Chemistry & Biodiversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 3, 2025
Bone
trauma
presents
a
complex
clinical
challenge
requiring
simultaneous
management
of
inflammation,
infection
risk,
and
impaired
regeneration.
Conventional
therapies
often
address
these
issues
separately,
highlighting
the
need
for
multifunctional
agents
capable
integrated
therapeutic
action.
Limonene,
natural
monoterpene,
has
demonstrated
broad-spectrum
bioactivity,
but
its
potential
in
bone
therapy
remains
underexplored.
This
study
evaluates
limonene's
triple
properties:
(1)
Antibacterial
efficacy
against
Escherichia
coli
Staphylococcus
aureus;
(2)
Anti-inflammatory
effects
on
RAW
264.7
macrophages
under
lipopolysaccharide
stimulation;
(3)
Osteogenic
MC3T3-E1
osteoblasts
by
assessing
proliferation
osteogenic
gene
expression.
Limonene
concentration-dependent
antibacterial
efficacy,
with
significant
growth
inhibition
observed
both
Gram-positive
Gram-negative
pathogens.
Meanwhile,
limonene
exhibited
potent
anti-inflammatory
activity
macrophages,
as
evidenced
dose-dependent
suppression
key
pro-inflammatory
mediators,
including
interleukin-1β
inducible
nitric
oxide
synthase.
Notably,
osteoblasts,
significantly
upregulated
expression
collagen
alpha1
enhanced
osteocalcin
production
at
optimal
concentrations,
suggesting
dual
role
mitigating
inflammation
while
promoting
differentiation.
Collectively,
findings
highlight
candidate
repair,
meriting
further
investigation
through
vivo
studies
to
validate
translational
potential.
Polymers,
Год журнала:
2025,
Номер
17(8), С. 999 - 999
Опубликована: Апрель 8, 2025
This
study
presents
a
hybrid
hydrogel
system
designed
for
the
targeted
delivery
of
letrozole,
key
therapeutic
agent
in
breast
cancer
treatment.
Letrozole-loaded
poly(lactic-co-glycolic
acid)
(PLGA)
microparticles
were
embedded
within
poly(2-hydroxyethyl
methacrylate)
(pHEMA)
matrix
coated
onto
acrylamide-grafted
low-density
polyethylene
(AAm-g-LDPE),
yielding
mechanically
stable
with
tunable
drug
release.
Field
emission
scanning
electron
microscopy
(FE-SEM)
and
confocal
confirmed
uniform
microparticle
distribution.
In
vitro
release
studies
simulated
uterine
fluid
(SUF)
at
37
°C
demonstrated
sustained
profile
over
32
days,
reduced
initial
burst
effect
(~15%
lower
than
conventional
PLGA
systems).
The
system’s
kinetics
followed
Higuchi
model
(R2
=
0.803–0.996),
indicating
Fickian
diffusion.
offers
enhanced
stability,
dosing
frequency,
potential
personalized
hormone
therapy,
improving
patient
compliance,
particularly
individuals
physical
or
cognitive
impairments.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
chromogenic
hydrogel
sensor
containing
Au-Bead@Ag
nanorods
incorporated
inside
agarose
gel
for
visual
detection
of
ammonia
released
from
spoiled
food.
In
recent
years,
hydrogel
beads
and
in
situ
hydrogels
have
gained
wide
attention
various
fields
such
as
biomedicine.
this
study,
3-(4-hydroxyphenyl)
propionic
acid
(HP)
was
introduced
into
the
side
chain
of
poly(α,β-[N-(2-hydroxyethyl)-D,L-aspartamide])
(PHEA)
to
synthesize
phenolic
hydroxyl-functionalized
poly(aspartamide)
derivative
PHEA-HP
with
enzyme-catalyzed
cross-linking
potential.
First,
chemical
structure
characterized
by
FT-IR,
UV
1H
NMR,
results
vitro
cytotoxicity
against
L929
cell
line
hemolysis
experiment
showed
that
did
not
toxicity
cells
(viability
>
90%)
had
good
blood
compatibility.
Then,
rheological
measurement
confirmed
formation
PHEA-HP-based
a
high
storage
modulus
(G')
around
104
Pa,
vial-tilting
method
revealed
gelation
time
aqueous
solution
could
be
tuned
range
5-260
s
varying
concentrations
hydrogen
peroxide
(H2O2)
horseradish
peroxidase
(HRP).
Finally,
different
diameters
containing
methylene
blue
(for
easy
observation)
were
prepared
using
coaxial
needle
syringe
pumps,
effect
flow
rate
outer
phase
on
also
investigated.
Therefore,
may
promising
safe
can
used
prepare
for
applications
closely
related
human
body.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Abstract
Bone
defects
caused
by
trauma,
infection,
or
tumors
pose
significant
clinical
challenges,
particularly
in
large
with
poor
healing
outcomes.
Traditional
repair
methods
often
fail
to
address
the
complex
regenerative
microenvironment.
This
study
introduces
a
novel
biomimetic
piezoelectric
periosteum‐bone
bilayer
implant
designed
remodel
osteogenic
microenvironment
and
enhance
bone
defect
repair.
The
comprises
an
upper
electrospun
polyvinylidene
fluoride‐curcumin‐loaded
magnesium
metal–organic
framework
(PVDF‐MOF/Cur,
PMC)
periosteum
scaffold
lower
hydroxyapatite@gelatin
methacrylate
(HA@GelMA)
(PMC+HA@GelMA,
PMCG).
In
whole
PMCG
implant,
PMC
improves
properties
of
PVDF
enables
sustained
drug
release
via
Mg‐MOF
loaded
Cur.
Meanwhile,
HA@GelMA
facilitates
marrow
mesenchymal
stem
cells
differentiation
regeneration.
Additionally,
further
accelerates
promoting
neuronal
differentiation,
as
well
enhancing
angiogenesis
regulating
macrophage
polarization.
Transcriptome
sequencing
reveals
that
activates
key
signaling
pathways
associated
angiogenesis,
neurogenesis,
inflammation
regulation,
osteogenesis,
including
HIF‐1α,
PI3K‐Akt,
JAK‐STAT,
TGF‐β
pathways.
Thus,
this
work
highlights
multifunctional
capabilities
remodify
accelerate
repair,
which
offers
promising
platform
for
advancing
tissue
Tissue Engineering Part B Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
Platelet-rich
plasma
(PRP)
is
a
blood
product
with
higher
platelet
concentrations
than
whole
blood,
offering
controlled
delivery
of
growth
factors
(GFs)
for
regenerative
medicine.
PRP
plays
pivotal
roles
in
tissue
restoration
mechanisms,
including
angiogenesis,
fibroblast
proliferation,
and
extracellular
matrix
development,
making
it
applicable
across
various
medicine
treatments.
Despite
promising
results
different
injuries,
challenges
such
as
short
half-life
rapid
deactivation
by
proteases
persist.
To
address
these
challenges,
biomaterial-based
scaffolds,
sponges
or
hydrogels,
have
been
investigated.
Current
studies
exhibit
that
PRP-loaded
scaffolds
fix
issues
due
to
the
sustained
release
GFs.
In
this
regard,
given
widespread
application
clinical
studies,
use
has
drawn
significant
consideration
engineering
(TE).
Therefore,
review
briefly
introduces
rich
origin
GFs,
its
classification,
preparation
methods
discusses
applications
This
study
also
emphasizes
reviews
latest
research
on
using
diverse
fields
TE,
skin,
bone,
cartilage
repair.
