ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Язык: Английский
European Polymer Journal, Год журнала: 2024, Номер 211, С. 113026 - 113026
Опубликована: Апрель 8, 2024
Chronic diabetic wounds persist as a healthcare challenge and therefore require the use of innovative therapeutic approaches. Among emerging solutions, hydrogels stand out promising avenue for wound healing due to their unique properties versatile applications, capable addressing complex challenging microenvironment that characterizes such wounds. In this work, through detailed analysis relevant experimental studies, we highlight multifunctionality hydrogels, namely ability promote tissue attachment, prevent scarring, fight infection, attenuate inflammation, facilitate electrical signaling, control bleeding, repair damage autonomously, exhibit responses tailored specific characteristics. The collective findings from these studies emphasize attributes in challenges. By elucidating crucial insights, work seeks lay groundwork both academics industries development implementation effective hydrogel-based strategies can significantly improve outcomes, offering new hope patients suffering chronic
Язык: Английский
Процитировано
18
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104653 - 104653
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 686 - 714
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
2
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Abstract Biopolymer‐based hydrogels offer versatility in biomedical engineering due to their abundance, biocompatibility, tailorable properties, and environmental responsiveness. Realizing full potential requires understanding the molecular‐level design principles that govern macroscopic behavior. This review analyzes recent advances molecular of biopolymer‐based hydrogels, emphasizing innovative network strategies processing methods for precise control over material properties functions. How influences hydrogel behavior across multiple length scales are explored, focusing on: 1) strategies: approaches like double networks, interpenetrating supramolecular assemblies tailor mechanical responsive properties; 2) techniques: such as Hofmeister effect‐induced chain aggregating, cononsolvency‐based porous structure controlling, directional freezing‐induced alignment achieve hierarchical anisotropic structures. these influence critical strength, inner mass transportation, degradation discussed. The also covers advanced fabrication techniques leverage create complex, functional hydrogels. By elucidating relationships between architecture, methods, resulting this work aims provide a framework designing next‐generation with enhanced performance functionality various applications.
Язык: Английский
Процитировано
2
Theranostics, Год журнала: 2024, Номер 14(11), С. 4198 - 4217
Опубликована: Янв. 1, 2024
The utilization of extracellular vesicles (EVs) in wound healing has been well-documented.However, the direct administration free EVs via subcutaneous injection at sites may result rapid dissipation bioactive components and diminished therapeutic efficacy.Functionalized hydrogels provide effective protection, as well ensure sustained release bioactivity during process, making them an ideal candidate material for delivering EVs.In this review, we introduce mechanisms by which accelerate healing, then elaborate on construction strategies engineered EVs.Subsequently, discuss synthesis application delivery systems to enhance complicated healing.Furthermore, face wounds, functionalized with specific microenvironment regulation capabilities, such antimicrobial, anti-inflammatory, immune regulation, used loading EVs, potential approaches addressing these challenges.Ultimately, deliberate future trajectories outlooks, offering a fresh viewpoint advancement artificial intelligence (AI)-energized materials 3D bio-printed multifunctional hydrogel-based dressings biomedical applications.
Язык: Английский
Процитировано
13
Carbohydrate Polymers, Год журнала: 2024, Номер 348, С. 122845 - 122845
Опубликована: Окт. 17, 2024
Polysaccharide hydrogels, which can mimic the natural extracellular matrix and possess appealing physicochemical biological characteristics, have emerged as significant bioinks for 3D bioprinting. They are highly promising applications in tissue engineering regenerative medicine because of their ability to enhance cell adhesion, proliferation, differentiation a manner akin cellular environment. This review comprehensively examines fabrication methods, polysaccharide hydrogel-driven bioprinting, underscoring its potential engineering, drug delivery, medicine. To contribute pertinent knowledge future research this field, critically key aspects, including chemistry carbohydrates, manufacturing techniques, formulation bioinks, characterization polysaccharide-based hydrogels. Furthermore, explores primary advancements 3D-printed encompassing delivery systems with controlled release kinetics targeted therapy, along tissue-engineered constructs bone, cartilage, skin, vascular regeneration. The use these bioprinted hydrogels innovative fields, disease modeling screening, is also addressed. Despite notable progress, challenges, modulating properties polysaccharides, enhancing bioink printability mechanical properties, achieving long-term vivo stability, been highlighted.
Язык: Английский
Процитировано
10
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 8, 2024
Intraoral wounds represent a particularly challenging category of mucosal and hard tissue injuries, characterized by the unique structures, complex environment, distinctive healing processes within oral cavity. They have common occurrence yet frequently inflict significant inconvenience pain on patients, causing serious decline in quality life. A variety novel functional dressings specifically designed for moist dynamic environment been developed realized accelerated improved wound healing. Thoroughly analyzing summarizing these materials is paramount importance enhancing understanding proficiently managing intraoral wounds. In this review, particular characteristics are firstly described. Up-to-date knowledge various forms, properties, applications existing products then intensively discussed, which categorized into animal products, plant extracts, natural polymers, synthetic products. To conclude, review presents comprehensive framework currently available dressings, with an aim to provoke inspiration future studies design more convenient versatile materials.
Язык: Английский
Процитировано
8
Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 20
Опубликована: Янв. 19, 2025
Objective
Язык: Английский
Процитировано
1
MedComm, Год журнала: 2024, Номер 5(10)
Опубликована: Сен. 21, 2024
Organoids are miniature, highly accurate representations of organs that capture the structure and unique functions specific organs. Although field organoids has experienced exponential growth, driven by advances in artificial intelligence, gene editing, bioinstrumentation, a comprehensive overview organoid applications remains necessary. This review offers detailed exploration historical origins characteristics various types, their applications-including disease modeling, drug toxicity efficacy assessments, precision medicine, regenerative medicine-as well as current challenges future directions research. have proven instrumental elucidating genetic cell fate hereditary diseases, infectious metabolic disorders, malignancies, study processes such embryonic development, molecular mechanisms, host-microbe interactions. Furthermore, integration technology with intelligence microfluidics significantly advanced large-scale, rapid, cost-effective thereby propelling progress medicine. Finally, advent high-performance materials, three-dimensional printing technology, also gaining prominence Our insights predictions aim to provide valuable guidance researchers support continued advancement this rapidly developing field.
Язык: Английский
Процитировано
6
Bioactive Materials, Год журнала: 2024, Номер 43, С. 240 - 254
Опубликована: Сен. 25, 2024
Язык: Английский
Процитировано
6