Lipoic acid coated AgNPs incorporating with hydrogel for synergistic photodynamic/Ag+ bactericidal

Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112023 - 112023

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent advances in microneedles for enhanced functional angiogenesis and vascular drug delivery

Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Фев. 25, 2025

Many therapeutic applications use the transdermal method to avoid severe restrictions associated with oral medication delivery. Given limitations of traditional drug delivery via skin, microneedle (MN) arrays have been reported be versatile and very efficient devices due their outstanding characteristics such as painless penetration, affordability, excellent medicinal efficacy, relative safety. MNs recently received increased attention for ability cure vascular illnesses hypertension thrombosis, well promote wound healing angiogenesis impact. The integrant manufacturing biodegradable material allows modification MN form release pattern, hence increasing flexibility In this review, we focused on recent improvements in MN-mediated administration protein peptide medicines improved functional therapy. We also provide an overview present MNs-mediated administration, particularly realm system disease Finally, current state clinical translation a forecast future progress are provided.

Язык: Английский

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Microneedle hierarchical structure construction for promoting multi-stage wound healing

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125474 - 125474

Опубликована: Март 1, 2025

Язык: Английский

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Gold nanocage-carbon nanodot composites activate ornidazole against biofilm infections through modulating the hypoxic microenvironment

Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 106222 - 106222

Опубликована: Март 1, 2025

Язык: Английский

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A dissolving microneedle patch provides minimally invasive riboflavin delivery and enhances corneal crosslinking in keratoconus therapy

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Corneal collagen cross-linking (CXL) is an effective surgical approach to halt the progression of keratoconus. A key challenge lies in maintaining epithelial integrity while achieving sufficient stromal riboflavin (RF) concentration ensure CXL efficacy. Additionally, efficacy under RF-mediated still has room for improvement. In this study, we developed a silk fibroin methacryloyl (SFMA)-based dissolvable microneedle (MN) system (termed RF/SFMA MNs). vitro and ex vivo experiments showed that MNs exhibited excellent mechanical strength, dissolution profile, drug release profile biocompatibility. vivo, were characterized by suitable corneal penetration capability through minimally invasive approach. with different RF concentrations (0-2%) tip lengths (330-800 µm) tested. 1% length 550 µm achieved permeation delivery depth within stroma. Furthermore, integrating SFMA into procedure allowed mediate multiple crosslinking events between collagen, resulting enhanced increase biomechanical strength compared conventional Epi-on Epi-off strategies. Over two-week observation period, MN-based biomechanics more effectively than CXL, arrangement without adverse effects on epithelium or endothelium. Therefore, MNs, designed efficacy, present promising innovative optimize treatment

Язык: Английский

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Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Diabetes mellitus is a prevalent chronic disease, often leading to complications, with wounds being among the most challenging. Impairment of CXCR4/CXCL12 signaling pathway, which plays key role in cell mobilization, migration, and angiogenesis, significantly hampers wound healing process diabetic patients. Modulation this pathway using CXCR4-targeted agents has shown promise restoring repair capabilities. Additionally, development responsive hydrogels capable adapting external stimuli offers powerful platform for drug delivery management. These hydrogels, when loaded CXCR4 agonists or antagonists, enable controlled release real-time therapeutic modulation. Integrating such existing strategies may provide an innovative effective solution overcoming challenges associated treatment.

Язык: Английский

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Rhein-chitosan in situ hydrogel promotes wound healing in diabetic mice

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134472 - 134472

Опубликована: Авг. 3, 2024

Язык: Английский

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Hyaluronic acid dissolving microneedle patch-assisted acupoint transdermal delivery of triptolide for effective rheumatoid arthritis treatment

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 24, 2024

Triptolide (TP), a major active component of the herb Tripterygium wilfordii Hook F, has been shown excellent pharmacological effects on rheumatoid arthritis. However, TP is prone to causing severe organ toxicity, which limits its clinical application. In recent years, microneedle technology provided new option for treatment arthritis due advantages efficient local transdermal drug delivery. this study, we constructed platform deliver locally joints, thereby enhancing penetration and reducing systemic toxicity. Additionally, investigated whether acupoint delivery can produce synergistic effect needles drugs. First, was loaded into microneedles using polyvinylpyrrolidone hyaluronic acid as matrix materials. Next, established rat adjuvant-induced (AIA) model evaluate therapeutic TP-loaded microneedles. The experiments showed that alleviated AIA rats' inflammatory response, joint swelling, bone erosion. there no significant difference in observed non-acupoint administration groups. conclusion, have safety, convenience, high efficacy over conventional routes, laying foundation system-based

Язык: Английский

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Emerging Technological Advancement for Chronic Wound Treatment and Their Role in Accelerating Wound Healing

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(11), С. 7101 - 7132

Опубликована: Окт. 28, 2024

Chronic wounds are a major healthcare burden and may severely affect the social, mental, economic status of patients. Any impairment in wound healing stages due to underlying factors leads prolonged time subsequently chronic wounds. Traditional approaches for treatment include dressing free local therapy, tissue engineering based scaffold therapies. However, traditional therapies need improvisation have been advanced through breakthrough technologies. The present review spans further gives an extensive account advancements Cutting edge technologies, such as 3D printing, which includes inkjet fused deposition modeling, digital light processing, extrusion-based microneedle array-based therapies, gene microRNAs (miRNAs) smart dressings real monitoring conditions assessment pH, temperature, oxygen, moisture, metabolites, their use planning better strategies discussed detail. future direction treatments that will aid lowering caused

Язык: Английский

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Antibacterial carboxymethyl chitosan hydrogel loaded with antioxidant cascade enzymatic system for immunoregulating the diabetic wound microenvironment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137539 - 137539

Опубликована: Ноя. 12, 2024

Язык: Английский

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