Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Abstract
Uncontrolled
traumatic
hemorrhage
is
a
leading
cause
of
preventable
death.
As
two
main
forms
hemostatic
materials,
however,
both
sponges
and
hydrogel
adhesives
usually
fail
to
control
massive
due
their
respective
shortcomings.
Hemostatic
sponge
shows
weak
tissue
adhesion,
while
the
gelation
process
makes
it
difficult
seal
high‐pressure
bleeding
wounds.
There
an
urgent
need
develop
next‐generation
hemostats
combining
advantages
adhesives.
Herein,
general
methodology
prepare
novel
Fe
3+
‐laden
porous
material
(Fe
@GCS)
for
rapid
hemostasis
severe
hemorrhages
proposed,
which
fabricated
by
loading
ferric
chloride
with
ethanol
into
catechol‐modified
carboxylated
gelatin
(GCS).
Notably,
@GCS
can
undergo
water‐triggered
transformation
robust‐adhesive
hydrogels.
The
sealing
strength
on
wet
tissues
reaches
astonishing
≈600
mm
Hg.
Rapid
water
uptake
around
wound
not
only
concentrates
blood
components
but
also
excludes
interfacial
water,
facilitating
clotting
in
situ
formed
sticky
hydrogel.
efficiently
stop
hemorrhaging
from
injuries
arteries
hearts
rats
pigs,
respectively,
via
simple
short‐time
pressing.
Furthermore,
promotes
repair
healing.
Journal of Research Updates in Polymer Science,
Год журнала:
2024,
Номер
13, С. 34 - 44
Опубликована: Авг. 5, 2024
The
work
is
devoted
to
the
development
of
safe
and
biocompatible
multicomponent
gelatin-alginate
hydrogels
modified
with
humic
acids
(HA)
impregnated
antifibrinolytic
agent
aminocaproic
acid
(АА).These
are
designed
be
effective
hemostatic
materials
anti-inflammatory
properties
ability
deliver
in
less
than
30
seconds
deep
hidden
areas
hemorrhages.
Studies
crystal
structure
by
X-ray
diffraction
analysis
non-covalent
interactions
molecules
Fourier
transform
infrared
spectroscopy
developed
bactericidal
made
it
possible
identify
optimal
concentrations
HA
from
2.5
wt.%.
up
5
At
such
HA,
have
a
semicrystalline
structure.
Due
bonds
between
polymer
chains,
they
thermo-responsive
gel-sol
transition
temperature
about
37
°C.
Impregnation
these
led
an
almost
threefold
increase
their
swelling,
which
facilitated
dissolution
AA
its
subsequent
delivery
wound.
Experiments
simulating
transmembrane
transport
confirmed
rapidly
494±
3
mg
ml
hydrogel
Biomacromolecules,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Hemorrhage
is
a
significant
medical
problem
that
has
been
an
active
area
of
research
over
the
past
few
decades.
The
human
body
complex
response
to
bleeding
leads
blood
clot
formation
and
hemostasis.
Many
biomaterials
based
on
various
biomacromolecules
have
developed
either
accelerate
or
improve
body's
natural
bleeding.
This
review
examines
mechanisms
hemostasis,
types
bleeding,
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(33), С. 43244 - 43256
Опубликована: Авг. 13, 2024
The
development
of
efficient
hemostatic
materials
is
crucial
for
achieving
rapid
hemorrhage
control
and
effective
wound
healing.
Inorganic
polyphosphate
(polyP)
recognized
as
an
modulator
the
blood
coagulation
process.
However,
specific
effect
polyP
chain
length
on
not
yet
fully
understood.
Furthermore,
calcium
ions
(Ca
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101361 - 101361
Опубликована: Ноя. 22, 2024
Promoting
wound
nerve
regeneration
and
synchronously
initiating
angiogenesis
are
critical
factors
in
the
healing
process
of
diabetic
wounds.
However,
existing
research
on
wounds
mainly
focuses
angiogenesis,
bacterial
infection
reactive
oxygen
species,
often
failing
to
coordinate
neurogenesis
angiogenesis.
To
symbiosis
nerves
blood
vessels
wounds,
we
successfully
designed
a
multifunctional
chitosan
(CS)-based
sponges
by
regulating
structure
CS
specifically
for
healing.
This
sponge,
which
facilitates
effective
exudate
transfer
modulates
microenvironment,
was
constructed
using
hydroxybutyl
grafted
with
thioctic
acid
(TA),
named
as
HCT
sponge.
When
applied
humid
environment,
hydrophobic
side
chains
sponge
interact
self-assembled
domains,
forming
gel-sponge
composite.
Experimental
results
showed
that
adhesion
strength
wet
porcine
skin
70.3
kPa.
Additionally,
exhibited
favorable
degradability,
cytocompatibility
antioxidant
properties.
As
it
is
shown
experiments
vitro,
can
not
only
promote
cell
proliferation,
migration,
vessel
formation,
but
also
M2
macrophage
polarization.
Moreover,
rat
liver
femoral
artery
injury
model
validated
effectively
treat
heavy
bleeding
from
efficacy
through
quickly
sealing
formation
multiple
hemostatic
dams.
In
vivo
studies
indicated
significantly
accelerated
compared
recombinant
bovine
basic
fibroblast
growth
factor
gel,
achieving
better
recovery
after
15
days.
Pathological
show
novel
holds
considerable
promise
treating
wound,
allowing
regenerative
at
site,
provides
significant
potential
further
improving
clinical
applications.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Abstract
Uncontrolled
traumatic
hemorrhage
is
a
leading
cause
of
preventable
death.
As
two
main
forms
hemostatic
materials,
however,
both
sponges
and
hydrogel
adhesives
usually
fail
to
control
massive
due
their
respective
shortcomings.
Hemostatic
sponge
shows
weak
tissue
adhesion,
while
the
gelation
process
makes
it
difficult
seal
high‐pressure
bleeding
wounds.
There
an
urgent
need
develop
next‐generation
hemostats
combining
advantages
adhesives.
Herein,
general
methodology
prepare
novel
Fe
3+
‐laden
porous
material
(Fe
@GCS)
for
rapid
hemostasis
severe
hemorrhages
proposed,
which
fabricated
by
loading
ferric
chloride
with
ethanol
into
catechol‐modified
carboxylated
gelatin
(GCS).
Notably,
@GCS
can
undergo
water‐triggered
transformation
robust‐adhesive
hydrogels.
The
sealing
strength
on
wet
tissues
reaches
astonishing
≈600
mm
Hg.
Rapid
water
uptake
around
wound
not
only
concentrates
blood
components
but
also
excludes
interfacial
water,
facilitating
clotting
in
situ
formed
sticky
hydrogel.
efficiently
stop
hemorrhaging
from
injuries
arteries
hearts
rats
pigs,
respectively,
via
simple
short‐time
pressing.
Furthermore,
promotes
repair
healing.
