Analytical Chemistry,
Год журнала:
2023,
Номер
95(14), С. 5937 - 5945
Опубликована: Март 27, 2023
While
great
progress
in
nanozyme-enabled
analytical
chemistry
has
been
made,
most
current
nanozyme-based
biosensing
platforms
are
based
on
peroxidase-like
nanozymes.
However,
nanozymes
with
multienzymatic
activities
can
influence
the
detection
sensitivity
and
accuracy,
while
use
of
unstable
hydrogen
peroxide
(H2O2)
a
catalytic
reaction
may
result
reproducibility
challenge
sensing
signals.
We
envision
that
constructing
systems
by
using
oxidase-like
address
these
limitations.
Herein,
we
reported
platinum–nickel
nanoparticles
(Pt–Ni
NPs)
Pt-rich
shells
Ni-rich
cores
possessed
high
efficiency,
exhibiting
2.18-fold
higher
maximal
velocity
(vmax)
than
initial
pure
Pt
NPs.
The
Pt–Ni
NPs
were
applied
to
develop
colorimetric
assay
for
determination
total
antioxidant
capacity
(TAC).
levels
four
bioactive
small
molecules,
two
nanomaterials,
three
cells
successfully
measured.
Our
work
not
only
provides
new
insights
preparing
highly
active
but
also
manifests
their
applications
TAC
analysis.
ACS Nano,
Год журнала:
2023,
Номер
17(6), С. 5211 - 5295
Опубликована: Март 9, 2023
Humans
rely
increasingly
on
sensors
to
address
grand
challenges
and
improve
quality
of
life
in
the
era
digitalization
big
data.
For
ubiquitous
sensing,
flexible
are
developed
overcome
limitations
conventional
rigid
counterparts.
Despite
rapid
advancement
bench-side
research
over
last
decade,
market
adoption
remains
limited.
To
ease
expedite
their
deployment,
here,
we
identify
bottlenecks
hindering
maturation
propose
promising
solutions.
We
first
analyze
achieving
satisfactory
sensing
performance
for
real-world
applications
then
summarize
issues
compatible
sensor-biology
interfaces,
followed
by
brief
discussions
powering
connecting
sensor
networks.
Issues
en
route
commercialization
sustainable
growth
sector
also
analyzed,
highlighting
environmental
concerns
emphasizing
nontechnical
such
as
business,
regulatory,
ethical
considerations.
Additionally,
look
at
future
intelligent
sensors.
In
proposing
a
comprehensive
roadmap,
hope
steer
efforts
towards
common
goals
guide
coordinated
development
strategies
from
disparate
communities.
Through
collaborative
efforts,
scientific
breakthroughs
can
be
made
sooner
capitalized
betterment
humanity.
Nano-Micro Letters,
Год журнала:
2021,
Номер
13(1)
Опубликована: Июль 9, 2021
Since
the
ferromagnetic
(Fe3O4)
nanoparticles
were
firstly
reported
to
exert
enzyme-like
activity
in
2007,
extensive
research
progress
nanozymes
has
been
made
with
deep
investigation
of
diverse
and
rapid
development
related
nanotechnologies.
As
promising
alternatives
for
natural
enzymes,
have
broadened
way
toward
clinical
medicine,
food
safety,
environmental
monitoring,
chemical
production.
The
past
decade
witnessed
metal-
metal
oxide-based
owing
their
remarkable
physicochemical
properties
parallel
low
cost,
high
stability,
easy
storage.
It
is
widely
known
that
study
catalytic
activities
mechanism
sheds
significant
influence
on
applications
nanozymes.
This
review
digs
into
characteristics
intrinsic
nanozymes,
especially
emphasizing
recent
biological
analysis,
relieving
inflammation,
antibacterial,
cancer
therapy.
We
also
conclude
present
challenges
provide
insights
future
constituted
oxide
nanomaterials.
Abstract
Metal‐free
carbon
nanozymes
could
be
promising
with
the
unique
features
of
intrinsic
catalytic
ability,
structure
diversity,
and
strong
tolerance
to
acidic/alkaline
media.
However,
date,
study
metal‐free
fell
far
behind
metal‐based
nanomaterials,
in
which,
majority
reported
much
more
peroxidase‐like
activity
than
other
enzyme‐mimicking
behavior
(e.g.,
oxidase).
Thus,
exploit
high‐performance
is
importance
but
challenging.
In
this
work,
nitrogen‐rich
conjugated
polymer
(Aza‐CPs)
rigid
network
utilized
as
precursor
yield
N
‐doped
material
QAU‐Z1
high
via
a
direct
pyrolysis
method.
Surprisingly,
stood
out
oxidase‐like
behavior,
which
significantly
outperformed
control
materials
GNC‐900
QAU‐Z2
nucleobase
or
small
molecule
precursor,
respectively.
More
importantly,
it
crucial
revelation
that
performance
closely
related
change
zeta
potential
for
nanozyme
during
substrate
3,3′,5,5′‐tetramethylbenzidine
oxidation
process,
well
its
catalytical
capacity
O
2
,
insightful
understand
inherent
mechanism.
This
work
not
only
presents
polymers
constructing
highly
efficient
nanozyme,
also
reveals
vital
role
interaction
mode
between
performance.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
ACS Nano,
Год журнала:
2021,
Номер
15(12), С. 18822 - 18847
Опубликована: Ноя. 29, 2021
The
noble
metal
nanoparticle
has
been
widely
utilized
as
a
plasmonic
unit
to
enhance
biosensors,
by
leveraging
its
electric
and/or
optical
properties.
Integrated
with
the
"flexible"
feature,
it
further
enables
opportunities
in
developing
healthcare
products
conformal
and
adaptive
fashion,
such
wrist
pulse
tracers,
body
temperature
trackers,
blood
glucose
monitors,
etc.
In
this
work,
we
present
holistic
review
of
recent
advance
flexible
biosensors
for
sector.
technical
spectrum
broadly
covers
design
selection
substrate,
process
integrate
units,
exploration
different
types
monitor
human
temperature,
glucose,
ions,
gas,
motion
indicators,
well
their
applications
surface-enhanced
Raman
scattering
(SERS)
colorimetric
detections.
Their
fundamental
working
principles
structural
innovations
are
scoped
summarized.
challenges
prospects
articulated
regarding
critical
importance
continued
progress
improve
living
quality.
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(50)
Опубликована: Сен. 8, 2021
Abstract
Multiple
enzyme‐driven
biological
catalytic
cascades
occur
in
living
organisms,
guiding
highly
efficient
and
selective
transformations
of
substrates.
Inspired
by
the
merits
these
cascade
systems,
enormous
efforts
have
been
devoted
to
developing
novel
systems
mimic
reactions
over
past
few
years.
Nanozymes,
a
class
enzyme
mimics,
are
nanomaterials
with
enzyme‐like
activity.
The
emergence
development
nanozymes
has
significantly
advanced
biomimetic
nanoreactors.
Currently,
nanoreactors
driven
widely
used
exhibit
many
advantages
such
as
superior
efficiency
high
stability,
resulting
significant
advancements
biosensing
biomedical
applications.
latest
advances
understanding
mechanism
nanozyme‐engineered
their
progressive
applications
for
comprehensively
covered
here.
First,
nanozyme
enzyme/nanozyme‐engineered
categorized
according
properties.
Then,
applications,
including
cancer
therapy,
antibacterial
activity,
antioxidation,
hyperuricemia
therapy
covered.
conclusion
describes
most
important
challenges
opportunities
remaining
this
exciting
area
research.
