Analytical Chemistry,
Год журнала:
2023,
Номер
95(14), С. 5937 - 5945
Опубликована: Март 27, 2023
While
great
progress
in
nanozyme-enabled
analytical
chemistry
has
been
made,
most
current
nanozyme-based
biosensing
platforms
are
based
on
peroxidase-like
nanozymes.
However,
nanozymes
with
multienzymatic
activities
can
influence
the
detection
sensitivity
and
accuracy,
while
use
of
unstable
hydrogen
peroxide
(H2O2)
a
catalytic
reaction
may
result
reproducibility
challenge
sensing
signals.
We
envision
that
constructing
systems
by
using
oxidase-like
address
these
limitations.
Herein,
we
reported
platinum–nickel
nanoparticles
(Pt–Ni
NPs)
Pt-rich
shells
Ni-rich
cores
possessed
high
efficiency,
exhibiting
2.18-fold
higher
maximal
velocity
(vmax)
than
initial
pure
Pt
NPs.
The
Pt–Ni
NPs
were
applied
to
develop
colorimetric
assay
for
determination
total
antioxidant
capacity
(TAC).
levels
four
bioactive
small
molecules,
two
nanomaterials,
three
cells
successfully
measured.
Our
work
not
only
provides
new
insights
preparing
highly
active
but
also
manifests
their
applications
TAC
analysis.
Biosensors,
Год журнала:
2023,
Номер
13(4), С. 461 - 461
Опубликована: Апрель 5, 2023
This
review
highlights
the
recent
advancements
in
field
of
nanozymes
and
their
applications
development
point-of-care
biosensors.
The
use
as
enzyme-mimicking
components
biosensing
systems
has
led
to
improved
performance
miniaturization
these
sensors.
unique
properties
nanozymes,
such
high
stability,
robustness,
surface
tunability,
make
them
an
attractive
alternative
traditional
enzymes
applications.
Researchers
have
explored
a
wide
range
nanomaterials,
including
metals,
metal
oxides,
metal–organic
frameworks,
for
nanozyme-based
Different
sensing
strategies,
colorimetric,
fluorescent,
electrochemical
SERS,
been
implemented
using
signal-producing
components.
Despite
numerous
advantages,
there
are
also
challenges
associated
with
biosensors,
stability
specificity,
which
need
be
addressed
wider
future
biosensors
looks
promising,
potential
bring
paradigm
shift
biomolecular
sensing.
highly
specific,
multi-enzyme
mimicking
could
lead
creation
sensitive
low-biofouling
Integration
into
diagnostics
promises
revolutionize
healthcare
by
improving
patient
outcomes
reducing
costs
while
enhancing
accuracy
sensitivity
diagnostic
tools.
ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12049 - 12095
Опубликована: Май 2, 2024
Cancer,
as
one
of
the
leading
causes
death
worldwide,
drives
advancement
cutting-edge
technologies
for
cancer
treatment.
Transition-metal-based
nanozymes
emerge
promising
therapeutic
nanodrugs
that
provide
a
reference
therapy.
In
this
review,
we
present
recent
breakthrough
First,
comprehensively
outline
preparation
strategies
involved
in
creating
transition-metal-based
nanozymes,
including
hydrothermal
method,
solvothermal
chemical
reduction
biomimetic
mineralization
and
sol–gel
method.
Subsequently,
elucidate
catalytic
mechanisms
(catalase
(CAT)-like
activities),
peroxidase
(POD)-like
oxidase
(OXD)-like
activities)
superoxide
dismutase
(SOD)-like
along
with
their
activity
regulation
such
morphology
control,
size
manipulation,
modulation,
composition
adjustment
surface
modification
under
environmental
stimulation.
Furthermore,
elaborate
on
diverse
applications
anticancer
therapies
encompassing
radiotherapy
(RT),
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
photothermal
(PTT),
sonodynamic
(SDT),
immunotherapy,
synergistic
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
The
purpose
review
is
to
offer
scientific
guidance
will
enhance
clinical
based
transition
metals.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(14), С. 5937 - 5945
Опубликована: Март 27, 2023
While
great
progress
in
nanozyme-enabled
analytical
chemistry
has
been
made,
most
current
nanozyme-based
biosensing
platforms
are
based
on
peroxidase-like
nanozymes.
However,
nanozymes
with
multienzymatic
activities
can
influence
the
detection
sensitivity
and
accuracy,
while
use
of
unstable
hydrogen
peroxide
(H2O2)
a
catalytic
reaction
may
result
reproducibility
challenge
sensing
signals.
We
envision
that
constructing
systems
by
using
oxidase-like
address
these
limitations.
Herein,
we
reported
platinum–nickel
nanoparticles
(Pt–Ni
NPs)
Pt-rich
shells
Ni-rich
cores
possessed
high
efficiency,
exhibiting
2.18-fold
higher
maximal
velocity
(vmax)
than
initial
pure
Pt
NPs.
The
Pt–Ni
NPs
were
applied
to
develop
colorimetric
assay
for
determination
total
antioxidant
capacity
(TAC).
levels
four
bioactive
small
molecules,
two
nanomaterials,
three
cells
successfully
measured.
Our
work
not
only
provides
new
insights
preparing
highly
active
but
also
manifests
their
applications
TAC
analysis.
