Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
95, С. 105564 - 105564
Опубликована: Март 12, 2024
The
nasal
route
has
routinely
been
used
in
the
local
delivery
of
drugs,
however
with
innovations
nanotechnology,
there
increased
interest
exploring
this
more
for
systemic,
and
brain/CNS
delivery.
This
is
because
safe,
non-invasive,
medications
can
be
self-administered
to
achieve
rapid
therapeutic
drug
levels
minimal
doses.
Polymeric
nanoparticles
(NPs)
such
as
PLGA
NPs
have
a
wide
range
applications
delivery,
due
their
large
surface
area
modification
targeting
ligands
polymers
which
enhances
cellular
uptake,
bioavailability
at
target
sites.
review
covers
recent
research
on
use
small
molecule
drugs
macromolecules
via
route.
It
some
background
information
about
challenges
delivering
most
common
polymer
coatings
are
highlighted.
Finally,
patents
clinical
trials
also
covered.
Molecules,
Год журнала:
2024,
Номер
29(17), С. 3994 - 3994
Опубликована: Авг. 23, 2024
Drug
resistance
remains
a
critical
barrier
in
cancer
therapy,
diminishing
the
effectiveness
of
chemotherapeutic,
targeted,
and
immunotherapeutic
agents.
Overexpression
proteins
such
as
B-cell
lymphoma
2
(Bcl-2),
inhibitor
apoptosis
(IAPs),
protein
kinase
B
(Akt),
P-glycoprotein
(P-gp)
various
cancers
leads
to
by
inhibiting
apoptosis,
enhancing
cell
survival,
expelling
drugs.
Although
several
inhibitors
targeting
these
have
been
developed,
their
clinical
use
is
often
hampered
systemic
toxicity,
poor
bioavailability,
development.
Nanoparticle-based
drug
delivery
systems
present
promising
solution
improving
solubility,
stability,
targeted
delivery.
These
leverage
Enhanced
Permeation
Retention
(EPR)
effect
accumulate
tumor
tissues,
reducing
off-target
toxicity
increasing
therapeutic
efficacy.
Co-encapsulation
strategies
involving
anticancer
drugs
within
nanoparticles
shown
potential
achieving
coordinated
pharmacokinetic
pharmacodynamic
profiles.
This
review
discusses
mechanisms
resistance,
limitations
current
inhibitors,
advantages
nanoparticle
overcoming
challenges.
By
advancing
technologies,
we
can
enhance
treatment
outcomes
move
towards
more
effective
therapies.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117327 - 117327
Опубликована: Авг. 30, 2024
Breast
cancer
(BC)
is
one
of
the
most
frequently
diagnosed
cancers
in
women.
Chemotherapy
continues
to
be
treatment
choice
for
clinically
combating
it.
Nevertheless,
chemotherapy
process
hindered
by
multidrug
resistance,
thereby
impacting
effectiveness
treatment.
Multidrug
resistance
(MDR)
refers
phenomenon
which
malignant
tumour
cells
develop
anticancer
drugs
after
single
exposure.
It
can
occur
with
a
broad
range
chemotherapeutic
distinct
chemical
structures
and
mechanisms
action,
it
major
causes
failure
disease
relapse.
Research
has
long
been
focused
on
overcoming
MDR
using
multiple
drug
combinations,
but
this
approach
often
associated
serious
side
effects.
Therefore,
there
pressing
need
in-depth
research
into
MDR,
as
well
development
new
reverse
improve
efficacy
breast
chemotherapy.
This
article
reviews
explores
application
nano-drug
delivery
system
(NDDS)
overcome
cancer.
The
aim
offer
valuable
reference
further
endeavours.
Drug Resistance Updates,
Год журнала:
2024,
Номер
77, С. 101140 - 101140
Опубликована: Авг. 16, 2024
Membrane
protein-mediated
resistance
is
a
multidisciplinary
challenge
that
spans
fields
such
as
medicine,
agriculture,
and
environmental
science.
Understanding
its
complexity
devising
innovative
strategies
are
crucial
for
treating
diseases
like
cancer
managing
resistant
pests
in
agriculture.
This
paper
explores
the
dual
nature
of
mechanisms
across
different
organisms:
On
one
hand,
animals,
bacteria,
fungi,
plants,
insects
exhibit
convergent
evolution,
leading
to
development
similar
mechanisms.
other
influenced
by
diverse
pressures
structural
differences
among
organisms,
they
also
demonstrate
divergent
characteristics.
prevalent
insects,
reflecting
their
shared
survival
evolved
through
evolution
address
challenges.
However,
variations
ecological
environments
biological
characteristics
result
differing
responses
resistance.
Therefore,
examining
these
not
only
enhances
our
understanding
adaptive
but
provides
theoretical
support
insights
addressing
drug
advancing
pharmaceutical
development.
Pharmacological Research,
Год журнала:
2023,
Номер
190, С. 106732 - 106732
Опубликована: Март 15, 2023
High
mobility
group
A
2
(HMGA2)
is
a
protein
that
modulates
the
structure
of
chromatin
in
nucleus.
Importantly,
aberrant
expression
HMGA2
occurs
during
carcinogenesis,
and
this
an
upstream
mediator
cancer
hallmarks
including
evasion
apoptosis,
proliferation,
invasion,
metastasis,
therapy
resistance.
targets
critical
signaling
pathways
such
as
Wnt/β-catenin
mTOR
cells.
Therefore,
suppression
function
notably
decreases
progression
improves
outcome
patients.
As
mainly
oncogenic,
targeting
by
non-coding
RNAs
(ncRNAs)
crucial
to
take
into
consideration
since
it
affects
function.
MicroRNAs
(miRNAs)
belong
ncRNAs
are
master
regulators
vital
cell
processes,
which
affect
all
aspects
hallmarks.
Long
(lncRNAs)
circular
(circRNAs),
other
members
ncRNAs,
mediators
miRNAs.
The
current
review
intends
discuss
importance
miRNA/HMGA2
axis
modulation
various
types
cancer,
mentions
lncRNAs
circRNAs,
regulate
mediators.
Finally,
we
effect
miRNAs
interactions
on
response
cells
therapy.
Regarding
role
regulation
cells,
considering
confirmed
interaction
between
one
miRNAs,
promising
could
be
subject
future
clinical
trial
experiments.
Pharmaceutics,
Год журнала:
2023,
Номер
15(8), С. 2045 - 2045
Опубликована: Июль 29, 2023
Plant
and
herbal
essential
oils
(EOs)
offer
a
wide
range
of
pharmacological
actions
that
include
anticancer
effects.
Here,
we
evaluated
the
cytotoxic
activity
EO
from
Lippia
alba
(chemotype
linalool),
L.
dihydrocarvone,
LaDEO),
Clinopodium
nepeta
(L.)
Kuntze
(CnEO),
Eucalyptus
globulus,
Origanum
×
paniculatum,
Mentha
piperita,
arvensis
L.,
Rosmarinus
officinalis
against
human
lung
(A549)
colon
(HCT-116)
cancer
cells.
The
cells
were
treated
with
increasing
concentrations
(0-500
µL/L)
for
24
h,
was
assessed.
LaDEO
CnEO
most
potent
EOs
(IC50
range,
145-275
µL/L).
gas
chromatography-mass
spectrometry
method
used
to
determine
their
composition.
Considering
limitations
as
therapeutic
agents
(poor
water
solubility,
volatilization,
oxidation),
whether
encapsulation
into
solid
lipid
nanoparticles
(SLN/EO)
enhanced
activity.
Highly
stable
spherical
SLN/LaDEO
SLN/CnEO
SLN/EO
obtained,
mean
diameter
140-150
nm,
narrow
size
dispersion,
Z
potential
around
-5mV.
strongly
increased
activity,
particularly
in
A549
exposed
=
66
µL/L
CnEO).
physicochemical
characterization,
biosafety,
mechanisms
also
containing
97
±
1%
highly
up
6
months.
An
vitro
release
SLN
at
an
acidic
pH
(endolysosomal
compartment)
observed.
proved
be
safe
blood
components
non-toxic
normal
WI-38
concentrations.
substantially
cell
death
migration
inhibition
compared
free
CnEO.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Июнь 22, 2023
Colorectal
cancer
(CRC)
is
a
prevalent
malignancy
that
affects
large
percentage
of
the
global
population.
The
conventional
treatments
for
CRC
have
number
limitations.
Nanoparticles
emerged
as
promising
treatment
method
due
to
their
ability
directly
target
cells
and
regulate
drug
release,
thereby
enhancing
therapeutic
efficacy
minimizing
side
effects.
This
compilation
examines
use
nanoparticles
delivery
systems
treatment.
Different
nanomaterials
can
be
used
administer
anticancer
drugs,
including
polymeric
nanoparticles,
gold
liposomes,
solid
lipid
nanoparticles.
In
addition,
we
discuss
recent
developments
in
nanoparticle
preparation
techniques,
such
solvent
evaporation,
salting-out,
ion
gelation,
nanoprecipitation.
These
methods
demonstrated
high
penetrating
epithelial
cells,
prerequisite
effective
delivery.
article
focuses
on
various
targeting
mechanisms
utilized
by
CRC-targeted
advancements
this
field.
review
offers
descriptive
information
regarding
numerous
nano-preparative
procedures
colorectal
treatments.
We
also
outlook
innovative
techniques
management
CRC,
potential
application
targeted
concludes
with
discussion
current
nanotechnology
patents
clinical
studies
diagnose
CRC.
results
investigation
suggest
great
cancer.
Separations,
Год журнала:
2024,
Номер
11(2), С. 61 - 61
Опубликована: Фев. 17, 2024
In
this
study,
we
biosynthesized
the
stable
silver
nanoparticles
(AgNPs)
from
Momordica
cymbalaria
leaves
to
evaluate
their
antioxidant,
antibacterial,
cytotoxic,
and
photocatalytic
properties.
Initially,
screened
bioactive
compounds
M.
extract
using
GC-MS.
The
biosynthesis
of
Mc-AgNPs
was
confirmed
instruments,
such
as
UV-visible
spectroscopy
FT-IR,
XRD,
SEM
with
EDX,
HR-TEM
analyses.
spectrum
indicated
absorbance
at
425
nm.
crystallite
size
cymbalaria-stabilized
determined
be
20.14
morphology
synthesized
were
via
SEM-EDX
analyses,
a
range
16
22
exhibited
yield
60%.
demonstrated
strong
antioxidant
properties
prominent
antibacterial
activity
against
human
pathogenic
bacteria.
cytotoxicity
study
revealed
that
effective
MCF-7
cells
in
dose-dependent
manner.
recognized
bioactivities
confirm
act
catalysts
oxidation
serve
potent
anticancer,
agents.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Апрель 15, 2024
Abstract
Mitochondrial
permeability
transition
(mPT)-mediated
mitochondrial
dysfunction
plays
a
pivotal
role
in
various
human
diseases.
However,
the
intricate
details
of
its
mechanisms
and
sequence
events
remain
elusive,
primarily
due
to
interference
caused
by
Bax/Bak-induced
outer
membrane
permeabilization
(MOMP).
To
address
these,
we
have
developed
methodology
that
utilizes
nano-flow
cytometry
(nFCM)
quantitatively
analyze
opening
pore
(mPTP),
dissipation
potential
(
$$\Delta$$
Δ
Ψ
m
),
release
cytochrome
c
(Cyt
c),
other
molecular
alternations
isolated
mitochondria
response
mPT
induction
at
single-mitochondrion
level.
It
was
identified
betulinic
acid
(BetA)
antimycin
A
can
directly
induce
through
mPT-mediated
mechanisms,
while
cisplatin
staurosporine
cannot.
In
addition,
nFCM
analysis
also
revealed
BetA
induces
mPTP
reduction
Bcl-2
Bcl-xL
protein
levels,
along
with
an
elevation
ROS
content.
Employing
dose
time-dependent
strategies
BetA,
for
first
time,
experimentally
verified
sequential
occurrence
depolarization
prior
Cyt
during
dysfunction.
Notably,
our
study
uncovers
simultaneous
cell-death-associated
factors,
including
c,
AIF,
PNPT1,
mtDNA
mPT,
implying
initiation
multiple
cell
death
pathways.
Intriguingly,
caspase-independent
death,
even
absence
Bax/Bak,
thereby
overcoming
drug
resistance.
The
presented
findings
offer
new
insights
into
using
nFCM,
emphasizing
targeting
such
innovative
cancer
therapies
interventions.
