Military Medical Research,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 3, 2025
Abstract
Bone
tissue
relies
on
the
intricate
interplay
between
blood
vessels
and
nerve
fibers,
both
are
essential
for
many
physiological
pathological
processes
of
skeletal
system.
Blood
provide
necessary
oxygen
nutrients
to
bone
tissues,
remove
metabolic
waste.
Concomitantly,
fibers
precede
during
growth,
promote
vascularization,
influence
cells
by
secreting
neurotransmitters
stimulate
osteogenesis.
Despite
critical
roles
components,
current
biomaterials
generally
focus
enhancing
intraosseous
vessel
repair,
while
often
neglecting
contribution
nerves.
Understanding
distribution
main
functions
in
is
crucial
developing
effective
engineering.
This
review
first
explores
anatomy
highlighting
their
vital
embryonic
development,
metabolism,
repair.
It
covers
innovative
regeneration
strategies
directed
at
accelerating
intrabony
neurovascular
system
over
past
10
years.
The
issues
covered
included
material
properties
(stiffness,
surface
topography,
pore
structures,
conductivity,
piezoelectricity)
acellular
biological
factors
[neurotrophins,
peptides,
ribonucleic
acids
(RNAs),
inorganic
ions,
exosomes].
Major
challenges
encountered
neurovascularized
materials
clinical
translation
have
also
been
highlighted.
Furthermore,
discusses
future
research
directions
potential
developments
aimed
producing
repair
that
more
accurately
mimic
natural
healing
tissue.
will
serve
as
a
valuable
reference
researchers
clinicians
novel
into
practice.
By
bridging
gap
experimental
practical
application,
these
advancements
transform
treatment
defects
significantly
improve
quality
life
patients
with
bone-related
conditions.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
The
cartilage
possesses
limited
regenerative
capacity,
necessitating
advanced
approaches
for
its
repair.
This
study
introduces
a
bioink
designed
tissue
engineering
(TE)
by
incorporating
ionically
cross-linkable
alginate
into
the
photo-cross-linkable
MuMA
bioink,
resulting
in
double
cross-linked
interpenetrating
network
(IPN)
hydrogel.
Additionally,
hyaluronic
acid
(HA),
natural
component
of
and
synovial
fluid,
was
added
to
enhance
scaffold's
properties.
HA
has
been
demonstrated
improve
lubrication,
regulate
inflammation,
promote
cell
proliferation,
support
extracellular
matrix
(ECM)
deposition
regeneration,
making
it
valuable
TE.
Comprehensive
experiments
were
conducted
assess
morphology,
swelling,
degradation,
mechanical
rheological
properties,
printability,
biocompatibility.
Results
indicated
that
scaffolds
comprising
MuMA,
alginate,
exhibited
compressive
moduli
comparable
native
cartilage,
unlike
single
variants.
cross-linking
also
influenced
water
uptake,
porosity,
contributing
scaffold
durability
stability
chondrocyte
support.
Biocompatibility
tests
with
C28/I2
cells
cell-supportive
chondrogenic
potential
bioink.
establishes
mucin
as
versatile
material
specialized
applications.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2024,
Номер
163, С. 106848 - 106848
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 8, 2024
Abstract
Mobilizing
endogenous
progenitor
cells
to
repair
damaged
tissue
in
situ
has
the
potential
revolutionize
field
of
regenerative
medicine,
while
early
establishment
a
vascular
network
will
ensure
survival
newly
generated
tissue.
In
this
study,
gene‐activated
scaffold
containing
stromal
derived
factor
1α
plasmid
(pSDF1α),
pro‐angiogenic
gene
that
is
also
thought
be
involved
recruitment
mesenchymal
(MSCs)
sites
injury
described.
It
shown
over‐expression
SDF1α
protein
enhanced
MSC
and
induced
vessel‐like
structure
formation
by
endothelial
vitro.
When
implanted
subcutaneously,
transcriptomic
analysis
reveals
MSCs
are
recruited
significant
angiogenesis
stimulated.
Just
1‐week
after
implantation
into
calvarial
critical‐sized
bone
defect,
pSDF1α‐activated
scaffolds
rapidly
activate
angiogenic
osteogenic
programs,
upregulating
Runx2
,
Dlx5
Sp7
.
At
same
time‐point,
pVEGF‐activated
variety
cell
types,
activating
endochondral
ossification.
The
response
both
leads
complete
bridging
defects
within
4‐weeks.
versatile
cell‐free
described
study
capable
harnessing
enhancing
body's
own
capacity
immense
myriad
applications.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Biomaterials
have
experienced
significant
growth
in
recent
decades.
Porous
biomaterials
demonstrated
the
ability
to
create
intricate
spatial
configurations
with
three
dimensions,
duplicate
physical
characteristics
of
natural
tissues,
enhance
transport
large
molecular
structures
and
cells
through
interconnected
structures,
serve
as
biologically
compatible
implants
that
may
or
not
interact
host
organism.
This
section
will
present
a
historical
perspective
on
evolution
discuss
latest
advancements
production
porous
biomaterials.
The
utilization
these
materials
spans
wide
range
clinical
applications,
along
their
associated
benefits
obstacles.
Advanced NanoBiomed Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 16, 2025
Treatment
of
critical‐sized
bone
defects
remains
challenging
despite
bone's
regenerative
capacity.
Herein,
a
combination
biodegradable
polymer
possessing
bone‐bonding
properties
with
bioactive
β‐tricalcium
phosphate
(βTCP)
particles
coated
osteogenic
(Zinc)
and
angiogenic
(copper
or
cobalt)
ions
has
been
proposed.
βTCP
was
zinc
copper
(Zn/Cu)
cobalt
(Zn/Co)
using
15
mM
(low)
45
(high)
metallic
ion
solutions.
Composites
were
obtained
by
the
poly(ethylene
oxide
terephthalate)/poly(butylene
terephthalate)
(PEOT/PBT)
copolymer
in
50:50
ratio.
additively
manufactured
into
3D
porous
scaffolds
their
evaluated
direct
culture
human
mesenchymal
stromal
cells
(hMSCs)
as
well
an
indirect
coculture
umbilical
vein
endothelial
(HUVECs).
We
hypothesized
that
Zn/Cu
Zn/Co
form
coating
would
stimulate
both
PEOT/PBT‐βTCP
scaffolds.
In
addition,
we
investigated
whether
resulting
biomaterials
influenced
paracrine
function
hMSCs.
successfully
co‐incorporated
ceramic
without
changing
its
chemistry.
Scaffolds
containing
low
concentrations
increased
expression
RUNX2,
OCN,
OPN,
while
enhanced
ALPL.
On
protein
level,
high
elevated
ALP
collagen
production.
Angiogenic
improved
VEGFA
hMSCs
branching
tubules
formed
HUVECs,
particularly
Zn/Co.
also
cytokine
chemokine
secretion,
suggesting
effects.
Diseases,
Год журнала:
2025,
Номер
13(3), С. 75 - 75
Опубликована: Март 3, 2025
Pseudoarthrosis—the
failure
of
normal
fracture
healing—remains
a
significant
orthopedic
challenge
affecting
approximately
10–15%
long
bone
fractures,
and
is
associated
with
pain,
prolonged
disability,
repeated
surgical
interventions.
Despite
extensive
research
into
the
pathophysiological
mechanisms
healing,
diagnostic
approaches
remain
reliant
on
clinical
findings
radiographic
evaluations,
little
innovation
in
tools
to
predict
or
diagnose
non-union.
The
present
review
evaluates
current
understanding
genetic
biological
basis
pseudoarthrosis
highlights
future
directions.
Recent
studies
have
highlighted
potential
specific
molecules
markers
serve
as
predictors
unsuccessful
healing.
Alterations
mesenchymal
stromal
cell
(MSC)
function,
including
diminished
osteogenic
increased
cellular
senescence,
are
central
pathogenesis.
Molecular
analyses
reveal
suppressed
morphogenetic
protein
(BMP)
signaling
elevated
levels
its
inhibitors,
such
Noggin
Gremlin,
which
impair
regeneration.
Genetic
uncovered
polymorphisms
BMP,
matrix
metalloproteinase
(MMP),
Wnt
pathways,
suggesting
predisposition
Additionally,
differences
between
atrophic
hypertrophic
pseudoarthrosis,
variations
vascularity
inflammatory
responses,
emphasize
need
for
targeted
management.
Emerging
biomarkers,
circulating
microRNAs
(miRNAs),
cytokine
profiles,
blood-derived
MSCs,
other
(B7-1
PlGF-1),
contribute
early
detection
at-risk
patients
personalized
therapeutic
approaches.
Advancing
our
underpinnings
essential
development
innovative
strategies.
