Nanoenergy Advances,
Год журнала:
2024,
Номер
4(4), С. 300 - 317
Опубликована: Окт. 9, 2024
Nanofibers
can
be
produced
by
various
techniques,
such
as
a
broad
range
of
electrospinning
techniques
to
produce
nanofiber
mats
from
different
polymers
or
polymer
blends,
often
filled
with
metallic
semiconducting
nanoparticles
nanotechnological
bottom-up
top-down
methods.
They
are
important
parts
wide
variety
energy
applications,
batteries,
fuel
cells,
photovoltaics,
hydrogen
storage
materials.
Usually,
their
physical
chemical
parameters
measured
averaging
over
fiber
bundle
part
mat.
Here,
we
report
the
possibility
measuring
and
properties
single
nanofibers
nanowires.
Such
measurements
more
complicated
than
investigations
bundles
whole
and,
thus,
less
found
in
literature.
After
fast
increase
between
2001
2009,
numbers
respective
studies
now
stagnating.
This
review
thus
aims
make
possibilities
visible
broader
scientific
audience
providing
several
examples
based
on
atomic
force
microscopy
(AFM)
other
broadly
available
techniques.
The
focus
this
is
technologies
that
reveal
information
pure
surface
morphology
nanowires,
mechanical
wettability,
porosity,
electrical
conductivity.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
The
shapes
of
micro‐
and
nano‐products
have
profound
influences
on
their
functional
performances,
which
has
not
received
sufficient
attention
during
the
past
several
decades.
Electrohydrodynamic
atomization
(EHDA)
techniques,
mainly
include
electrospinning
electrospraying,
are
facile
in
manipulate
products'
shapes.
In
this
review,
generated
using
EHDA
for
modifying
drug
release
profiles
reviewed.
These
linear
nanofibers,
round
micro‐/nano‐particles,
beads‐on‐a‐string
hybrids.
They
can
be
further
divided
into
different
kinds
sub‐shapes,
explored
providing
desired
pulsatile
release,
sustained
biphasic
delayed
pH‐sensitive
release.
Additionally,
resulted
from
organizations
electrospun
nanofibers
discussed
delivery,
inner
structures
considered
together
developing
novel
delivery
systems.
future,
related
shape–performance
relationships
at
nanoscale,
besides
size,
structure
structure–performance
relationships,
would
play
important
roles
promoting
developments
field.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
Nano Materials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Despite
relevant
advances,
the
pharmaceutical
industry
continues
to
strive
with
limited
adaptability,
moisture
management,
and
discomfort
caused
by
existing
wound
dressings.
Adding
these
challenges
are
bioavailability
pharmacokinetics
of
common
(bio)therapeutics,
overall
leading
unmet
clinical
demands,
safety
concerns,
poor
patient
compliance.
Ionogels,
a
versatile
class
materials
comprising
ionic
liquids
(ILs)
confined
in
an
organic
or
inorganic
solid
network,
have
been
proposed
overcome
drawbacks.
They
demonstrated
ability
enhance
antimicrobial
mechanical
properties
resulting
while
allowing
remarkable
improvements
drug
solubility
their
delivery
targeted
sites.
Nowadays,
investigations
trials
still
required
fully
leverage
potential
ionogels
for
human
applications.
However,
recent
FDA
approval
New
Drug
Application
MRX-5LBT®,
transdermal
system,
opens
promising
perspectives
toward
translation
ionogels.
This
review
focuses
on
advances
achieved
design
applications,
viz.
topical
formulations
promote
healing
activity,
as
platforms
improve
(solubility
bioavailability),
at
specific
sites
controlled
release
behaviour.
The
management
of
wound
exudate
is
vital
importance
for
healing.
Exudate
accumulation
around
prolongs
inflammation
and
hinders
Although
traditional
dressings
can
absorb
exudate,
they
are
unable
to
drain
in
time,
often
resulting
a
poor
feature
with
In
recent
years,
the
appearance
asymmetric
wettability
has
shown
great
potential
management.
Here,
we
summarize
latest
progress
3
kinds
management,
including
Janus
structure,
sandwich
gradient
structure.
most
common
structural
dressing
among
highlighted
from
2
aspects:
single-layer
modified
structure
double-layer
challenges
faced
by
discussed,
developing
trends
smart
this
field
prospected.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2025,
Номер
unknown, С. 1 - 22
Опубликована: Март 13, 2025
Nowadays,
extensive
research
has
been
conducted
on
electrospun
nanofibers
for
wound
dressing
applications.
Considering
the
growing
concern
over
bacterial
resistance
to
common
antibiotics,
investigating
potential
of
natural
essential
oils
with
antibacterial
properties
could
prove
be
beneficial
in
addressing
this
issue.
In
response
challenges
posed
by
impaired
healing,
we
have
designed
a
novel
polyvinyl
alcohol/chitosan
nanofiber
embedded
myrtle
oil
and
gum
Arabic
dispersion
(PVA/CS/MT-GA).
The
morphology
molecular
structure
prepared
were
evaluated
scanning
electron
microscopy
(SEM)
Fourier
transform
infrared
(FTIR)
analysis.
synthesized
PVA/CS/MT-GA
composite
demonstrated
remarkable
swelling
capacity
744%
exhibited
acceptable
mechanical
strength.
Additionally,
water
vapor
transmission
rate
(WVTR)
these
was
obtained
as
2497
g.m−2.day−1,
which
falls
within
ideal
range
dressings.
antimicrobial
test
results
revealed
that
notable
when
tested
against
Escherichia
coli
Staphylococcus
aureus.
release
profile
MT
from
MT-containing
burst
mechanism
nanofibers,
can
applications
require
an
immediate
therapeutic
effect.
Furthermore,
dressings
full-thickness
model
Wistar
rats
care
damaged
tissue
promote
faster
healing
times.
Collectively,
study
suggest
developed
holds
great
promise
candidate
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2025,
Номер
unknown, С. 1 - 31
Опубликована: Апрель 17, 2025
Although
the
skin
has
a
high
healing
capacity,
severe
wounds
often
require
external
interventions
to
heal
properly.
Tissue-engineered
wound
dressings
have
indeed
gained
significant
attention
among
various
treatment
strategies
for
healing.
This
study
focuses
on
integration
of
polyvinyl
pyrrolidone
(PVP),
quaternized
chitosan
(QCS),
and
dextran
(DEX)
prepare
ternary
composite
(PVP/QCS/DEX)
as
dressing
hydrogels
with
varying
concentration
PVP
DEX.
A
variety
analytical
methods,
including
infrared
spectroscopy
(FTIR),
scanning
electron
microscopy
(SEM),
contact
angle,
water
vapor
transmission
rate
(WVTR)
were
employed
assess
characteristics
samples.
The
uniform
interconnected
porous
structure
samples
was
confirmed
by
SEM
results.
All
showed
porosity
transition
rate,
demonstrating
their
ability
provide
suitable
moist
environment
efficient
exudate
handling
antibacterial
test
conducted
demonstrated
activity
drug-loaded
hydrogel
Escherichia
coli
Staphylococcus
aureus.
in
vitro
cytotoxicity
evaluation
using
MTT
assay
that
developed
PVP/QCS/DEX
exhibit
satisfactory
cytocompatibility
promote
cell
viability.
results
scratch
indicated
had
promoted
migration
would
improve
accelerate
process.
vivo
tests
sample
revealed
promising
performance.
Therefore,
based
favorable
performance
observed
throughout
analysis,
as-prepared
show
promise
field
dressings.
