Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing

Bioactive Materials, Год журнала: 2023, Номер 30, С. 129 - 141

Опубликована: Июль 28, 2023

In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. this study, series adhesive conductive antibacterial hydrogel based on oxidized sodium alginate-grafted dopamine/carboxymethyl chitosan/Fe3+ (OSD/CMC/Fe hydrogel)/polydopamine-encapsulated poly(thiophene-3-acetic acid) (OSD/CMC/Fe/PA hydrogel) were prepared for the repair infected wound. The Schiff base and Fe3+ coordination bonds structure are dynamic can be repaired automatically after network disrupted. Macroscopically, exhibits properties, allowing dressing adapt complex surfaces. OSD/CMC/Fe/PA showed conductivity photothermal properties under near-infrared (NIR) light irradiation. addition, hydrogels exhibit tunable rheological suitable mechanical antioxidant tissue adhesion hemostatic Furthermore, all improved healing in full-thickness defect skin test mice. size by OSD/CMC/Fe/PA3 + NIR was much smaller (12%) than control group treated Tegaderm™ film 14 days. conclusion, have high efficiency, conductivity, great biocompatibility, hemostasis making them promising candidates treatment wounds.

Язык: Английский

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Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100582 - 100582

Опубликована: Фев. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Язык: Английский

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Self-adhesive, self-healing, biocompatible and conductive polyacrylamide nanocomposite hydrogels for reliable strain and pressure sensors

Nano Energy, Год журнала: 2023, Номер 109, С. 108324 - 108324

Опубликована: Март 2, 2023

Язык: Английский

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Stretchable, Adhesive, Self-Healable, and Conductive Hydrogel-Based Deformable Triboelectric Nanogenerator for Energy Harvesting and Human Motion Sensing

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(7), С. 9126 - 9137

Опубликована: Фев. 14, 2022

Hydrogels that combine the integrated attributes of being adhesive, self-healable, deformable, and conductive show great promise for next-generation soft robotic/energy/electronic applications. Herein, we reported a dual-network polyacrylamide (PAAM)/poly(acrylic acid) (PAA)/graphene (GR)/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) (MAGP) hydrogel composed dual-cross-linked PAAM PAA as well PEDOT:PSS GR conducting component combines these features. A wearable strain sensor is fabricated by sandwiching MAGP hydrogels between two dielectric carbon nanotubes (CNTs)/poly(dimethylsiloxane) (PDMS) layers, which can be utilized to monitor delicate vigorous human motion. In addition, hydrogel-based act deformable triboelectric nanogenerator (D-TENG) harvesting mechanical energy. The D-TENG demonstrates peak output voltage current 141 V 0.8 μA, respectively. could easily light 52 yellow-light-emitting diodes (LEDs) simultaneously demonstrated capability power small electronics, such hygrometer thermometer. This work provides potential approach development energy sources self-powered sensors.

Язык: Английский

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Highly sensitive strain sensor and self-powered triboelectric nanogenerator using a fully physical crosslinked double-network conductive hydrogel

Nano Energy, Год журнала: 2022, Номер 104, С. 107955 - 107955

Опубликована: Ноя. 1, 2022

Язык: Английский

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Mechanically Robust and Transparent Organohydrogel‐Based E‐Skin Nanoengineered from Natural Skin

Advanced Functional Materials, Год журнала: 2023, Номер 33(15)

Опубликована: Янв. 29, 2023

Abstract Electronic skins (e‐skins), which are mechanically compliant with human skin, regarded as ideal electronic devices for noninvasive human–machine interaction and wearable devices. In order to fully mimic e‐skins should possess reliable mechanical properties be able resist external environmental factors like heat, cold, desiccation, bacteria, while perceiving multiple stimuli, such temperature, humidity, strain. Here, a transparent, robust, environmentally stable, versatile natural skin‐derived organohydrogel (NSD‐Gel) is nanoengineered through the integration of betaine, silver nanoparticles, sodium chloride in glycerol/water binary solvent. The transparent NSD‐Gel e‐skin exhibits outstanding tensile strength (7.33 MPa), puncture resistance, moisture retention, self‐regeneration, antibacterial properties. Additionally, possesses enhanced cold/heat resistance stimuli‐responsive characteristics that effectively sense temperature humidity changes, well physiological body motion signals. vitro vivo experiments show confers desired biocompatibility tissue protective even extremely harsh environments (−196 °C 100 °C). has great potential applications multidimensional devices, human‐machine interfaces, artificial intelligence, generating platform development high‐performance on‐demand

Язык: Английский

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Bioinspired Self‐healing Soft Electronics

Advanced Functional Materials, Год журнала: 2023, Номер 33(17)

Опубликована: Фев. 7, 2023

Abstract Inspired by nature, various self‐healing materials that can recover their physical properties after external damage have been developed. Recently, widely used in electronic devices for improving durability and protecting the from failure during operation. Moreover, integrate many other intriguing of biological systems, such as stretchability, mechanical toughness, adhesion, structural coloration, providing additional fascinating experiences. All these inspirations attracted extensive research on bioinspired soft electronics. This review presents a detailed discussion Firstly, two main healing mechanisms are introduced. Then, four categories electronics, including insulators, semiconductors, conductors, ionic reviewed, functions, working principles, applications summarized. Finally, human‐inspired animal‐inspired well applications, organic field‐effect transistors (OFETs), pressure sensors, strain chemical triboelectric nanogenerators (TENGs), actuators, cutting‐edge promising field is believed to stimulate more excellent cross‐discipline works material science, flexible novel accelerating development human motion monitoring, environmental sensing, information transmission, etc.

Язык: Английский

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Self‐Healing Hydrogel Bioelectronics

Advanced Materials, Год журнала: 2023, Номер 36(21)

Опубликована: Ноя. 22, 2023

Abstract Hydrogels have emerged as powerful building blocks to develop various soft bioelectronics because of their tissue‐like mechanical properties, superior bio‐compatibility, the ability conduct both electrons and ions, multiple stimuli‐responsiveness. However, hydrogels are vulnerable damage, which limits usage in developing durable hydrogel‐based bioelectronics. Self‐healing aim endow with property repairing specific functions after failure, thus improving durability, reliability, longevity. This review discusses recent advances self‐healing hydrogels, from mechanisms, material chemistry, strategies for properties improvement hydrogel materials, design, fabrication, applications bioelectronics, including wearable physical biochemical sensors, supercapacitors, flexible display devices, triboelectric nanogenerators (TENGs), implantable etc. Furthermore, persisting challenges hampering development prospects proposed. is expected expedite research

Язык: Английский

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Highly conductive and tough polyacrylamide/sodium alginate hydrogel with uniformly distributed polypyrrole nanospheres for wearable strain sensors

Carbohydrate Polymers, Год журнала: 2023, Номер 315, С. 120953 - 120953

Опубликована: Апрель 28, 2023

Язык: Английский

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Self-Healing Hydrogels: From Synthesis to Multiple Applications

ACS Materials Letters, Год журнала: 2023, Номер 5(7), С. 1787 - 1830

Опубликована: Май 26, 2023

Due to the good reliability and long-term stability, self-healing hydrogels have emerged as promising soft materials for tissue engineering, smart wearable sensors, bioelectronics, energy storage devices. The mechanism depends on reversible chemical or physical cross-linking interactions. Self-healing with fascinating features (including mechanical performances, biocompatibility, conductivity, antibacterial ability, responsiveness, etc.) are being designed developed according practical application requirements. In this review, recent progress in their synthesis strategies multiple applications is summarized. Their involve processes a combination of two. include flexible strain supercapacitors, actuators, adhesives, wound healing, drug delivery, tumor treatment, 3D printing, etc. Finally, current challenges, future development, opportunities discussed.

Язык: Английский

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