Nanomaterials,
Год журнала:
2023,
Номер
14(1), С. 55 - 55
Опубликована: Дек. 24, 2023
Currently,
increasing
the
efficiency
of
glioblastoma
treatment
is
still
an
unsolved
problem.
In
this
study,
a
combination
promising
approaches
was
proposed:
(i)
application
nanotechnology
approach
to
create
new
terpene-modified
lipid
system
(7%
w/w),
using
soybean
L-α-phosphatidylcholine,
N-carbonyl-methoxypolyethylene
glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine
for
delivery
chemotherapy
drug,
temozolomide
(TMZ,
1
mg/mL);
(ii)
use
TMZ
associated
with
natural
compounds—terpenes
(1%
w/w)
abietic
acid
and
Abies
sibirica
Ledeb.
resin
(A.
sibirica).
Different
concentrations
combinations
terpene–lipid
systems
were
employed
treat
human
cancer
cell
lines
T
98G
(glioblastoma),
M-Hela
(carcinoma
cervix)
liver
(Chang
liver).
The
appeared
be
unilamellar
spherical
shape
under
transmission
electron
microscopy
(TEM).
creation
TMZ-loaded
nanosystem
about
100
nm
in
diameter
negative
surface
charge
found
by
dynamic
light
scattering.
74%
encapsulation
allowed
release
time
prolonged.
modification
terpenes
nanoparticles
improved
four
times
cytotoxicity
against
cells
decreased
normal
cells.
Terpene-modified
are
potential
interest
as
therapy.
Pharmaceutics,
Год журнала:
2023,
Номер
16(1), С. 58 - 58
Опубликована: Дек. 29, 2023
Alzheimer's
disease,
a
progressive
neurodegenerative
condition,
is
characterized
by
gradual
decline
in
cognitive
functions.
Current
treatment
approaches
primarily
involve
the
administration
of
medications
through
oral,
parenteral,
and
transdermal
routes,
aiming
to
improve
function
alleviate
symptoms.
However,
these
treatments
face
limitations,
such
as
low
bioavailability
inadequate
permeation.
Alternative
invasive
methods,
while
explored,
often
entail
discomfort
require
specialized
assistance.
Therefore,
development
non-invasive
efficient
delivery
system
crucial.
Intranasal
has
emerged
potential
solution,
although
it
constrained
unique
conditions
nasal
cavity.
An
innovative
approach
involves
use
nano-carriers
based
on
nanotechnology
for
intranasal
delivery.
This
strategy
overcome
current
limitations
providing
enhanced
bioavailability,
improved
permeation,
effective
traversal
blood-brain
barrier,
extended
retention
within
body,
precise
targeting
brain.
The
comprehensive
review
focuses
advancements
designing
various
types
nano-carriers,
including
polymeric
nanoparticles,
metal
lipid
liposomes,
nanoemulsions,
Quantum
dots,
dendrimers.
These
are
specifically
tailored
therapeutic
agents
aimed
at
combatting
disease.
In
summary,
utilization
systems
show
significant
surmounting
constraints
disease
strategies.
Nevertheless,
essential
acknowledge
regulatory
well
toxicity
concerns
associated
with
this
route;
meticulous
consideration
required
when
engineering
carrier.
underscores
revolutionize
management
highlights
importance
addressing
considerations
safe
implementations.
Embracing
could
lead
substantial
field
treatment.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 14256 - 14256
Опубликована: Сен. 19, 2023
The
most
prevalent
and
aggressive
type
of
brain
cancer,
namely,
glioblastoma
(GBM),
is
characterized
by
intra-
inter-tumor
heterogeneity
strong
spreading
capacity,
which
makes
treatment
ineffective.
A
true
therapeutic
answer
still
in
its
infancy
despite
various
studies
that
have
made
significant
progress
toward
understanding
the
mechanisms
behind
GBM
recurrence
resistance.
primary
causes
are
attributed
to
diffusive
nature;
therefore,
monitoring
tumor’s
may
offer
a
set
targets
could
improve
clinical
management
prevent
tumor
relapse.
Additionally,
blood–brain
barrier
(BBB)-related
poor
drug
delivery
prevents
effective
concentrations
within
discussed.
With
emphasis
on
signaling
heterogeneity,
infiltration,
computational
modeling
GBM,
this
review
covers
typical
difficulties
factors
contributing
resistance
development
discusses
potential
approaches.
Biomimetic
nanoparticles
(BioM
NPs)
feature
functionalization
that
imitates
the
biological
surroundings,
endowing
them
with
structure
and
functioning.
BioM
NPs
could
be
covered
biologically
sourced
materials
contain
synthetic
antigen-presenting
cells
structures.
Whenever
used
in
cancer
diagnostics,
outperform
standard
medications
comparable
non-BioM
NPs,
particularly
regarding
circulation
time,
tissue
penetration,
delivery,
toxicity.
The
particles
achieved
extraordinary
results
by
using
cell
material
for
which
avoids
difficult
bottom-up
approaches
aim
to
emulate
such
intricate
diverse
components.
One
area
of
this
rapidly
developing
research
has
gotten
a
lot
interest
is
use
treatment
different
cancers.
However,
best
our
knowledge,
no
published
study
primarily
analysed
current
improvements
therapy,
taking
into
account
most
common
tumours
processes.
As
result,
purpose
present
review
address
gap
first.
discussion
will
next
go
numerous
recent
advances
therapy.
This
cover
mechanics
procedures
as
well
their
utilization
therapeutics.
paper
then
summarizes
existing
knowledge
investigates
limitations
promise
aims
provide
researchers
an
overview
technological
development
It
serves
guide
integrating
future
nanomedicine
applications.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 6757 - 6776
Опубликована: Июль 1, 2024
Abstract:
Glioma
is
a
primary
malignant
tumor
in
the
central
nervous
system.
In
recent
years,
treatment
of
glioma
has
developed
rapidly,
but
overall
survival
patients
not
significantly
improved.
Due
to
presence
blood–brain
barrier
and
intracranial
barrier,
many
drugs
with
good
effects
cure
vitro
cannot
be
accurately
transported
corresponding
lesions.
order
enable
anti-tumor
overcome
barriers
target
glioma,
nanodrug
delivery
systems
have
emerged
recently.
It
gratifying
that
liposomes,
as
multifunctional
carrier,
which
can
compatible
hydrophilic
hydrophobic
drugs,
easily
functionalized
by
various
targeted
ligands,
biodegradable,
hypoimmunogenic
vivo,
become
quality
choice
solve
intractable
problem
medication.
Therefore,
we
focused
on
liposome
system,
summarized
its
current
research
progress
glioma.
Hopefully,
this
review
may
provide
new
ideas
for
development
liposome-based
nanomaterials
clinical
Keywords:
blood‒brain
nanomaterials,
liposome,
nanoparticle
drug
system
Neurobiology of Stress,
Год журнала:
2025,
Номер
34, С. 100707 - 100707
Опубликована: Янв. 1, 2025
Stress
plays
a
significant
role
in
the
onset
of
numerous
psychiatric
disorders.
Depending
on
individual
resilience
or
stressor's
nature,
long-term
changes
to
stress
brain
can
lead
wide
range
behavioral
symptoms,
including
social
withdrawal,
feelings
helplessness,
and
emotional
overeating.
The
receptor
molecules
are
key
mediators
these
processes,
translating
neuromodulatory
signals
into
neuronal
responses
circuit
activity
that
ultimately
shape
outcomes.
Here,
I
highlight
several
my
previous
studies
reveal
pivotal
critical
regions
such
as
nucleus
accumbens,
lateral
hypothalamus,
septum.
identified
how
mGluR5
signaling
accumbens
promotes
through
pathways
involving
ΔFosB
SRF,
while
leptin
glucocorticoid
within
hypothalamic
circuits
contributes
eating.
Additionally,
uncovered
dopamine
3
septum
mediating
impact
early
life
behaviors.
These
findings
underscore
functional
relevance
transducing
stress-from
adulthood-into
maladaptive
coping
As
druggable
targets,
receptor-mediated
provide
foundation
for
developing
targeted
interventions
alleviate
stress-related
symptoms.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12613 - 12613
Опубликована: Ноя. 24, 2024
Neurodegenerative
diseases,
such
as
Alzheimer's,
Parkinson's,
ALS,
and
Huntington's,
remain
formidable
challenges
in
medicine,
with
their
relentless
progression
limited
therapeutic
options.
These
diseases
arise
from
a
web
of
molecular
disturbances-misfolded
proteins,
chronic
neuroinflammation,
mitochondrial
dysfunction,
genetic
mutations-that
slowly
dismantle
neuronal
integrity.
Yet,
recent
scientific
breakthroughs
are
opening
new
paths
to
intervene
these
once-intractable
conditions.
This
review
synthesizes
the
latest
insights
into
underlying
dynamics
neurodegeneration,
revealing
how
intertwined
pathways
drive
course
diseases.
With
an
eye
on
most
promising
advances,
we
explore
innovative
therapies
emerging
cutting-edge
research:
nanotechnology-based
drug
delivery
systems
capable
navigating
blood-brain
barrier,
gene-editing
tools
like
CRISPR
designed
correct
harmful
variants,
stem
cell
strategies
that
not
only
replace
lost
neurons
but
foster
neuroprotective
environments.
Pharmacogenomics
is
reshaping
treatment
personalization,
enabling
tailored
align
individual
profiles,
while
diagnostics
biomarkers
ushering
era
early,
precise
disease
detection.
Furthermore,
novel
perspectives
gut-brain
axis
sparking
interest
mounting
evidence
suggests
microbiome
modulation
may
play
role
reducing
neuroinflammatory
responses
linked
neurodegenerative
progression.
Taken
together,
advances
signal
shift
toward
comprehensive,
personalized
approach
could
transform
care.
By
integrating
techniques,
this
offers
forward-looking
perspective
future
where
treatments
aim
just
manage
symptoms
fundamentally
alter
progression,
presenting
renewed
hope
for
improved
patient
outcomes.
