Pyruvate Regulates the Expression of DLAT to Promote Follicular Growth DOI Creative Commons

Liuhong Zhang,

Yixuan Guo,

Enyuan Huang

и другие.

Cells, Год журнала: 2025, Номер 14(6), С. 444 - 444

Опубликована: Март 17, 2025

Increasing evidence has suggested that dihydrolipoamide S-acetyltransferase (DLAT), a subunit of the pyruvate dehydrogenase complex, is crucial for metabolism and regulation cell death. The excessive death granulosa cells (GCs) hinders progression follicular growth. However, relationship between DLAT growth poorly understood. Here, we found significantly shortened age pubertal initiation in mice promoted by promoting proliferation GCs. In addition, up-regulated expression high level was observed large follicles, which were associated with Mechanistically, increased mRNA protein levels pathways such as PCNA MCL1 to promote GC proliferation. Additionally, bound CASP3 CASP9 proteins inhibit apoptosis Taken together, these results reveal mechanism regulated growth, represents promising target supports new strategies improving follicles.

Язык: Английский

Pyruvate Regulates the Expression of DLAT to Promote Follicular Growth DOI Creative Commons

Liuhong Zhang,

Yixuan Guo,

Enyuan Huang

и другие.

Cells, Год журнала: 2025, Номер 14(6), С. 444 - 444

Опубликована: Март 17, 2025

Increasing evidence has suggested that dihydrolipoamide S-acetyltransferase (DLAT), a subunit of the pyruvate dehydrogenase complex, is crucial for metabolism and regulation cell death. The excessive death granulosa cells (GCs) hinders progression follicular growth. However, relationship between DLAT growth poorly understood. Here, we found significantly shortened age pubertal initiation in mice promoted by promoting proliferation GCs. In addition, up-regulated expression high level was observed large follicles, which were associated with Mechanistically, increased mRNA protein levels pathways such as PCNA MCL1 to promote GC proliferation. Additionally, bound CASP3 CASP9 proteins inhibit apoptosis Taken together, these results reveal mechanism regulated growth, represents promising target supports new strategies improving follicles.

Язык: Английский

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