Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101361 - 101361
Опубликована: Ноя. 22, 2024
Promoting
wound
nerve
regeneration
and
synchronously
initiating
angiogenesis
are
critical
factors
in
the
healing
process
of
diabetic
wounds.
However,
existing
research
on
wounds
mainly
focuses
angiogenesis,
bacterial
infection
reactive
oxygen
species,
often
failing
to
coordinate
neurogenesis
angiogenesis.
To
symbiosis
nerves
blood
vessels
wounds,
we
successfully
designed
a
multifunctional
chitosan
(CS)-based
sponges
by
regulating
structure
CS
specifically
for
healing.
This
sponge,
which
facilitates
effective
exudate
transfer
modulates
microenvironment,
was
constructed
using
hydroxybutyl
grafted
with
thioctic
acid
(TA),
named
as
HCT
sponge.
When
applied
humid
environment,
hydrophobic
side
chains
sponge
interact
self-assembled
domains,
forming
gel-sponge
composite.
Experimental
results
showed
that
adhesion
strength
wet
porcine
skin
70.3
kPa.
Additionally,
exhibited
favorable
degradability,
cytocompatibility
antioxidant
properties.
As
it
is
shown
experiments
vitro,
can
not
only
promote
cell
proliferation,
migration,
vessel
formation,
but
also
M2
macrophage
polarization.
Moreover,
rat
liver
femoral
artery
injury
model
validated
effectively
treat
heavy
bleeding
from
efficacy
through
quickly
sealing
formation
multiple
hemostatic
dams.
In
vivo
studies
indicated
significantly
accelerated
compared
recombinant
bovine
basic
fibroblast
growth
factor
gel,
achieving
better
recovery
after
15
days.
Pathological
show
novel
holds
considerable
promise
treating
wound,
allowing
regenerative
at
site,
provides
significant
potential
further
improving
clinical
applications.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
Black
phosphorus
(BP)
has
demonstrated
potential
as
a
drug
carrier
and
photothermal
agent
in
cancer
therapy;
however,
its
intrinsic
functions
treatment
remain
underexplored.
This
study
investigates
the
immunomodulatory
effects
of
polyethylene
glycol‐functionalized
BP
(BP‐PEG)
nanosheets
breast
models.
Using
immunocompetent
mouse
models‐including
4T1
orthotopic
BALB/c
mice
MMTV‐PyMT
transgenic
mice,
it
is
found
that
BP‐PEG
significantly
inhibits
tumor
growth
metastasis
without
directly
inducing
cytotoxicity
cells.
Mass
cytometry
analysis
reveals
reshapes
immune
microenvironment
by
recruiting
neutrophils.
Neutrophil
depletion
experiments
further
demonstrate
antitumor
are
dependent
on
Moreover,
bulk
single‐cell
RNA
sequencing
indicate
mainly
taken
up
macrophages,
leading
to
release
inflammatory
factors
such
IL1A
CXCL2,
which
enhance
neutrophil
recruitment
activation,
thereby
amplifying
response.
Finally,
co‐culture
assays
confirm
indeed
enhances
activity
neutrophils
natural
killer
(NK)
These
findings
position
an
capable
reprogramming
promote
innate
immunity
against
cancer.
By
stimulating
neutrophil‐mediated
activity,
offers
unique
therapeutic
approach
can
potentially
efficacy
existing
immunotherapies.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
Abstract
MXenes
exhibit
remarkable
properties,
including
high
electrical
conductivity,
tunable
surface
chemistry,
outstanding
mechanical
strength,
and
notable
hydrophilicity.
Recent
advancements
in
bio‐functionalization
have
further
enhanced
these
intrinsic
characteristics,
unlocking
unprecedented
opportunities
for
across
a
wide
spectrum
of
applications
both
biomedical
environmental
domains.
This
review
provides
an
in‐depth
analysis
the
synthesis
strategies
functionalization
techniques
that
improve
MXenes'
biocompatibility
expand
their
potential
uses
cutting‐edge
applications,
implantable
wearable
devices,
drug
delivery
systems,
cancer
therapies,
tissue
engineering,
advanced
sensing
technologies.
Moreover,
explores
utility
bio‐functionalized
areas
such
as
corrosion
protection,
water
purification,
food
safety
sensors,
underscoring
versatility
addressing
urgent
global
challenges.
By
conducting
critical
evaluation
current
research,
this
not
only
highlights
immense
but
also
identifies
pivotal
gaps
literature,
offering
clear
pathways
future
exploration
innovation
rapidly
evolving
field.
