Polysaccharide- and protein-based hydrogel dressings that enhance wound healing: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135482 - 135482

Опубликована: Сен. 1, 2024

Язык: Английский

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Ultrasmall gold Nanoparticles/Carboxymethyl chitosan composite hydrogel: Tough, restorable, biocompatible antimicrobial dressing for wound healing

Applied Materials Today, Год журнала: 2024, Номер 38, С. 102206 - 102206

Опубликована: Май 16, 2024

Bacterial infection is one of the most challenging tasks in biomedical fields and still remains a serious threat to human lives today. Antibacterial hydrogel has attracted increasing scholarly interest as promising wound dressing material. The antibacterial properties ultrasmall gold nanoparticles (UsAuNPs) have also been widely recognized. Developing tensile, self-healable, biocompatible composite with desirable facilitate recovery essential improve treatment outcomes. However, UsAuNPs self-aggregate easily, resulting decreased effectiveness limited clinical application. To address this problem, material, carboxymethyl chitosan (UsAuNPs@CMCS) was designed. CMCS limit self-aggregation (AuNPs) at size 1–3 nm attracts bacteria carrying negative charge on surface, which renders high efficacy When crosslinked highly compatible polyacrylic acid (PAA) backbone hydrogel, PAA-CMCS-Au displayed facilitated vivo. This research establishes new strategy prevent UsAuNPs, provides insights treating wounds hydrogels.

Язык: Английский

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Fabrication and Characterization of Multi‐Stimuli‐Responsive Hydrogels with Robust Mechanical Properties, Good Self‐Healing, and Substrate Adhesiveness Using a Traditional Chemical Crosslinker and Initiator‐Free Approach

Macromolecular Chemistry and Physics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract Hydrogels are essential in various applications, including biomedical fields, robotics, sensors, and wearable technologies. Traditional fabrication methods often involve chemical crosslinkers initiators, which can introduce toxicity limit practical use. This study presents an innovative approach to creating multifunctional, multi‐stimuli‐responsive hydrogels without using these traditional components. By polymerizing AMPS, DMAA, MAA monomers environmentally friendly AlCl 3 ·6H 2 O as a crosslinker via UV polymerization, the produces exhibiting good mechanical properties such tensile strength (3.02 ± 0.12 MPa), toughness (20.01 1.8 J m −3 ), superior stretchability (2182.4 114% elongation), compression resistance addition possessing self‐healing capabilities, ionic conductivity, responsiveness temperature, pH, strength. technique represents significant advancement toward developing sustainable suitable for diverse biomedical, robotic, sensor, technology applications.

Язык: Английский

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Oxidized regenerated cellulose-based supermolecular hydrogel for controlled drug release: Integrating cyclodextrin-mediated hydrophobic drug distribution, wound-specific degradation, and multifunctional therapeutic effects

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143445 - 143445

Опубликована: Апрель 1, 2025

Язык: Английский

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Self-healing hyaluronic acid/polylysine hydrogel prepared by dual-click chemistry from polyrotaxane slidable crosslinkers

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 680, С. 157 - 172

Опубликована: Ноя. 16, 2024

Язык: Английский

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