ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(7), С. 4193 - 4230
Опубликована: Июль 3, 2024
Polysaccharides
(PSAs)
are
carbohydrate-based
macromolecules
widely
used
in
the
biomedical
field,
either
their
pure
form
or
blends/nanocomposites
with
other
materials.
The
relationship
between
structure,
properties,
and
functions
has
inspired
scientists
to
design
multifunctional
PSAs
for
various
applications
by
incorporating
unique
molecular
structures
targeted
bulk
properties.
Multiple
strategies,
such
as
conjugation,
grafting,
cross-linking,
functionalization,
have
been
explored
control
mechanical
electrical
conductivity,
hydrophilicity,
degradability,
rheological
features,
stimuli-responsiveness.
For
instance,
custom-made
known
worldwide
tissue
engineering,
drug/gene
delivery,
regenerative
medicine.
Furthermore,
remarkable
advancements
supramolecular
engineering
chemistry
paved
way
mission-oriented
biomaterial
synthesis
fabrication
of
customized
biomaterials.
These
materials
can
synergistically
combine
benefits
biology
tackle
important
questions.
Herein,
we
categorize
summarize
based
on
methods,
explore
main
strategies
customize
chemical
structures.
We
then
highlight
properties
using
practical
examples.
Lastly,
thoroughly
describe
tailor-made
PSAs,
along
current
existing
challenges
potential
future
directions.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(30), С. 34455 - 34469
Опубликована: Июль 20, 2022
Engineered
wound
dressing
materials
with
excellent
injectability,
self-healing
ability,
tissue-adhesiveness,
especially
the
ones
possessing
potential
therapeutic
effects
have
great
practical
significance
in
healthcare.
Herein,
an
injectable
quaternary
ammonium
chitosan
(QCS)/tannic
acid
(TA)
hydrogel
based
on
QCS
and
TA
was
designed
fabricated
by
facile
mixing
of
two
ingredients
under
physiological
conditions.
In
this
system,
hydrogels
were
mainly
cross-linked
dynamic
ionic
bonds
hydrogen
between
TA,
which
endows
injectable,
self-healing,
adhesive
properties.
Benefitting
from
inherent
antioxidative,
antibacterial,
hemostatic
abilities
QCS,
showed
superior
reactive
oxygen
species
scavenging
activity,
broad-spectrum
antibacterial
as
well
rapid
capability.
Moreover,
QCS/TA2.5
(containing
2.5%
TA)
exhibited
biocompatibility.
The
vivo
experiments
also
that
not
only
rapidly
stopped
bleeding
arterial
deep
incompressible
wounds
mouse
tail
amputation,
femoral
artery
hemorrhage,
liver
incision
models
but
significantly
accelerated
healing
a
full-thickness
skin
model.
For
potentials
listed
above,
multifunctional
offers
promising
network
material
for
both
hemostasis
repair.
Environmental Research,
Год журнала:
2023,
Номер
231, С. 116133 - 116133
Опубликована: Май 19, 2023
Membranes
are
ubiquitous
tools
for
modern
water
treatment
technology
that
critically
eliminate
hazardous
materials
such
as
organic,
inorganic,
heavy
metals,
and
biomedical
pollutants.
Nowadays,
nano-membranes
of
particular
interest
myriad
applications
treatment,
desalination,
ion
exchange,
concentration
control,
several
kinds
applications.
However,
this
state-of-the-art
suffers
from
some
drawbacks,
e.g.,
toxicity
fouling
contaminants,
which
makes
the
synthesis
green
sustainable
membranes
indeed
safety-threatening.
Typically,
sustainability,
non-toxicity,
performance
optimization,
commercialization
concerns
centered
on
manufacturing
synthesized
membranes.
Thus,
critical
issues
related
to
toxicity,
biosafety,
mechanistic
aspects
green-synthesized
have
be
systematically
comprehensively
reviewed
discussed.
Herein
we
evaluate
various
in
terms
their
synthesis,
characterization,
recycling,
aspects.
Nanomaterials
intended
nano-membrane
development
classified
view
chemistry/synthesis,
advantages,
limitations.
Indeed,
attaining
prominent
adsorption
capacity
selectivity
requires
multi-objective
optimization
a
number
parameters.
In
addition,
efficacy
removal
analyzed
theoretically
experimentally
provide
researchers
manufacturers
with
comprehensive
image
efficiency
under
real
environmental
conditions.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 657 - 657
Опубликована: Фев. 15, 2023
The
topical
route
is
the
most
appropriate
for
targeted
delivery
of
drugs
to
skin
tissues
treatment
local
diseases;
however,
stratum
corneum
(SC),
foremost
layer
skin,
acts
as
a
major
barrier.
Numerous
passive
and
active
drug
techniques
have
been
exploited
overcome
this
barrier;
these
modalities
are
associated
with
several
detrimental
effects
which
restrict
their
clinical
applicability.
Alternatively,
nanotechnology-aided
interventions
extensively
investigated
administration
wide
range
therapeutics.
In
review,
we
mainly
focused
on
biopharmaceutical
significance
polymeric
nanoparticles
(PNPs)
(made
from
natural
polymers)
various
diseases
such
psoriasis,
atopic
dermatitis
(AD),
infection,
cancer,
acute-to-chronic
wounds,
acne.
encapsulation
drug(s)
into
inner
core
or
adsorption
onto
shell
PNPs
has
shown
marked
improvement
in
physicochemical
properties,
avoiding
premature
degradation
controlling
release
kinetics,
permeation
through
SC,
retention
layers.
Furthermore,
functionalization
PEGylation,
conjugation
targeting
ligand,
pH/thermo-responsiveness
further
success
optimizing
therapeutic
efficacy
diseases.
Despite
enormous
progress
development
PNPs,
translation
still
lacking,
could
be
potential
future
perspective
researchers
working
field.
