High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis

JAMA, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Importance Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and associated with the of disease activity, but data on benefits supplementation are conflicting. Objective To evaluate efficacy high-dose cholecalciferol as monotherapy in reducing activity patients clinically isolated syndrome (CIS) typical MS. Design, Setting, Participants The D-Lay MS trial was parallel, double-blind, randomized placebo-controlled clinical 36 centers France. Patients were enrolled from July 2013 to December 2020 (final follow-up January 18, 2023). Untreated CIS aged 18 55 years duration less than 90 days, serum vitamin concentration 100 nmol/L, diagnostic magnetic resonance imaging (MRI) meeting 2010 criteria dissemination space or 2 more lesions presence oligoclonal bands recruited. Intervention 1:1 receive oral 000 IU (n = 163) placebo 153) every weeks 24 months. Main Outcomes Measures primary outcome measure defined occurrence relapse and/or MRI (new contrast-enhancing lesions) over months follow-up, also analyzed separate secondary outcomes. Results Of 316 participants (median [IQR] age, 34 [28-42] years; 70% women), analysis included 303 (95.9%) who took at least 1 dose study drug 288 (91.1%) ultimately completed 24-month trial. Disease observed 94 (60.3%) group 109 (74.1%) (hazard ratio [HR], 0.66 [95% CI, 0.50-0.87]; P .004), median time longer (432 vs 224 days; log-rank .003). All 3 outcomes reported significant differences favoring group: (89 [57.1%] 96 [65.3%]; HR, 0.71 0.53-0.95]; .02), new (72 [46.2%] 87 [59.2%]; 0.61 0.44-0.84]; .003), (29 [18.6%] 50 [34.0%]; 0.47 0.30-0.75]; .001). 10 showed no difference, including relapse, which occurred 28 (17.9%) 32 (21.8%) (HR, 0.69 0.42-1.16]; .16). similar subset 247 updated 2017 relapsing-remitting treatment initiation. Severe adverse events 17 13 group, none related cholecalciferol. Conclusions Relevance Oral significantly reduced early These results warrant further investigation, potential role pulse add-on therapy. Trial Registration ClinicalTrials.gov Identifier: NCT01817166

Язык: Английский

---

Factors associated with vitamin D levels in Mongolian patients with multiple sclerosis

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0317279 - e0317279

Опубликована: Янв. 24, 2025

Background Multiple sclerosis (MS) onset is caused by genetic and environmental factors. Vitamin D has been identified as contributing risk factor, with higher prevalence at latitudes further from the equator. Mongolia, 45°N, limited sunlight exposure, increasing population’s for vitamin deficiency. Objectives To compare levels between persons MS (pwMS) without to identify factors associated low D. Methods We investigated associations using data cases controls Mongolia. used linear mixed-effects regression fixed effects (case status, sociodemographics, predefined variables) participant-specific random intercepts. Results Of 62 participants (31 pwMS, 31 controls), pwMS had lower summer [median 23.00 ng/ml (interquartile range 11.30–31.50) vs. 25.00 (19.25–32.00)] winter [21.00 (10.60–27.60) 23.50 (15.55–28.60)], a smaller seasonal decline. deficiency was more prevalent in pwMS. None of these findings reached statistical significance. Winter season being breastfed child were significantly levels. Conclusion common among which could be influenced behavioural These may inform targeted recommendations maintain sufficient

Язык: Английский

---

From prevention to management: Exploring the impact of diet on multiple sclerosis

Translational Neuroscience, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 1, 2025

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system characterized by neuroinflammation and progressive neurodegeneration. Growing evidence suggests that dietary interventions may influence MS progression symptom management modulating inflammation, oxidative stress, gut microbiota composition. This narrative review examines effects Mediterranean, plant-based, ketogenic, Wahls, Swank, intermittent fasting, gluten-free diets, alongside key nutrients such as omega-3 fatty acids, vitamin D, polyphenols, antioxidants. Among these, Mediterranean plant-based diets have shown most consistent benefits, including reductions in fatigue, improved quality life, modulation inflammatory markers. The Wahls Swank show promise but are primarily supported studies from their respective research groups, raising concerns about long-term adherence nutritional adequacy. ketogenic diet fasting yielded mixed findings, with some suggesting benefits for fatigue neuroprotection, while others highlight potential metabolic risks. supplementation lack robust evidence, inconsistent findings across studies. Additionally, ultra-processed foods high saturated fats been associated increased inflammation greater severity. Despite promising limitations small sample sizes, short follow-up durations, study design inconsistencies prevent definitive conclusions. Future should prioritize large-scale, randomized controlled trials to establish efficacy, safety, sustainability management. Mechanistic standardized protocols also needed better understand role control.

Язык: Английский

---

The Relationship Between Autoimmune Disorders and Multiple Sclerosis: Clinical Insights and Therapeutic Approaches

Brain Sciences, Год журнала: 2025, Номер 15(6), С. 588 - 588

Опубликована: Май 30, 2025

Background: Multiple sclerosis (MS) and autoimmune diseases (AIDs) share immunological underpinnings, leading to frequent co-occurrence. This study investigated the prevalence of AIDs among Polish patients with MS (PwMSs) its potential effects on disease characteristics. The aims were compare clinical demographic characteristics between PwMSs without coexisting AIDs. Methods: A retrospective analysis was conducted data from 580 who treated at Department Neurology, University Clinical Center in Katowice, Poland, February 2018 August 2023. Variables analyzed included age, sex, type, duration, treatment, Expanded Disability Status Scale (EDSS) scores, thyroid-stimulating hormone (TSH), vitamin D3 serum concentrations. Results: AID identified 16.9% (n = 98). Compared AIDs, exhibited significantly higher mean age (44.61 ± 11.40 vs. 42.24 12.27 years; p 0.0151), longer duration (10.77 6.72 9.56 7.19 0.0102), EDSS scores (2.97 1.43 2.89 1.84; 0.0261). Among PwMSs, females (20.24%) compared males (8.13%; 0.0022), strongly associated relapsing-remitting subtype (p 0.0352). Autoimmune thyroid markedly most prevalent (hypothyroidism 7.24%). Conclusions: exhibit distinct characteristics, including older increased greater disability. Thyroid disorders are notably PwMSs. These findings underscore intricate interplay highlight necessity for further research into their long-term impact.

Язык: Английский

---

Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, Год журнала: 2024, Номер 23(2), С. 138 - 147

Опубликована: Апрель 3, 2024

Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease affecting the central nervous system. Immune cell subsets, notably T helper (Th) 17 and Th1, exert important roles in MS pathogenesis. Whereas, Treg cells modulate process. Calcitriol, active form of vitamin D, curcumin, bioactive compound derived from turmeric, play immunomodulatory effects relevant to disorders, including MS. The objective this study investigate calcitriol Curcumin on Peripheral blood mononuclear (PBMCs) individuals with

Язык: Английский

---

Vitamin D in Multiple Sclerosis: A Comprehensive Umbrella Review

Journal of Nutrition, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

---

Vitamin D verhindert nicht die Entstehung einer MS nach erstem klinischen Ereignis

InFo Neurologie + Psychiatrie, Год журнала: 2024, Номер 26(5), С. 12 - 13

Опубликована: Май 1, 2024

---