Lung structural cell dynamics are altered by influenza virus infection experience leading to rapid immune protection following viral re-challenge DOI Creative Commons
Julie C. Worrell, Kerrie E Hargrave, George Finney

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

Abstract Lung structural cells, including epithelial cells and fibroblasts, form barriers against pathogens trigger immune responses following infections such as influenza A virus. This response leads to the recruitment of innate adaptive required for viral clearance. Some these recruited remain within lung infection contribute enhanced control subsequent infections. There is growing evidence that can also display long-term changes or insults. Here we investigate mouse endothelial virus find all three cell types maintain an imprint infection, particularly in genes associated with communication T cells. from IAV-infected mice functional by more rapidly controlling than naïve animals. rapid anti-viral increased expression molecules communicate demonstrates sustained functions infection. These data suggest could be effective targets vaccines boost durable protective immunity. Graphical Highlights blood inflammatory (IAV) at least 40 days post-infection. In vivo re-infection a spatially restricted compared primary are not early after Ex IAV animals absence

Язык: Английский

Lung structural cell dynamics are altered by influenza virus infection experience leading to rapid immune protection following viral re-challenge DOI Creative Commons
Julie C. Worrell, Kerrie E Hargrave, George Finney

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

Abstract Lung structural cells, including epithelial cells and fibroblasts, form barriers against pathogens trigger immune responses following infections such as influenza A virus. This response leads to the recruitment of innate adaptive required for viral clearance. Some these recruited remain within lung infection contribute enhanced control subsequent infections. There is growing evidence that can also display long-term changes or insults. Here we investigate mouse endothelial virus find all three cell types maintain an imprint infection, particularly in genes associated with communication T cells. from IAV-infected mice functional by more rapidly controlling than naïve animals. rapid anti-viral increased expression molecules communicate demonstrates sustained functions infection. These data suggest could be effective targets vaccines boost durable protective immunity. Graphical Highlights blood inflammatory (IAV) at least 40 days post-infection. In vivo re-infection a spatially restricted compared primary are not early after Ex IAV animals absence

Язык: Английский

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