Hemostatic and antimicrobial properties of chitosan-based wound healing dressings: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
306, С. 141570 - 141570
Опубликована: Фев. 27, 2025
Язык: Английский
Synthesis of Yttria Nanoparticle-Loaded Electrospun Nanofibers for Enhanced Antimicrobial Activity, Biofilm Inhibition, and Alleviation of Diabetic Wounds
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Diabetes-related
sores
and
ulcers
are
quite
common
around
the
world
can
cause
complicated
disruptions
to
both
patient
compliance
socioeconomic
structure.
Diabetic
wounds
take
longer
heal
due
pathophysiological
causes,
persistent
infections,
increasingly
severe
medical
problems.
Nanoparticles
(NPs)
derived
from
nanotechnology
have
drawn
interest
their
revolutionary
potential
in
understanding
biological
milieu
offering
therapeutic
strategies
for
wound
healing.
In
this
regard,
of
yttrium
oxide
nanoparticles
(YNPs)
has
been
studied
extensively
understand
efficacy
diabetic
Yttrium
having
size
range
2–10
nm
were
prepared
incorporated
into
nanofibrous
mats
consisting
polyurethane
as
matrix
polymer,
leaf
extract
Azadirachta
indica
clindamycin
hydrochloride
additive
conventional
antidiabetic
antibacterial
agents
form
S3.
Physicochemical
characterization
tests
confirmed
formation
nanofibers
average
diameters
320–470
nm,
respectively.
The
study
demonstrated
that
S3
shows
an
enhanced
zone
inhibition
against
E.
coli
(29
mm),
S.
aureus
(32
P.
aeruginosa
(30
mm).
Moreover,
also
prevented
microbial
penetration
biofilm
formation,
observed
MTT,
CV,
confocal
microscopy
images.
vivo
healing
conducted
on
mice
revealed
exhibited
high
contraction
after
9
days
treatment.
Additionally,
fabricated
mat
lowered
plasma
glucose
levels,
hepatotoxicity,
oxidative
stress
biomarkers.
Therefore,
it
be
concluded
YNP-loaded
composite
a
strong
alleviating
wounds.
Язык: Английский
Development of poly(lactic acid)/polyvinyl alcohol-based temperature-responsive shell-core nanofibers: Controlled release, biosafety evaluation, and application in raspberry preservation
Shuqiong Xia,
Mengjie Bian,
Hengyi Li
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
307, С. 142084 - 142084
Опубликована: Март 13, 2025
Язык: Английский
Biomimetic Piezoelectric Periosteum‐Bone Integrated Implant Promotes Bone Defect Repair by Remodeling Osteogenic Microenvironment
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Abstract
Bone
defects
caused
by
trauma,
infection,
or
tumors
pose
significant
clinical
challenges,
particularly
in
large
with
poor
healing
outcomes.
Traditional
repair
methods
often
fail
to
address
the
complex
regenerative
microenvironment.
This
study
introduces
a
novel
biomimetic
piezoelectric
periosteum‐bone
bilayer
implant
designed
remodel
osteogenic
microenvironment
and
enhance
bone
defect
repair.
The
comprises
an
upper
electrospun
polyvinylidene
fluoride‐curcumin‐loaded
magnesium
metal–organic
framework
(PVDF‐MOF/Cur,
PMC)
periosteum
scaffold
lower
hydroxyapatite@gelatin
methacrylate
(HA@GelMA)
(PMC+HA@GelMA,
PMCG).
In
whole
PMCG
implant,
PMC
improves
properties
of
PVDF
enables
sustained
drug
release
via
Mg‐MOF
loaded
Cur.
Meanwhile,
HA@GelMA
facilitates
marrow
mesenchymal
stem
cells
differentiation
regeneration.
Additionally,
further
accelerates
promoting
neuronal
differentiation,
as
well
enhancing
angiogenesis
regulating
macrophage
polarization.
Transcriptome
sequencing
reveals
that
activates
key
signaling
pathways
associated
angiogenesis,
neurogenesis,
inflammation
regulation,
osteogenesis,
including
HIF‐1α,
PI3K‐Akt,
JAK‐STAT,
TGF‐β
pathways.
Thus,
this
work
highlights
multifunctional
capabilities
remodify
accelerate
repair,
which
offers
promising
platform
for
advancing
tissue
Язык: Английский
Electrospun Chitosan-Coated Recycled PET Scaffolds for Biomedical Applications: Short-Term Antimicrobial Efficacy and In Vivo Evaluation
Polymers,
Год журнала:
2025,
Номер
17(8), С. 1077 - 1077
Опубликована: Апрель 16, 2025
This
study
investigates
the
preparation
of
electrospun
recycled
polyethylene
terephthalate
(rPET)
coated
with
chitosan
(CS)
and
evaluates
their
antibiofilm
properties
in
vivo
response.
rPET
scaffolds
were
first
fabricated
via
electrospinning
at
different
flow
rates
(10,
7.5,
5
2.5
mL/h)
subsequently
chitosan.
Scanning
electron
microscopy
(SEM)
revealed
that
fiber
morphology
varied
parameters,
influencing
microbial
adhesion.
Antimicrobial
tests
demonstrated
rPET@CS
significantly
inhibited
Staphylococcus
aureus,
Pseudomonas
aeruginosa
Candida
albicans
biofilm
formation
compared
to
control
uncoated
surfaces.
Subcutaneous
implantation
induced
a
transient
inflammatory
response,
macrophage
recruitment
collagen
deposition
supporting
tissue
integration.
These
findings
highlight
potential
as
sustainable
antimicrobial
biomaterials
for
applications
infection-resistant
coatings
biomedical
implants.
Язык: Английский
Tannic acid-etched PAN/PVP nanofibers loaded with Cu-MOFs enhance antibacterial efficacy and accelerate wound healing
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
253, С. 114719 - 114719
Опубликована: Апрель 18, 2025
Язык: Английский
Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Дек. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
Язык: Английский