Recent advances of piezoelectric materials used in sonodynamic therapy of tumor
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
523, С. 216282 - 216282
Опубликована: Окт. 22, 2024
Язык: Английский
Single‐Atom W Anchored Hexagonal Boron Nitride Piezoelectric Nanosonosensitizer Remodels Tumor Microenvironment for Enhanced Sonodynamic Therapy
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Sonodynamic
therapy
(SDT)
is
a
non‐invasive,
non‐toxic
technique
that
shows
strong
potential
for
tumor
treatment:
however,
its
application
limited
by
lack
of
efficient
sonosensitizers,
insufficient
oxygen
supply,
and
high
levels
glutathione
(GSH)
in
tumors.
In
this
study,
nanosonosensitizer,
single‐atom
W
anchored
hexagonal
boron
nitride@ferrihydrite@trisulfide
bond‐modified
carboxymethyl
chitosan
(W‐BN@Fht@TSCM)
nanocomplex,
developed
exhibits
an
sonosensitizing
effect
microenvironment
remodeling
ability,
thereby
enhancing
SDT.
W‐BN
prepared
anchoring
monatomic
onto
the
surface
nitride
(h‐BN)
nanosheets,
which
exhibit
superior
piezoelectric
response
to
h‐BN
owing
breaking
lattice
symmetry.
This
excellent
facilitates
production
more
reactive
species
under
ultrasound
conditions.
Moreover,
H
2
O
decomposed
Fht
nanoparticles,
serve
as
catalase‐like
nanoenzymes,
alleviating
hypoxia
providing
sufficient
substrates.
Additionally,
TSCM,
provides
three
unique
redox
sites
potential,
rapidly
efficiently
consumes
GSH,
weakens
antioxidant
defense
mechanism
cells
enhances
efficacy
Improving
material
while
demonstrates
therapeutic
effects
reference
design
SDT
nanosystems.
Язык: Английский
Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy
Inorganics,
Год журнала:
2025,
Номер
13(3), С. 71 - 71
Опубликована: Фев. 26, 2025
As
a
non-invasive
modality,
sonodynamic
therapy
(SDT)
offers
several
advantages
in
cancer
treatment,
including
deep
tissue
penetration
and
precise
spatiotemporal
control,
resulting
from
the
interplay
between
low-intensity
ultrasound
sonosensitizers.
Piezoelectric
materials,
known
for
their
remarkable
capacity
of
interconversion
mechanical
electrical
energy,
have
garnered
considerable
attention
biomedical
applications,
which
can
serve
as
pivotal
sonosensitizers
SDT.
These
materials
generate
internal
electric
fields
via
ultrasound-induced
deformation,
modulates
alteration
charge
carriers,
thereby
initiating
surface
redox
reactions
to
reactive
oxygen
species
(ROS)
realizing
therapeutic
efficacy
This
review
provides
an
in-depth
exploration
piezoelectric
utilized
SDT,
with
particular
emphasis
on
recent
innovations,
elucidation
underlying
mechanisms,
optimization
strategies
advanced
materials.
Furthermore,
incorporation
immunotherapy,
photodynamic,
chemodynamic,
chemotherapy
is
explored,
emphasizing
potential
enhance
outcomes.
By
examining
basic
principles
effect
its
contributions
this
sheds
light
promising
applications
oncology.
It
also
highlights
future
directions
improving
these
expanding
clinical
utility
tumor
therapy.
Язык: Английский
Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(4), С. 114 - 114
Опубликована: Март 24, 2025
Cancer
significantly
impacts
human
quality
of
life
and
expectancy,
with
an
estimated
20
million
new
cases
10
cancer-related
deaths
worldwide
every
year.
Standard
treatments
including
chemotherapy,
radiotherapy,
surgical
removal,
for
aggressive
cancers,
such
as
glioblastoma,
are
often
ineffective
in
late
stages.
Glioblastoma,
example,
is
known
its
poor
prognosis
post-diagnosis,
a
median
survival
time
approximately
15
months.
Novel
therapies
using
local
electric
fields
have
shown
anti-tumour
effects
glioblastoma
by
disrupting
mitotic
spindle
assembly
inhibiting
cell
growth.
However,
constant
application
poses
risks
like
patient
burns.
Wireless
stimulation
via
piezoelectric
nanomaterials
offers
safer
alternative,
requiring
ultrasound
activation
to
induce
therapeutic
effects,
altering
voltage-gated
ion
channel
conductance
depolarising
membrane
potentials.
This
review
highlights
the
mechanism,
drug
delivery,
activation,
current
technologies
cancer
therapy,
emphasising
need
further
research
address
limitations
biocompatibility
whole
systems.
The
goal
underscore
these
areas
inspire
avenues
overcome
barriers
developing
nanoparticle-based
therapies.
Язык: Английский
Advances and Perspectives on Bioelectronic and Atomic Nanogenerators for Anticancer Therapy
Nanoenergy Advances,
Год журнала:
2025,
Номер
5(2), С. 4 - 4
Опубликована: Март 31, 2025
Nowadays,
due
to
improvements
in
living
standards,
more
attention
is
reserved
all-around
disease
prevention
and
health
care.
In
particular,
research
efforts
have
been
made
for
developing
novel
methods
treatments
anti-cancer
therapy.
Self-powered
nanogenerators
emerged
recent
years
as
an
attractive
cost-effective
technology
harvest
energy
or
biosensing
applications.
Bioelectronic
can
be
used
inducing
tissue
recovery
treating
human
illness
through
electrical
stimulation.
However,
there
still
a
lack
of
comprehensive
cognitive
assessment
these
devices
platforms,
especially
regarding
which
requirements
must
satisfied
working
principles
transduction
adopted
effectively
the
body.
This
review
covers
most
advances
bioelectronic
therapy,
based
on
different
transducing
strategies
(photodynamic
drug
delivery,
stimulation,
atomic
nanogenerators,
etc.),
potential
mechanisms
repair
promotion
are
discussed.
The
prospective
challenges
finally
summarized
with
indication
future
outlook.
Язык: Английский
Revealing the Optimization Route of Piezoelectric Sonosensitizers: From Mechanism to Engineering Methods
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 7, 2024
Piezoelectric
catalysis
is
a
novel
catalytic
technology
that
has
developed
rapidly
in
recent
years
and
attracted
extensive
interest
among
researchers
the
field
of
tumor
therapy
for
its
acoustic-sensitizing
properties.
Nevertheless,
are
still
controversial
about
key
technical
difficulties
modulation
piezoelectric
sonosensitizers
applications,
which
undoubtedly
major
obstacle
to
performance
sonosensitizers.
Clarification
this
challenge
will
be
beneficial
design
optimization
future.
Here,
authors
start
from
mechanism
elaborate
methods
defect
engineering
phase
based
on
energy
band
theory.
The
combined
therapeutic
strategy
with
enzyme
immunotherapy
introduced.
Finally,
challenges
prospects
highlighted.
Hopefully,
explorations
can
guide
toward
applied
their
own
research.
Язык: Английский
Insights into the Engineered Gold Nanoparticle-Based Remedy for Supplementation Therapy of Ovarian Carcinoma
ACS Omega,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 16, 2024
Chronic
diseases,
notably
cancer,
pose
a
significant
global
threat
to
human
life.
Oncologists
and
medical
professionals
addressing
malignancies
confront
challenges
such
as
toxicity
multidrug
resistance.
To
tackle
these
issues,
the
focus
has
shifted
toward
employment
of
multifunctional
colloidal
gold
nanoparticles.
This
study
aims
design
pH-sensitive
doxorubicin-loaded
nanoparticles
using
polyvinylpyrrolidone.
The
cytotoxic
efficacy
designed
nanoarchitecture
its
doxorubicin
counterpart
was
assessed
in
an
vitro
model
HeLa
cell.
In
comparison
free
drug,
experimental
evaluations
showed
that
outperformed
significantly
lower
unspecific
drug
leaching
efficiently
delivered
payload
controlled
manner,
boosting
chemotherapy
outcomes.
work
opens
streamlined
approach
for
engineering
could
be
further
expanded
incorporate
other
therapeutics
and/or
functional
moieties
require
optimized
delivery,
offering
one-size-fits-all
solution
paving
revolutionary
adjustments
healthcare
procedures.
Язык: Английский