosis (MS) is a chronic and autoimmune disease that has significant influence on the central nervous system, such as brain spinal cord, affecting millions of individuals globally. Understanding connection between subcortical regions MS crucial for effective diagnostic therapeutic approaches treating this disabling disease. This study explores relationship volume contours asymmetry index in with using volBrain software (https://www.volbrain.net; developed by José V. Manjón (Valencia Polytechnic University, Valencia, Spain) Pierrick Coupé (University Bordeaux, France)). Methods In our retrospective investigation, we admitted 100 Turkish individuals, comprising 50 patients diagnosed relapsing-remitting (RRMS) (24 (48%) males 26 (52%) females) healthy controls (23 (46%) 27 (54%) females), registered October 2017 February 2022 five years underwent assessment radiology department at Teaching Research Hospital Kocaeli University; 1,150 were excluded from based exclusion criteria. We used magnetic resonance imaging 3-Tesla (3T) scanner to assess volumes (cm3) indexes due different levels atrophy total intracranial, brain, gray matter, white regions, most affected both patient control cohorts. Results Statistical analysis revealed difference groups (p < 0.001), group mean age 38.32 32.88 years. Patient exhibited lower values cerebrospinal fluid compared 0.05). The results indicated statistically decrease 0.05) intracranial volume, whereas all other remained unchanged. structures right left sides found putamen, thalamus, globus pallidus had than apart lateral ventricle. Furthermore, investigation demonstrated index, indicating preference A value signifies larger side when side. Conclusion Brain atrophy, although characterized irreversible tissue damage, targeted interventions prevent progression. It is, therefore, imperative develop universally accepted measurement standard also considers inherent variability present within each structure. Our findings serve an important basis indicator determination MS, prognosis disease, etiology clinical symptoms. Subsequent research may benefit adopting novel approach considering outcome rather predictor, thereby facilitating elucidation intricate biological mechanisms give rise loss.

Язык: Английский

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Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis

Multiple Sclerosis and Related Disorders, Год журнала: 2024, Номер 90, С. 105801 - 105801

Опубликована: Авг. 5, 2024

Язык: Английский

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Treatment Monitoring in Multiple Sclerosis — Efficacy and Safety

Neuroimaging Clinics of North America, Год журнала: 2024, Номер 34(3), С. 439 - 452

Опубликована: Апрель 29, 2024

Язык: Английский

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BrainLossNet: a fast, accurate and robust method to estimate brain volume loss from longitudinal MRI

International Journal of Computer Assisted Radiology and Surgery, Год журнала: 2024, Номер 19(9), С. 1763 - 1771

Опубликована: Июнь 16, 2024

Abstract Purpose MRI-derived brain volume loss (BVL) is widely used as neurodegeneration marker. SIENA state-of-the-art for BVL measurement, but limited by long computation time. Here we propose “BrainLossNet”, a convolutional neural network (CNN)-based method BVL-estimation. Methods BrainLossNet uses CNN-based non-linear registration of baseline(BL)/follow-up(FU) 3D-T1w-MRI pairs. computed parenchyma masks segmented in the BL/FU scans. The estimate corrected image distortions using apparent change total intracranial volume. was trained on 1525 pairs from 83 scanners. Agreement between and assessed 225 94 MS patients acquired with single scanner 268 52 scanners various indications. Robustness to short-term variability compared 354 healthy men same session without repositioning 116 (Frequently-Traveling-Human-Phantom dataset, FTHP). Results Processing time 2–3 min. median [interquartile range] SIENA-BrainLossNet difference 0.10% [− 0.18%, 0.35%] 0.08% 0.14%, 0.28%] indications dataset. distribution FTHP dataset narrower ( p = 0.036; 95th percentile: 0.20% vs 0.32%). Conclusion average provides estimates SIENA, it significantly more robust, probably due its built-in distortion correction. min makes suitable clinical routine. This can pave way widespread use estimation intra-scanner

Язык: Английский

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