A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules
Chemical Communications,
Год журнала:
2022,
Номер
59(7), С. 807 - 835
Опубликована: Ноя. 11, 2022
Transferring
the
layer-by-layer
(LbL)
coating
approach
from
planar
surfaces
to
spherical
templates
and
subsequently
dissolving
these
leads
fabrication
of
polyelectrolyte
multilayer
capsules.
The
versatility
coatings
capsules
their
flexibility
upon
bringing
in
virtually
any
material
into
has
quickly
drawn
substantial
attention.
Here,
we
provide
an
overview
main
developments
this
field,
highlighting
trends
last
decade.
In
beginning,
various
methods
encapsulation
release
are
discussed
followed
by
a
broad
range
applications,
which
were
developed
explored.
We
also
outline
current
trends,
where
applications
is
continuing
grow,
including
addition
whole
new
different
application
areas.
Язык: Английский
Polyelectrolyte Multilayered Capsules as Biomedical Tools
Polymers,
Год журнала:
2022,
Номер
14(3), С. 479 - 479
Опубликована: Янв. 25, 2022
Polyelectrolyte
multilayered
capsules
(PEMUCs)
obtained
using
the
Layer-by-Layer
(LbL)
method
have
become
powerful
tools
for
different
biomedical
applications,
which
include
drug
delivery,
theranosis
or
biosensing.
However,
exploitation
of
PEMUCs
in
field
requires
a
deep
understanding
most
fundamental
bases
underlying
their
assembly
processes,
and
control
properties
to
fabricate
novel
materials
with
optimized
ability
specific
targeting
therapeutic
capacity.
This
review
presents
an
updated
perspective
on
multiple
avenues
opened
application
field,
aiming
highlight
some
important
advantages
offered
by
LbL
fabrication
platforms
use
detection
treatment
diseases.
Язык: Английский
Exploiting the layer-by-layer nanoarchitectonics for the fabrication of polymer capsules: A toolbox to provide multifunctional properties to target complex pathologies
Advances in Colloid and Interface Science,
Год журнала:
2022,
Номер
304, С. 102680 - 102680
Опубликована: Апрель 17, 2022
Polymer
capsules
fabricated
via
the
layer-by-layer
(LbL)
approach
have
attracted
a
great
deal
of
attention
for
biomedical
applications
thanks
to
their
tunable
architecture.
Compared
alternative
methods,
in
which
precise
control
over
final
properties
systems
is
usually
limited,
intrinsic
versatility
LbL
allows
functionalization
all
constituents
polymeric
following
relatively
simple
protocols.
In
fact,
can
be
adjusted
from
inner
cavity
outer
layer
through
shell,
resulting
therapeutic,
diagnostic,
or
theranostic
(i.e.,
combination
therapeutic
and
diagnostic)
agents
that
adapted
particular
characteristics
patient
face
challenges
encountered
complex
pathologies.
The
industry
demands
novel
biomaterials
capable
targeting
several
mechanisms
and/or
cellular
pathways
simultaneously
while
being
tracked
by
minimally
invasive
techniques,
thus
highlighting
need
shift
monofunctional
multifunctional
polymer
capsules.
present
review,
those
strategies
permit
advanced
are
accordingly
introduced.
Each
capsule
cavity,
multilayer
membrane
layer)
thoroughly
analyzed
overview
toward
fabrication
presented.
Special
emphasis
given
potential
these
capsules,
including
examples
performed
vitro
vivo
validation
studies.
Finally,
process
future
perspective
safe
translation
into
clinic
summarized.
Язык: Английский
Enhanced wound healing in diabetic mice by hyaluronan/chitosan multilayer-coated PLLA nanofibrous mats with sustained release of insulin
Applied Surface Science,
Год журнала:
2021,
Номер
576, С. 151825 - 151825
Опубликована: Ноя. 9, 2021
Язык: Английский
A design approach for layer-by-layer surface-mediated siRNA delivery
Acta Biomaterialia,
Год журнала:
2021,
Номер
135, С. 331 - 341
Опубликована: Сен. 1, 2021
Язык: Английский
Biomimetic materials based on hydroxyapatite patterns for studying extracellular cell communication
Materials & Design,
Год журнала:
2024,
Номер
238, С. 112718 - 112718
Опубликована: Фев. 1, 2024
The
study
of
cellular
ion
channels
forms
a
basic
understanding
healthy
organ
functioning
and
the
body
as
whole;
however,
native
role
signal
transmission
through
between
cells
remains
unclear.
success
investigation
depends
on
methods
materials
used.
Therefore,
it
is
necessary
to
develop
new
approach
system
for
studying
detecting
cell–cell
communication.
In
this
work,
we
suggest
hydroxyapatite
patterns
demonstrating
piezoresponse
in
conjunction
with
fiber-based
biosensors
detection
electrical
signaling
communities.
Our
does
not
disrupt
integrity
cell
membrane.
are
located
self-assembled
forming
tissue
communicating
via
spatially
propagating
waves
calcium,
sodium,
potassium
ions.
These
result
from
positive
feedback
caused
by
activation
Ca2+
channels.
ion-selective
microelectrodes
fixed
above
used
detect
potassium,
calcium
currents
extracellular
space.
We
use
norepinephrine
activate
intracellular
release
communities
different
patterns.
This
could
be
perspective
an
efficient
platform
lab-on-a-chip
well
fundamental
communication
during
regeneration.
Язык: Английский
On-chip fabrication of calcium carbonate nanoparticles loaded with various compounds using microfluidic approach
Konstantin V. Arabuli,
Elena Kopoleva,
Anas Akenoun
и другие.
Biomaterials Advances,
Год журнала:
2024,
Номер
161, С. 213904 - 213904
Опубликована: Май 23, 2024
Язык: Английский
Control Morphology and Biological Properties of HKUST-1 MOFs Using an Ultrasound-Assisted Approach
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(9), С. 6201 - 6212
Опубликована: Сен. 4, 2024
The
synthesis
of
bioinspired
metal-organic
frameworks
(MOFs)
performed
in
mild
conditions
with
a
high
quality
is
greatly
demanded.
Moreover,
the
influence
morphology
and
structure
bio-MOFs
on
cell
interaction
toxicity
important
to
determine.
In
this
work,
we
developed
an
ultrasound
(US)-assisted
HKUST-1
MOFs
under
investigated
parameters
morphology,
structure,
biological
properties
MOFs.
It
was
found
that
US
power,
reaction
time,
temperature,
type
solvent
composition
would
affect
size,
yield
obtained
crystals.
Employing
optimal
synthetic
conditions,
five
types
were
prepared,
achieving
highest
yields
(67.8-96.2%)
different
morphologies
(octahedral,
dodecahedral,
icosahedral).
relationship
between
morphological
features
evaluated
discussed.
cellular
association
cytotoxicity
MOF@US
MOF@US-PARG
studied
various
cultures,
Язык: Английский
Biodegradable particles for protein delivery: Estimation of the release kinetics inside cells
Biomaterials Advances,
Год журнала:
2022,
Номер
139, С. 212966 - 212966
Опубликована: Июнь 1, 2022
A
methodology
to
quantify
the
efficiency
of
protein
loading
and
in-vitro
delivery
for
biodegradable
capsules
with
different
architectures
based
on
polyelectrolytes
(dextran
sulfate,
poly-L-arginine
polyethylenimine)
SiO2
was
developed.
The
were
loaded
model
proteins
such
as
ovalbumin
green
fluorescent
(GFP),
release
profile
inside
cells
(either
macrophages
or
HeLa
cells)
after
endocytosis
analysed.
Both,
kinetics
evaluated
by
analysing
confocal
laser
scanning
microscopy
images
using
MatLab
CellProfiler
software.
Our
results
indicate
that
silica
showed
most
efficient
cargo
molecules
within
48
h,
compared
their
polymeric
counterparts.
This
developed
method
analysis
intracellular
from
carrier
structures
could
be
used
in
future
a
better
control
drug
profiles.
Язык: Английский
Heat‐triggered thermo‐irreversible gelation of curdlan to control crystallisation and in vitro release of nobiletin
International Journal of Food Science & Technology,
Год журнала:
2022,
Номер
58(1), С. 74 - 82
Опубликована: Окт. 25, 2022
Summary
Many
kinds
of
flavonoids
with
poor
water
solubility
and
high
crystallisation
properties
tend
to
crystallise
in
the
system,
which
negatively
affects
their
processing,
storage
bioavailability.
Hence,
controlling
crystal
growth
is
an
effective
pathway
achieve
stabilisation.
Inspired
by
heat‐triggered
gelation
curdlan
(Cur),
nobiletin
(NOB)
supersaturated
solution
was
mixed
Cur
gel
under
heating
treatment,
following
formation
might
control
NOB
process
situ
.
The
results
showed
that
different
proportions
could
change
size
crystals,
a
concentration
higher
than
4%
better
NOB.
effect
on
texture
rheological
after
addition
investigated
detail.
Finally,
vitro
release
experiments
played
great
role
sustained
release,
greatly
improving
efficiency
compared
pure
samples.
Taken
together,
this
study
proposes
simple
stabilisation
method
initially
attempts
overcome
some
bottlenecks
processing
hydrophobic
substances.
Язык: Английский