Evaluation of patient-perceived fatigue in multiple sclerosis utilizing the Finnish MS registry

Multiple Sclerosis Journal - Experimental Translational and Clinical, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 1, 2025

To characterize patient-perceived fatigue by using the Finnish Multiple Sclerosis (MS) registry data. Fatigue was assessed with Severity Scale (FSS), for Motor and Cognitive Functions (FSMC), Visual Analogue Scale-Fatigue. Disease severity evaluated Expanded Disability Status symptoms Scales. Patient reported outcomes (PROs) included Neuropsychological Questionnaire, Euro Quality of Life - 5 dimensions, 15 D, Impact Scale. For purposes study, patients were classified to those without (FSS ≤ 4) ≥ 5) fatigue. The FSS scores correlated results other PROs. Based on 512 scores, 47% 5). related higher disability, lower education, smoking. significantly measures fatigue, cognitive, mood symptoms, associated Life. As an invisible debilitating symptom should be systematically. In screening, it is important recognize characteristics different scales. Whereas may serve as overall screen, FSMC help identify aspects cognitive motor separately.

Язык: Английский

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White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 12, 2025

Multiple sclerosis (MS) is a prevalent neurological disorder marked by inflammation and demyelination, with fatigue being one of the most reported debilitating symptoms. While occurs across various conditions even in healthy individuals, specific mechanisms contributing to each context remain unclear. In this study, we conducted cross-sectional analysis involving 32 people relapsing MS (PwRMS) 29 controls who fatigue. Participants underwent MRI scans, including T1-weighted diffusion-weighted imaging. Additionally, Modified Fatigue Impact Scale was utilized. We employed Bayesian LASSO Spike-and-Slab regression models investigate hypothesis that correlates differently brain structures PwRMS. Our findings revealed regions associated general cognitive particular, reduced white matter volume compromised microstructural integrity areas-such as cingulate gyrus, inferior frontal banks superior temporal sulcus-showed significant associations scores These results suggest alterations may play critical role clinical manifestation MS. Understanding these insights could help differentiate from those affecting MS, which guide future therapeutic strategies.

Язык: Английский

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Global prevalence of fatigue in patients with multiple sclerosis: a systematic review and meta-analysis

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Окт. 2, 2024

Fatigue is one of the most common and burdensome symptoms for patients with multiple sclerosis (PwMS), considerably impacting their quality life employment. Numerous reports have described prevalence MS-related fatigue, but there no global consensus on this matter.

Язык: Английский

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Digital registry-based solution for screening and management of fatigue and cognitive problems in multiple sclerosis (Preprint)

Опубликована: Окт. 25, 2024

Digital patient registries are actively used in the monitoring of long-term diseases. The potential management symptoms is underutilized. present paper reports Finnish registry-based procedure to screen and manage cognitive fatigue multiple sclerosis (MS). data collected during first two years presented. Symbol Digit Modalities Test (SDMT), Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), Fatigue Scale for Motor Cognitive Functions (FSMC) were implemented into MS registry related cognition fatigue. For self-management purposes, feedback based on results MSNQ FSMC created. To assess patient-perceived disease severity, disability, quality life (QoL), Patient-Reported Expanded Disability Status (PREDSS), Visual Analogue Scales (VAS), Euro Quality Life – 5 Dimension (EQ-5D) registry. At end 2020, concerns together with self-assessment status, symptoms, QoL annually was introduced. By beginning 2023, 134 patients have been assessed SDMT. 329 filled out 172 at least once received corresponding reports. mean SDMT score 49.6, 35.3, total 63.0, sub-score motor 31.6 31.5, respectively. offers a digital platform systematic screening problems MS. Patient should be better recognized as e-Health solutions.

Язык: Английский

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Finnish Registry-Based Protocol for Screening and Management of Fatigue and Cognitive Problems in Multiple Sclerosis: Protocol Description and Preliminary Results (Preprint)

JMIR Human Factors, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Язык: Английский

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