Redox Biology, Год журнала: 2024, Номер 79, С. 103451 - 103451
Опубликована: Ноя. 30, 2024
Язык: Английский
Cureus, Год журнала: 2024, Номер unknown
Опубликована: Фев. 22, 2024
Background: Enterococcus faecalis biofilm formation within root canals poses a challenging problem in endodontics, often leading to treatment failure. To combat this issue, nanotechnology offers promising avenue for enhancing antimicrobial efficacy. This study explores the potential synergistic effects of combining nanoscale silica particles with conventional antibiotics, including doxycycline, metronidazole, and ciprofloxacin, against E. biofilms. The unique characteristics nanoparticles, such as their increased reactivity ability be functionalized other compounds, make them ideal candidates augmenting antibiotic research investigates properties these silica-based combinations eliminate or inhibit biofilms more effectively than treatments. Methodology: methods involved preparation nanostructured combination Flagyl, ciprofloxacin at subinhibitory concentrations. These were then tested using agar well diffusion technique. Results: Preliminary results suggested that interactions between nanoparticles antibiotics can significantly enhance combined exhibited superior inhibitory on compared alone (P < 0.05). Conclusions: sheds light address challenges posed by endodontics. Understanding mechanisms synergy pave way development effective targeted strategies canal disinfection, ultimately improving success rates endodontic
Язык: Английский
Процитировано
2
Deleted Journal, Год журнала: 2024, Номер 6(3)
Опубликована: Март 11, 2024
Abstract Background Dental adhesives with immobilized antibacterial agents are formulated to combat bacterial invasion along the tooth-restoration interface. This study aims evaluate effect of synthesized quaternary ammonium compound (QAC) incorporated into commercial dental adhesive. Methods QAC was from 2-(Dimethylamino) ethyl methacrylate and 1-Bromobutane characterized using CHN (Carbon, Hydrogen, Nitrogen), FTIR (Fourier transform infrared) H + NMR (Proton nuclear magnetic resonance) analyses. The assessed for its cytotoxicity activity against S. mutans disc diffusion method, minimum inhibitory concentration (MIC) bactericidal (MBC), time-kill kinetics test, TEM imaging. added primer a commercially available adhesive (OptiBond XTR) at two concentrations; 20 40 mg mL −1 representing MIC MBC, respectively. properties experimental adhesives, Clearfil SE Protect containing 12-methacryloyloxydodecylpyridinium bromide (MDPB), vehicle were compared test. Statistical analysis by ANOVA followed tukey post-hoc test ( P < 0.05). Results Disc tests showed potent action QAC, both in unpolymerized cured forms. MBC There no statistically significant difference between more than 99% reduction count, while OptiBond XTR killing up 10 h. Conclusions imparted properties, thus providing an affordable system local market.
Язык: Английский
Процитировано
2
International Immunopharmacology, Год журнала: 2024, Номер 138, С. 112595 - 112595
Опубликована: Июнь 30, 2024
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2024, Номер 11(40)
Опубликована: Авг. 29, 2024
Abstract The demineralization of dental hard tissue imposes considerable health and economic burdens worldwide, but an optimal method that can repair both the chemical composition complex structures has not been developed. continuous development nanotechnology created new opportunities for regeneration tissue. Increasingly studies have reported nanomaterials (NMs) induce regulate biomimetic mineralization tissue, few examined how they are involved in different stages, let alone relevant mechanisms action. Besides their nanoscale dimensions excellent designability, NMs play a corresponding role function raw materials mineralization, mineralized microenvironment, guidance, products. This review comprehensively summarizes advantages examines specific mechanisms. Design strategies to promote summarized according application purpose oral cavity, limitations directions remineralization proposed. provide theoretical basis understand interaction between thereby optimizing design strategy, rational development, clinical field remineralization.
Язык: Английский
Процитировано
2
Redox Biology, Год журнала: 2024, Номер 79, С. 103451 - 103451
Опубликована: Ноя. 30, 2024
Язык: Английский
Процитировано
2