A Green, Versatile, and Facile Strategy for Anti-biofouling Surface with Ultra-high Graft Density Polyethylene Glycol DOI Creative Commons

Wenjie Liu,

Suqin He, Hao Liu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Abstract Implantable catheters are susceptible to severe complications due non-specific protein adhesion on their surfaces. Polyethylene glycol (PEG) coatings, the gold standard for resistance adhesion, present a challenge in achieving high-density grafting, which significantly restricts use as anti-biofouling coatings. Herein, we exploited strong interaction between polyphenols (PCs) and polycations (K6-PEG) graft PEG onto surface of PC-Cu (A network metal composed proanthocyanidins copper ions, with expectation coating excellent (PC-Cu@K6-PEG). The introduction K6-PEG resulted enhanced stability modulus PC-Cu, well reduction energy contact angle PC-Cu. In contrast previously reported PC-Cu@K6-PEG exhibited markedly elevated grafting density (4.06 chains/nm²), was more than double highest value documented (1.9 diffusing ability throughout networks. displays robust variety proteins, microbials, platelet attachment, thereby preventing thrombosis. diverse substrates, coupled simple, straightforward environmentally benign process fabricating PC-Cu@K6-PEG, suggests that this strategy has significant potential

Язык: Английский

Nature-Inspired Surface Modification Strategies for Implantable Devices DOI Creative Commons
Sei‐Young Lee, Sungjae Yoo,

Sung Hoon Kim

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101615 - 101615

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

3
A strategy of de novo peptides for customizing supramolecular self-assembly coating with desired biological functionalities DOI
Na Li, Zeyu Shou,

Wenjie Liu

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 154058 - 154058

Опубликована: Июль 18, 2024

Язык: Английский

Процитировано

11
Immobilizing c(RGDfc) on the surface of metal-phenolic networks by thiol-click reaction for accelerating osteointegration of implant DOI Creative Commons
Zeyu Shou, Zhibiao Bai,

Kaiyuan Huo

и другие.

Materials Today Bio, Год журнала: 2024, Номер 25, С. 101017 - 101017

Опубликована: Март 3, 2024

The limited osteointegration often leads to the failure of implant, which can be improved by fixing bioactive molecules onto surface, such as arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Metal-Phenolic Networks (MPNs) have garnered increasing attention from different disciplines in recent years due their simple and rapid process for depositing on various substrates or particles with shapes. However, lack cellular binding sites MPNs greatly blocks its application tissue engineering. In this study, we present facile efficient approach producing PC/Fe@c(RGDfc) composite coatings through conjugation c(RGDfc) peptides surface PC/Fe-MPNs utilizing thiol-click reaction. By combined techniques (ellipsometry, X-ray photoelectron spectroscopy, Liquid Chromatography-Mass Spectrometry, water contact angle, scanning electronic microscopy, atomic force microscopy) physicochemical properties (composition, coating mechanism process, modulus hydrophilicity) were characterized detail. addition, exhibits remarkable ability positively modulate attachment, proliferation, migration promoted bone-implant integration vivo, maintaining inherent features MPNs: anti-inflammatory, anti-oxidative properties, well multiple substrate deposition. This work contributes engineering MPNs-based reaction, an innovative perspective future development modification implant materials.

Язык: Английский

Процитировано

4
Enhancing the Implant Osteointegration via Supramolecular Co‐Assembly Coating with Early Immunomodulation and Cell Colonization DOI Creative Commons
Chenglong Wang, Zeyu Shou, Chengwei Xu

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract Osteointegration, the effective coupling between an implant and bone tissue, is a highly intricate biological process. The initial stages of bone‐related immunomodulation cellular colonization play crucial roles, but have received limited attention. Herein, novel supramolecular co‐assembled coating strontium (Sr)‐doped metal polyphenol networks (MPN) modified with c(RGDfc) developed well‐characterized, for eliciting early colonization. results showed that (Sr‐MPN)@RGD significantly regulated polarization macrophages to M2 phenotype by controllable release Sr, promote adhesion marrow mesenchymal stem cells (BMSCs) RGD presented on MPN. Notably, attenuated osteoclast differentiation oxidative stress as well enhanced osteoblast angiogenesis due macrophage toward phenotype, which in turn has profound effect neighboring through paracrine signaling. In vivo manifested superior osseointegration maturation bare Ti‐rod or coated MPN Sr‐MPN. This work contributed design multifunctional coatings address complex process osteointegration from perspective orchestrating cell recruitment immunomodulatory strategies.

Язык: Английский

Процитировано

0
The De Novo Strategy for Bifunctional Peptides Coating to Enhance Osteointegration Capacity of the Implant DOI
Siwang Hu, Zeyu Shou, Chengwei Xu

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114642 - 114642

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis DOI Creative Commons
Dong Yang, Chang Shu, Chengwei Xu

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract Osteomyelitis represents a significant health concern, characterized by bacterial infection that can potentially present considerable challenge to clinical treatment. Current treatment strategies, including prolonged antibiotic regimens and surgical debridement, often fail adequately resolve or support bone regeneration, largely due the pathogen‐induced dysregulation of microenvironment. This study reports multifunctional capsule achieves coordinated capture‐killing immunomodulatory within osseous tissue, effectively resolving dual pathological challenges persistent microenvironment dysregulated regeneration inherent osteomyelitis. The capsules, PC‐O@TOB, are based on Schiff base reaction procyanidins (PC) with amino Lysine6‐osteogenic growth peptide (K6‐OGP) tobramycin (TOB), which allows for efficient loading controllable release K6‐OGP TOB. In vitro in vivo studies demonstrated PC‐O@TOB exhibits functionality: potent bactericidal activity through capture localized delivery, microenvironmental remodeling via ROS scavenging M2 macrophage polarization. effect synergizes capsule's osteogenic angiogenic properties accelerate repair. strategy antibacterial later has opened up new way

Язык: Английский

Процитировано

0
Endowing implants surface with enhanced vascularization and osseointegration via presenting triple-functional peptides DOI Creative Commons

Wenjie Liu,

Qing Wang, Hao Liu

и другие.

Journal of Orthopaedic Translation, Год журнала: 2025, Номер 52, С. 150 - 166

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
Dual-functional titanium implants via polydopamine-mediated lithium and copper co-incorporation: synergistic enhancement of osseointegration and antibacterial efficacy DOI Creative Commons
Jun Li, Bo Jiang, Liu Yang

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Май 12, 2025

Orthopedic implant failure due to inadequate osseointegration and infection remains a critical challenge. To address this, we engineered polydopamine (PDA)-mediated dual-functional platform for lithium (Li+) copper (Cu2+) co-incorporation on titanium alloy (Ti6Al4V) implants, aiming synergize osteogenic antibacterial properties through scalable surface modification strategy. PDA coatings were polymerized onto polished Ti64 substrates, followed by sequential immersion in LiCl (800 μM) CuCl2 (10 solutions construct Li+/Cu2+ co-doped surfaces (PDA@Li 800-Cu 10). In vitro assays assessed MC3T3-E1 pre-osteoblast proliferation (CCK-8), differentiation (ALP activity, RT-PCR ALP/Axin2), activity against S. aureus E. coli (live/dead staining, CFU assays). vivo efficacy was evaluated rat femoral defect model via micro-CT histology. Li+-functionalized 800) enhanced osteoblast osteogenesis Wnt/β-catenin activation. Cu2+-loaded (PDA@Cu 10) eradicated >99% bacteria but moderately suppressed markers. The dual-doped PDA@Li 10 resolved this bioactivity conflict, maintaining comparable PDA@Cu while elevating the capacity of Cu2+-only modified surfaces. vivo, dual-modified implants eliminated bacterial colonization within 72 h significantly increased peri-implant bone volume (BV/TV) comparison controls, outperforming PDA-only counterparts. By harmonizing Li-driven osteoinduction Cu-mediated bactericidal action platform, work advances transformative strategy next-generation orthopedic dental simultaneously addressing risks regeneration demands.

Язык: Английский

Процитировано

0
The use of supramolecular systems in biomedical applications for antimicrobial properties, biocompatibility, and drug delivery DOI
Yijie Li, Nihal Engin Vrana, Baptiste Letellier

и другие.

Biomedical Materials, Год журнала: 2024, Номер 19(4), С. 042005 - 042005

Опубликована: Май 11, 2024

Supramolecular chemistry is versatile for developing stimuli-responsive, dynamic and multifunctional structures. In the context of biomedical engineering applications, supramolecular assemblies are particularly useful as coatings they can closely mimic natural structure organisation extracellular matrix (ECM), also fabricate other complex systems like drug delivery bioinks. current growing medical device-associated complications developments in controlled regenerative medicine fields, becoming an indispensable part arsenal. This review covers different applications with a specific focus on antimicrobial coatings, that enhance biocompatibility, surface modifications implantable devices, promote therapeutic efficiency cancer therapy, development The introduced include multilayer coating by polyelectrolytes, polymers incorporated nanoparticles, simulation ECM, systems. A perspective application included.

Язык: Английский

Процитировано

1
Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities DOI Creative Commons

Kaiyuan Huo,

Wenjie Liu, Zeyu Shou

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Abstract Polyphenols and peptides represent two fundamental building blocks in the kingdom of supramolecular assembly (SA) coatings, which have recently attracted considerable interest. Regulating kinetics SA coatings is critical to controlling performance but this area still its infancy, especially coating peptide‐polyphenol. Herein, a library oligopeptides with rich diversity, numerous polyphenols, modulators are explored reveal their roles formation regulation coating. Citric acid (CA) an effective regulator interaction between polyphenols produce peptide‐polyphenol TCP. The electrostatic tannic (TA) cationic peptide drives TCP, while multiple hydrogen bonds CA TA dominate kinetics. With optimized pH mass ratio TA, CA, peptide, thickness TCP deposits onto diverse substrates (glass, silica, titanium, polystyrene) ≈400 nm controllable multifunctional endowed via peptide‐coupled functional units, including enhanced cellular adhesion, elevated osteogenic capacity, anti‐protein adsorption, antimicrobial. This work contributes understanding functionalization coatings.

Язык: Английский

Процитировано

1