Sea-Island Micelle Structured Hydrogel Scaffold: A Dual-Action Approach to Combat Cartilage Damage under RA Conditions

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(2), С. 2911 - 2923

Опубликована: Янв. 2, 2025

Rheumatoid arthritis (RA) is a common autoimmune joint disease characterized by persistent synovial inflammation and cartilage damage. The current clinical treatments primarily utilize drugs such as triptolide (TP) to address inflammation, yet they are unable directly repair damaged cartilage. Furthermore, the often undermines effectiveness of traditional strategies, preventing them from achieving optimal outcomes. To tackle this challenge, study successfully developed drug-loaded polyurethane hydrogel-oriented porous scaffold, designed facilitate under RA conditions. A hydrogel was formed via solvent-induced polyurethane-gelatin, resulting in scaffold TP@GSPU. sea-island micelle structure TP@GSPU enables efficient loading TP. release TP vivo environment regulates expression inflammatory factors macrophages, thereby improving microenvironment within cavity. Additionally, gelatin component provides robust support for regeneration. efficacy regulating facilitating conditions, which demonstrated through damage experiments conducted rat collagen-induced (CIA) model. design scheme material offers potential approach conditions RA.

Язык: Английский

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pH and ROS Dual‐Responsive Core‐Cross‐Linked Micelles Based on Boronic Ester Linkage for Efficient PTX Delivery

Journal of Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

ABSTRACT Micelle‐based drug delivery systems (DDS) have emerged as a promising solution to address challenges associated with the in vivo of hydrophobic anticancer chemotherapeutics. However, micelles still encounter issues such pre‐leakage and poor stability physiological conditions. To overcome these limitations, we developed core‐cross‐linking strategy utilizing amphiphilic copolymers, mPEG‐ b‐ P(AVL‐ co ‐LA) (mPPAL), functionalized phenylboronic acid (PBA), catechol by CuAAc “click” chemistry, respectively. These copolymers self‐assembled into core‐cross‐linked (CLMs), featuring boronic ester bonds, which were characterized through series evaluations. The CLMs exhibited rational particle size, uniform morphology, low critical micelle concentration (CMC), high PTX loading capacity, excellent stability. Two micelles, CLM1 CLM3, identified, their responsiveness acidic pH elevated levels ROS was confirmed enable controlled release. results MTT assay hemolytic analysis demonstrated biocompatibility potential application selected CLMs. efficacy PTX‐CLMs further validated 3D tumor spheroid studies. Fluorescence microscopy flow cytometry rapid intracellular uptake In biodistribution studies successful accumulation targeted tissue. findings suggest that ester‐based this study are nanocarrier for effective delivery.

Язык: Английский

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Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis

BME Frontiers, Год журнала: 2025, Номер 6

Опубликована: Янв. 1, 2025

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint swelling and bone destruction. Despite an incomplete understanding of its genesis, RA tightly linked to the intricate immunological milieu, involving disruptions in molecular signaling imbalance between innate adaptive immune systems. With advancements biomaterials science, role treatment has evolved from mere drug delivery systems therapeutic microenvironment modulators, providing drug-independent strategies for RA. In this review, we will delve into RA, focusing on contributions immunity, damage-associated patterns (DAMPs), cytokines, pathways disease’s pathogenesis inflammation. We provide detailed analysis applications novel nonpharmaceutical treatment, categorized 3 key mechanisms: biofactor pathway regulation, endogenous gas adjustment, cell modulation. The composition, form, principles, efficacy these be explored. thorough discussion topics offer fresh viewpoint guide future research directions.

Язык: Английский

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New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research

Gels, Год журнала: 2025, Номер 11(2), С. 136 - 136

Опубликована: Фев. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Язык: Английский

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A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

Abstract Insufficient oxygen supply and elevated levels of reactive species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation accelerate disease progression. In this study, a hybrid nanoassembly composed superoxide dismutase (SOD) catalase (CAT) conjugated within single poly(ε‐caprolactone) (PCL) nanoparticle is developed for RA therapy. The synthesized (PSC) drives proximity‐dependent cascade reaction that efficiently scavenges ROS generates oxygen, thereby modulating the phenotype inflammatory macrophages synovium, significantly inhibiting secretion pro‐inflammatory cytokines, consequently alleviating inflammation. Furthermore, PSC functions as versatile drug delivery platform hydrophobic small‐molecule drugs. Iguratimod (IGU), an anti‐rheumatic with bone‐protective properties, incorporated into (PSC@IGU), which then loaded dissolvable microneedles (MNs) to enhance efficiency. Finally, PSC@IGU MNs demonstrate significant therapeutic effects mouse models by effectively improving joint hypoxia, synovial inflammation, preventing bone erosion. This study highlights potential PSC@IGU‐loaded treatment RA, indicating their promising ability bridge basic research clinical translation.

Язык: Английский

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Alendronate and polyelectrolyte synergically induce biomimetic mineralization of collagen and demineralized dentin

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142402 - 142402

Опубликована: Март 1, 2025

Язык: Английский

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