Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 81 - 81
Опубликована: Янв. 9, 2025
Cyclodextrins
can
serve
as
carriers
for
various
payloads,
utilizing
their
capacity
to
form
unique
host-guest
inclusion
complexes
within
cavity
and
versatile
surface
functionalization.
Recently,
cationic
cyclodextrins
have
gained
considerable
attention,
they
improve
drug
permeability
across
negatively
charged
cell
membranes
efficiently
condense
nucleic
acid
due
electrostatic
interactions.
This
review
focuses
on
state-of-the-art
recent
advances
in
the
construction
of
cyclodextrin-based
delivery
systems.
First,
we
identified
different
moieties
that
are
commonly
employed
design
with
enhanced
complexation
ability.
Subsequently,
a
wide
range
systems
were
analyzed
emphasis
chemistry,
release
profiles,
therapeutic
outcomes.
The
evaluation
platforms
was
also
based
four
major
types
drugs,
such
anticancer,
anti-inflammatory,
antibacterial,
antidiabetic
agents.
acids
summarized
while
focusing
condensation
ability,
transfection
efficiency,
biocompatibility
comparison
commercially
available
vectors
PEI
25
kDa
lipofectamine
2000.
Furthermore,
highlighted
potential
constructing
multimodal
simultaneous
encapsulation
both
drugs
acids.
Finally,
challenges
limitations
associated
cyclodextrin
setups
discussed.
Язык: Английский
Development of Deferoxamine-Functionalized Cyclodextrin Polymer for Targeted Iron Chelation
Опубликована: Янв. 1, 2025
Язык: Английский
A Mini-Review on Enhancing Solubility in Topical Hydrogel Formulations Using Solid Dispersion Technology for Poorly Water-Soluble Drugs
Colloids and Interfaces,
Год журнала:
2025,
Номер
9(2), С. 17 - 17
Опубликована: Март 21, 2025
The
solubility
behavior
of
drugs
is
a
critical
factor
in
formulation
development.
Approximately
40–45%
new
face
market
entry
challenges
due
to
low
water
solubility.
Enhancing
drug
bioavailability
thus
essential
developing
pharmaceutical
dosage
forms.
Many
biopharmaceutical
class
II
and
IV
are
commonly
prescribed
treat
inflammations,
infections,
pain
from
various
pathologies.
Their
oral
administration
has
several
drawbacks,
including
significant
first-pass
liver
effects,
bioavailability,
adverse
gastrointestinal
effects.
Topical
application
gained
relevance
its
advantages
delivering
directly
the
target
site,
avoiding
irritation,
increasing
their
effectiveness.
However,
topical
hydrogel
formulations
with
poorly
water-soluble
related
skin’s
permeability.
Therefore,
preparing
hydrogels
using
solid
dispersions
(SDs)
an
effective
strategy
enhance
dissolution
rate
soluble
drugs,
thereby
improving
bioavailability.
In
this
review,
concepts
SDs,
delivery
systems,
incorporating
as
well
preparation
methods,
characterization,
applications,
will
be
discussed.
Язык: Английский
Development of Deferoxamine‐Functionalized Cyclodextrin Polymer for Targeted Iron Chelation
ChemistryOpen,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Polymeric
systems
are
used
in
clinical
settings
to
bind
small
molecules
and
ions.
They
show
advantages
pharmacokinetics
reduced
side
effects
compared
low‐molecular‐weight
agents.
In
this
study,
a
cross‐linked
β‐cyclodextrin
polymer
is
functionalized
with
deferoxamine
develop
more
efficient
ways
of
delivering
iron
chelators.
Deferoxamine
well‐known
chelator
treat
overload
conditions.
The
resulting
polymeric
conjugate,
an
equal
complexing
capacity
deferoxamine,
showed
significantly
lower
cytotoxicity
free
all
cancer
cell
lines
studied
(neuroblastoma
SHSY5Y,
breast
MDA‐MB‐231,
ovarian
adenocarcinoma
A2780,
lung
A549).
results
demonstrate
that
the
conjugation
reduces
toxicity
at
same
reveals
potential
deferoxamine‐based
cyclodextrin
conjugates
as
novel
approach
for
targeting
dyshomeostasis.
Язык: Английский