Biomedicines, Год журнала: 2025, Номер 13(3), С. 562 - 562
Опубликована: Фев. 24, 2025
Background/Objectives. Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, re-epithelialization, hinder healing process in chronic wounds. Many these processes are dependent on their interaction with copper. We hypothesized that targeted delivery copper ions to wound bed would enhance healing. Methods. Wound dressings impregnated oxide microparticles were designed ensure controlled release ions. The efficacy was evaluated using non-infected models, diabetic mouse models compared against control silver dressings. Outcome measures included closure rates, epidermal skin quality assessed histopathological examination, gene expression profiling. Clinical applications through diverse case studies trials involving management. Results. Copper significantly accelerated enhanced angiogenesis Histopathological analyses revealed faster granulation tissue formation, regeneration, neovascularization. Gene showed upregulation critical angiogenic factors VEGF HIF-1α. Investigations clinical observations corroborated improved across various types, Conclusions. is essential for healing, copper-impregnated provide promising solution By enhancing go beyond antimicrobial action, offering cost-effective innovative alternative conventional therapies. represent transformative advancement addressing challenges care.
Язык: Английский