Preparation of La2(WO4)3/CuWO4 composite nanomaterials with enhanced sonodynamic anti-glioma activity DOI Creative Commons
Fang-Yu Liu, Xin Wang,

Ye-Fu Liu

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 20, 2025

Introduction Sonodynamic therapy (SDT) is an innovative way to treat tumors by activating sonosensitizers via ultrasound (US). The development of with high sonodynamic activity the key promote clinical application SDT. Methods In this study, a novel sonosensitizer, La 2 (WO 4 ) 3 /CuWO composite LC-10, was prepared two-step hydrothermal method and characterized. addition, antitumor LC-10 investigated using u251 glioma cells as model. Results Discussion results showed that compared CuWO , had better activity, good biosafety at concentrations below 50 μg/mL. After formed composite, recombination electron-hole ( e − – h + pairs were effectively inhibited, more strongly oxidizing ROS produced, inducing apoptosis cells. which, singlet oxygen 1 O hydroxyl radical (·OH), especially production ⋅OH, played important role in mediated SDT process. study would offer foundation for design base nano-sonosensitizers its further antitumor. it also provided new strategy excellent activity.

Язык: Английский

Preparation of La2(WO4)3/CuWO4 composite nanomaterials with enhanced sonodynamic anti-glioma activity DOI Creative Commons
Fang-Yu Liu, Xin Wang,

Ye-Fu Liu

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 20, 2025

Introduction Sonodynamic therapy (SDT) is an innovative way to treat tumors by activating sonosensitizers via ultrasound (US). The development of with high sonodynamic activity the key promote clinical application SDT. Methods In this study, a novel sonosensitizer, La 2 (WO 4 ) 3 /CuWO composite LC-10, was prepared two-step hydrothermal method and characterized. addition, antitumor LC-10 investigated using u251 glioma cells as model. Results Discussion results showed that compared CuWO , had better activity, good biosafety at concentrations below 50 μg/mL. After formed composite, recombination electron-hole ( e − – h + pairs were effectively inhibited, more strongly oxidizing ROS produced, inducing apoptosis cells. which, singlet oxygen 1 O hydroxyl radical (·OH), especially production ⋅OH, played important role in mediated SDT process. study would offer foundation for design base nano-sonosensitizers its further antitumor. it also provided new strategy excellent activity.

Язык: Английский

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