Antitumor Applications of Photothermal Agents and Photothermal Synergistic Therapies

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(14), С. 7909 - 7909

Опубликована: Июль 18, 2022

As a new tumor treatment strategy, photothermal therapy (PTT) has the advantages of accuracy, ease administration, high efficiency and low side effects. Photothermal transduction agents (PTAs) are key factor which play an important role in PTT. The mechanism PTT is discussed detail. conversion (PCE) can be improved by increasing light absorption reducing scattering agents. Additionally, non-radiative relaxation path attenuation also promote energy to obtain higher value terms PCE. structure characteristics various kinds PTAs (metal materials, carbon-based nanomaterials, two-dimensional organic materials) were compared analyzed. This paper reviews antitumor applications synergistic therapies, including combined with immunotherapy, chemotherapy, photodynamic therapy. review proposes that these development therapies have great potential application treatment.

Язык: Английский

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Current and promising applications of Hf(iv)-based MOFs in clinical cancer therapy

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(25), С. 5693 - 5714

Опубликована: Янв. 1, 2023

Cancer is one of the greatest challenges in medical science today as it poses a serious threat to human life. In view this, myriad therapeutic strategies are being developed for treatment cancer. Despite use various approaches, they still insufficient The rapid advancement nanotechnology currently offers exciting possibilities creation novel cancer therapy approaches. Metal organic frameworks (MOFs) emerging multifunctional nanomaterials that find prospective applications biomedical field owing their porosity, large specific surface area, and diversified structures. Amongst varied categories MOFs, Hf(IV)-based MOFs have been since 2012 finding new hence this class gaining immense attention amongst material biomaterial chemists. Most importantly, Hf(IV)-MOFs comprising high Z-Hf metal content may be capable offering options therapy, nonlinear optics, fluorescent sensors, photoresponsive devices. review, progress using radiotherapy, chemotherapy, immunotherapy, phototherapeutic techniques, or combination two more these techniques explored. This review also provides insight regarding current limitations future prospects therapy.

Язык: Английский

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Biomaterials for Drug Delivery and Human Applications

Materials, Год журнала: 2024, Номер 17(2), С. 456 - 456

Опубликована: Янв. 18, 2024

Biomaterials embody a groundbreaking paradigm shift in the field of drug delivery and human applications. Their versatility adaptability have not only enriched therapeutic outcomes but also significantly reduced burden adverse effects. This work serves as comprehensive overview biomaterials, with particular emphasis on their pivotal role delivery, classifying them terms biobased, biodegradable, biocompatible nature, highlighting characteristics advantages. The examination delves into extensive array applications for biomaterials encompassing diverse medical fields such cancer therapy, cardiovascular diseases, neurological disorders, vaccination. explores actual challenges within this domain, including potential toxicity complexity manufacturing processes. These emphasize necessity thorough research continuous development regulatory frameworks. second aim review is to navigate through compelling terrain recent advances prospects envisioning healthcare landscape where they empower precise, targeted, personalized delivery. transform staggering, promise treatments tailored individual patient needs, offering hope improved efficacy, fewer side effects, brighter future practice.

Язык: Английский

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Nanomaterials-assisted photothermal therapy for breast cancer: State-of-the-art advances and future perspectives

Photodiagnosis and Photodynamic Therapy, Год журнала: 2024, Номер 45, С. 103959 - 103959

Опубликована: Янв. 21, 2024

Breast cancer (BC) remains an enigmatic fatal modality ubiquitously prevalent in different parts of the world. Contemporary medicines face severe challenges remediating and healing breast cancer. Due to its spatial specificity nominal invasive therapeutic regime, photothermal therapy (PTT) has attracted much scientific attention down lane. PTT utilizes a near-infrared (NIR) light source irradiate tumor target intravenously or non-invasively, which is converted into heat energy over optical fibre. Dynamic progress nanomaterial synthesis was achieved with specialized visual, physicochemical, biological, pharmacological features make up for inadequacies expand horizon PTT. Numerous nanomaterials have substantial NIR absorption can function as efficient transducers. It achievable limit wavelength range absorbance peak specific by manipulating their synthesis, enhancing precision quality Along same lines, various are conjugated wide surface-modifying chemicals, including polymers antibodies, may modify persistence diminish toxicity concerns. In this article, we tend put forth insights fundamental conceptualizations on pre-existing advances upon conjugation biocompatible working synergy combat cancer, encompassing several strategies like immunotherapy, chemotherapy, photodynamic therapy, radiotherapy coupled Additionally, role mechanisms nanoparticles, well possible alternatives PTT, summarized distinctive integral aspect article.

Язык: Английский

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Injectable nano-composite hydrogels based on hyaluronic acid-chitosan derivatives for simultaneous photothermal-chemo therapy of cancer with anti-inflammatory capacity

Carbohydrate Polymers, Год журнала: 2023, Номер 310, С. 120721 - 120721

Опубликована: Фев. 20, 2023

Язык: Английский

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