Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13302 - 13302
Опубликована: Дек. 11, 2024
This
review
aims
to
address
the
significant
challenges
of
treating
central
nervous
system
(CNS)
disorders
such
as
neurodegenerative
diseases,
strokes,
spinal
cord
injuries,
and
brain
tumors.
These
are
difficult
manage
due
complexity
disease
mechanisms
protective
blood–brain
barrier
(BBB),
which
restricts
drug
delivery.
Recent
advancements
in
nanoparticle
(NP)
technologies
offer
promising
solutions,
with
potential
applications
delivery,
neuroprotection,
neuroregeneration.
By
examining
current
research,
we
explore
how
NPs
can
cross
BBB,
deliver
medications
directly
targeted
CNS
regions,
enhance
both
diagnostics
treatment.
Key
NP
strategies,
passive
targeting,
receptor-mediated
transport,
stimuli-responsive
systems,
demonstrate
encouraging
results.
Studies
show
that
may
improve
minimize
side
effects,
increase
therapeutic
effectiveness
models
Alzheimer’s,
Parkinson’s,
stroke,
glioblastoma.
thus
represent
a
approach
for
disorder
management,
combining
delivery
diagnostic
capabilities
enable
more
precise
effective
treatments
could
significantly
benefit
patient
outcomes.
Язык: Английский
Dynamic Col-HZ Hydrogel with Efficient Delivery of Bioactivator Promotes ECM Deposition and Cartilage Formation
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101623 - 101623
Опубликована: Фев. 28, 2025
Efforts
in
cartilage
tissue
engineering
to
repair
injuries
have
seen
limited
success,
primarily
due
the
inability
of
scaffold
materials
establish
a
microenvironment
conducive
extracellular
matrix
(ECM)
deposition
by
chondrocytes.
Hydrogels,
which
mimic
human
tissue,
are
commonly
employed
as
materials;
however,
their
constrained
network
structure
and
low
bioactivity
impede
chondrocyte
ECM
deposition,
complicating
repair.
In
this
study,
we
developed
dynamic
Col-HZ
hydrogels
featuring
adaptive
networks
forming
hydrazone
(HZ)
bonds
between
bioactive
natural
collagen
synthetic
polyethylene
glycol
(PEG).
contrast
static
that
rely
on
covalent
bonds,
facilitate
migration
deposition.
Additionally,
aldehyde
groups
hydrogel
can
engage
Schiff
base
bonding
with
amine
groups.
Leveraging
non-covalent
interaction,
incorporated
bioactivator
TD-198946,
known
enhance
synthesis,
into
hydrogel.
This
significantly
boosted
reduced
inflammation.
Transcriptomic
sequencing
bioinformatics
analyses
indicate
both
binding
TD-198946
promote
through
modulation
Wnt/β-catenin
signaling
pathway.
Consequently,
hydrogel,
combination
creates
an
improved
supports
facilitates
formation.
Язык: Английский
Editorial: Biomaterials and biologicals for disease treatment
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 10, 2025
Язык: Английский
Silver nanoparticle‐infused hydrogels for biomedical applications: A comprehensive review
Journal of the Chinese Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
Recent
advancements
in
biomedical
applications
have
highlighted
the
need
for
nontoxic
and
organic
materials
with
versatile
capabilities.
Silver
nanoparticles
(AgNPs)
emerged
as
a
promising
antimicrobial
agent
due
to
their
exceptional
physicochemical
properties,
whereas
hydrogels
offer
potential
biomedicine
biocompatibility,
biodegradability,
hydrophilicity.
AgNPs‐infused
hydrogel
can
synergistic
approach
various
applications,
specifically
wound
healing,
drug
delivery,
coatings.
The
incorporation
of
AgNPs
into
enhances
making
them
ideal
reducing
infections
promoting
tissue
regeneration.
Furthermore,
serve
controlled‐release
systems
therapeutic
agents,
which
ensures
sustained
targeted
delivery.
Most
importantly,
this
type
system
offers
pathway
overcoming
challenges
posed
by
traditional
materials.
While
significant
advantages
such
cytotoxicity,
environmental
concerns,
long‐term
effects
require
further
investigation.
Overall,
review
comprehensively
explores
synthesis
methods,
associated
hydrogel.
Язык: Английский