Protective Effect of Fisetin on Subacute and Chronic Arsenic and Fluoride Co‐Exposure Induced Hepatic, Renal and Cardiac Toxicities in Mice
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(2)
Опубликована: Янв. 26, 2025
ABSTRACT
Arsenic
and
fluoride
are
potent
toxicants
frequently
present
in
drinking
water
food,
posing
severe
health
risks
through
toxic
impacts
on
key
organs,
primarily
by
inducing
oxidative
stress.
Combined
exposure
to
these
elements
exacerbates
damage,
yet
effective
strategies
for
preventing
managing
their
toxicities
remain
elusive.
Fisetin,
a
bioflavonoid
known
its
antioxidant
anti‐inflammatory
properties,
has
demonstrated
protective
effects
multiple
toxicity
studies.
However,
effect
arsenic‐
fluoride‐induced
vital
organs
(particularly
the
liver,
kidneys,
heart)
remains
unexplored.
This
study
investigates
potential
of
fisetin
against
subacute
chronic
co‐exposure
arsenic
organ
murine
model.
Male
mice
were
administered
water,
while
(5,
10,
20
mg/kg/day,
orally)
was
co‐administered
simultaneously.
Animals
sacrificed
at
4
weeks
(subacute)
24
(chronic)
kidney,
heart
tissue
analysis,
assessing
biochemical
markers
accumulation.
Spectrophotometry
revealed
some
degree
chelation
with
fisetin.
The
results
In
Vivo
studies
showed
that
both
led
significant
increases
pro‐oxidant
levels
(ROS,
TBARS,
nitrite)
accumulation,
along
reduced
GSH
content
compared
control.
Fisetin
treatment
dose‐dependently
stress
exposed
animals.
findings
highlight
fisetin's
activity
capacity
reduce
burden
as
mechanisms.
These
support
or
fisetin‐rich
fruit
consumption
therapeutic
strategy
mitigate
from
co‐exposure.
Язык: Английский
Development of eugenol fortified fisetin loaded nano-invasomes gel
Xenobiotica,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Март 13, 2025
1.
The
goal
of
current
investigation
was
to
develop
eugenol
fortified
fisetin
nano-invasomes.
Fisetin
loaded
invasomes
were
prepared
using
thin
film
hydration
procedure
and
evaluated
for
various
parameters.
Additionally,
the
optimized
formulation
(F5)
converted
gel
Carbopol®
as
gelling
agent
pH,
spreadability,
homogeneity,
drug
content,
in
vitro
release,
antioxidant
activity
stability
study.2.
Prepared
demonstrated
vesicles
size,
PDI,
zeta
potential
entrapment
efficiency
153.85
±
14.32
nm,
0.208
0.042,
-12.67
1.08
mV
72.10
6.36%.
TEM
image
indicated
that
are
intact,
spherical
found
range
nanosized
scale.
showed
better
spreadability
released
contrast
control
gel.
Substantial
improvement
DPPH
radical
scavenging
44.70%
(3.1
µM)
83.94%
(50
µM),
noted
compared
at
39.47%
79.10%
µM).
stable
4
°C.3.
Based
on
results,
a
viable
method
delivery
bioactive
compound(s)
including
fisetin.
Язык: Английский
Enhanced cognitive function in mice through intranasal delivery of sinapic acid via chitosan-coated solid lipid nanoparticles
A Prabakaran,
Debarati Rakshit,
Inklisan Patel
и другие.
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
675, С. 125565 - 125565
Опубликована: Апрель 1, 2025
Язык: Английский
Bio‐Nano Innovations Targeting the Neurovascular Complex for Epilepsy Treatment
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Abstract
Epilepsy
is
a
prevalent
chronic
neurological
disorder
characterized
by
seizures
resulting
from
an
imbalance
between
excitatory
and
inhibitory
neurons.
While
pharmacotherapy
remains
the
standard
treatment,
traditional
faces
significant
challenges,
including
poor
brain
penetration,
high
drug
resistance
rates,
providing
only
symptomatic
relief,
rather
than
addressing
underlying
causes
for
comprehensive
cure.
Recently,
neurovascular
complex
(NVC)
has
gained
attention
its
critical
role
in
development
progression
of
epilepsy.
Simultaneously,
various
innovative
bio‐nanotechnology
systems
have
emerged,
specifically
designed
to
enhance
delivery
across
enable
precise
targeting
within
lesion.
Herein,
this
review
begins
outlining
core
NVC
involved
epilepsy
breaking
it
down
into
four
key
components:
blood‐brain
barrier
(BBB),
neurons,
glial
cells,
microenvironment.
The
viability
improve
therapy
analyzed.
Next,
systems,
detailing
their
design
principles,
construction
strategies,
preclinical
evaluations
are
highlighted.
Finally,
prospects
next‐generation
nanotechnologies
challenges
that
must
be
overcome
effective
clinical
translation
discussed.
Overall,
aims
guide
more
efficient
bio‐nano
therapies,
ultimately
enhancing
treatment
outcomes
patients.
Язык: Английский
Nanoformulated fisetin ameliorates Alzheimer's disease via reducing proinflammatory cytokines and activating the NRF2/HO-1 pathway
Nanomedicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Ноя. 18, 2024
The
study
aimed
to
evaluate
the
neuroprotective
effect
of
a
chitosan-coated
fisetin
nanoformulation
in
an
experimental
Alzheimer's
disease
(AD)
model,
focusing
on
improving
fisetin's
pharmacokinetics
and
exploring
its
impact
both
brain
colon
pathology.
Язык: Английский
Impact of Oxidative Stress and Neuroinflammation on Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Downregulation and Endoplasmic Reticulum Stress in Temporal Lobe Epilepsy
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
8(1), С. 173 - 188
Опубликована: Дек. 16, 2024
Epilepsy
is
one
of
the
most
common
neurological
disorders.
Calcium
dysregulation
and
neuroinflammation
are
essential
mechanisms
in
epileptogenesis.
Sarco/endoplasmic
reticulum
(ER)
Ca2+-ATPase
2b
(SERCA2b),
a
crucial
calcium
regulatory
pump,
plays
pathological
roles
various
dysregulation-related
diseases.
However,
link
between
SERCA2b
epilepsy
remains
undetermined.
This
study
aimed
to
establish
relationship
SERCA2b,
oxidative
stress,
elucidate
underlying
molecular
mechanism
Neuroinflammation
stress
were
induced
N2a
cells
using
lipopolysaccharide
(LPS)
hydrogen
peroxide
(H2O2).
experimental
temporal
lobe
(TLE)
was
mice
pilocarpine.
Further,
effects
on
ER
markers
assessed
at
protein
mRNA
levels.
imaging
employed
determine
intracellular
expression
significantly
decreased
after
LPS,
H2O2,
pilocarpine
exposure
both
levels,
mediated
by
upregulating
neuroinflammation.
downregulation
associated
with
increased
production
reactive
oxygen
species
elevated
leading
markers.
Our
findings
highlight
TLE.
The
results
suggest
that
targeting
could
restore
homeostasis
processes,
potentially
providing
therapeutic
option
for
underscores
importance
pathophysiology
its
potential
as
target.
Язык: Английский