Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 493, С. 117155 - 117155
Опубликована: Ноя. 12, 2024
Язык: Английский
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
The development of malignant tumors is a complex process that involves the tumor microenvironment (TME). An immunosuppressive TME presents significant challenges to current cancer therapies, serving as key mechanism through which cells evade immune detection and play crucial role in progression metastasis. This impedes optimal effectiveness immunotherapeutic approaches, including cytokines, checkpoint inhibitors, vaccines. Tumor-associated macrophages (TAMs), major component tumor-infiltrating cells, exhibit dual functionalities: M1-like TAMs suppress tumorigenesis, while M2-like promote growth Consequently, various nanocarriers aimed at polarizing phenotypes distinct mechanisms has emerged promising therapeutic strategy inhibit escape enhance antitumor responses. Review covers origin types TAMs, common pathways regulating macrophage polarization, progression, strategies targeting aiming provide comprehensive understanding guidance for future research clinical applications.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101555 - 101555
Опубликована: Фев. 4, 2025
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most feared diseases worldwide owing to its poor prognosis, negligible therapeutic advances, and high mortality. Herein, multifunctional enzyme-responsive micelles for controlled delivery paclitaxel (PTX) were prepared circumvent current clinical challenges. Accordingly, two structural units composed Vitamin D3 (VD3) conjugated with polyethylene glycol different molecular weights (600 Da 2000 Da) synthesized characterized using analytical methods. By applying solvent evaporation method, these bioactive self-assembled into sub-100 nm VD3 minimal batch-to-batch variation, monomodal particle size distribution, encapsulation efficiency. The enzyme-triggered disassembly PTX-loaded was demonstrated by release studies in presence a esterase content typically featured PDAC cells. also exhibited prominent cell internalization induced considerable cytotoxic synergistic effect against human cells (BxPC-3 cells) 2D 3D culture models compared free PTX. hemocompatible stable after long-term storage biorelevant media, showed higher efficiency inhibit tumor growth approved nanoformulation (Abraxane®) an ovo model. findings reported here indicate that VD3S-PEG may have promising role therapy, since could act not only as hydrophobic core but agent provides synergetic effects encapsulated
Язык: Английский
Процитировано
0
Gastroenterology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 4235 - 4255
Опубликована: Апрель 1, 2025
α-Solanine (α-Sol) shows promise for pancreatic cancer (PC) treatment by inhibiting PC cell proliferation, migration, and invasion. However, its clinical application is hindered poor tumor targeting, significant toxicity, undesirable pharmacokinetics. To address these issues, this study developed a nanoparticle delivery system (PBSO NPs) using bovine serum albumin as carrier, with polyallylamine hydrochloride surface modification to enhance α-Sol delivery. PBSO NPs were characterized transmission electron microscopy, dynamic light scattering, size analyzers, Fourier-transform infrared spectroscopy. Their in vitro drug release profile cellular uptake capabilities evaluated. Furthermore, experiments conducted mouse cells (Panc02) investigate the effects of on Panc02 viability, invasion, apoptosis. Additionally, xenograft model was established vivo explore impact growth. This successfully favorable morphology physiological stability, capable enhancing uptake. In demonstrated that significantly inhibited invasion while promoting Moreover, enhanced inhibitory cells. further confirmed improved therapeutic efficacy against partially reducing toxicity. exhibited good biocompatibility. apoptosis, thereby suppressing progression PC. provides promising strategy treatment.
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 4571 - 4587
Опубликована: Апрель 1, 2025
Topical application of 17β-estradiol (E2) has been shown to improve various hallmark features skin aging, including enhancing elasticity and hydration, reducing wrinkles, promoting collagen synthesis. However, the role estrogen in UVB-induced photoaging remains unclear. Furthermore, E2's clinical is limited by issues such as bioavailability potential adverse effects. Therefore, this study aims explore E2 prepare a gold (Au)@mesoporous polydopamine (mPDA)-hyaluronic acid (HA)/carboxymethyl chitosan (CMCS) nanoparticle composite hydrogel (Au/E2@mPDA-HCG) for treatment photoaging. This successfully fabricated mPDA with well-defined mesoporous structure incorporated Au NPs into mesopores using an situ growth method, thereby constructing Au@mPDA loaded E2. Subsequently, Au/E2@mPDA were embedded HA/CMCS develop Au/E2@mPDA-HCG hydrogel. The was characterized through vitro vivo experiments, its efficacy improving evaluated. revealed that deficiency significantly exacerbates photoaging, likely mechanisms closely associated increased oxidative stress reduced production. Moreover, demonstrated favorable morphological characteristics biocompatibility. In experimental results indicated effectively enhanced therapeutic treating evidenced significant mitigation inflammatory responses, along promotion conclusion, suggests combination Au@mPDA@HCG nanocomposite offers promising strategy
Язык: Английский
Процитировано
0
Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 493, С. 117155 - 117155
Опубликована: Ноя. 12, 2024
Язык: Английский
Процитировано
1