ACS Nano,
Год журнала:
2023,
Номер
17(22), С. 22553 - 22570
Опубликована: Ноя. 9, 2023
Photodynamic
therapy
(PDT)
has
emerged
as
an
efficient
approach
for
non-invasive
cancer
treatment.
However,
organic
small-molecule
photosensitizers
are
often
associated
with
defects
in
hydrophobicity,
poor
photostability,
and
aggregation-caused
quenching,
which
limit
their
application.
Usually,
the
carrier-assisted
drug
delivery
system
is
a
common
strategy
to
solve
above
obstacles,
but
additional
carrier
material
could
increase
risk
of
potential
biological
toxicity.
The
carrier-free
easy
preparation
high
drug-loading
capability
proposed
subsequently
develop
clinical
use
hydrophobic
drugs.
Herein,
we
rationally
designed
three
IR780-based
nanosystems
formed
by
carbon/disulfide/diselenide
bond
conjugated
homodimers.
homodimers
self-assemble
form
nanoparticles
(DC-NP,
DS-NP,
DSe-NP)
exhibited
higher
reactive
oxygen
species
generation
photostability
than
free
IR780,
DSe-NP
808
nm
laser
irradiation
performed
best
resulted
strongest
cytotoxicity
4T1
cells.
Meanwhile,
glutathione
consumption
ability
boosted
its
PDT
effect
then
induced
excessive
oxidative
stress
cells,
increasing
antitumor
efficacy
enhancing
immunogenic
cell
death
further.
In
tumor-bearing
mice,
displayed
obvious
tumor
site
accumulation,
obviously
inhibited
growth
metastasis,
enhanced
immunological
effectively
inducing
dendritic
cells
mature
activating
T
lymphocytes
natural
killer
summary,
our
study
presented
nanodelivery
combination
immunity
established
expanding
application
system.
Acta Materia Medica,
Год журнала:
2023,
Номер
2(1)
Опубликована: Янв. 1, 2023
The
compound
7-ethyl-10-hydroxy-camptothecin
(SN38)
is
a
broad-spectrum
antitumor
agent
whose
applications
are
greatly
limited
by
its
poor
solubility.
Therefore,
irinotecan,
the
hydrophilic
derived
prodrug
of
SN38,
has
been
developed
as
commercial
formulation
Campto
®
for
colorectal
cancer.
However,
only
1%
to
0.1%
irinotecan
converted
active
SN38
in
vivo,
thus
leading
unsatisfactory
activity
clinical
settings.
Herein,
we
report
smart
stimuli-responsive
nanoassembly
efficient
cancer
therapy.
First,
was
conjugated
with
an
endogenous
lipid,
cholesterol
(CST),
via
redox
dual-responsive
disulfide
bond
(namely
SN38-SS-CST).
self-assembled
into
uniform
nanoassemblies
good
colloidal
stability
and
ultrahigh
drug
loading.
SN38-SS-CST
NPs
released
sufficient
environments
tumor
cells
but
remained
intact
normal
tissues.
Finally,
potently
inhibited
growth
colon
without
causing
systemic
toxicity,
indicating
their
promise
translational
chemotherapeutic
nanomedicine.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(4)
Опубликована: Окт. 24, 2023
Abstract
Triple‐negative
breast
cancer
(TNBC)
is
endowed
with
a
highly
aggressive
nature
that
results
in
distant
metastases
and
high
recurrence
rates,
yet
limited
success
realized
traditional
chemotherapy.
Activatable
photosensitizers
(PSs)
may
provide
an
effective
non‐invasive
strategy
to
induce
TNBC
cell
death
precise
way
by
offering
stimuli‐responsive
reactive
oxygen
species
(ROS).
However,
the
toxicity
of
ROS
often
mitigated
even
devitalized
instinctive
behavior
resistance
cells.
To
address
this
issue,
herein
small
molecular
self‐assembly
nano‐prodrug
presented
co‐deliver
activatable
PS
inhibitor.
In
cells,
overexpressed
glutathione
can
disassemble
nano‐prodrug,
thereby
releasing
inhibitor
activating
for
photodynamic
therapy
fluorescence
imaging.
A
hybrid
membrane
coating‐assisted
nanoparticle
formation
further
demonstrated
efficient
inhibition
tumor
growth
on
both
subcutaneous
orthotopic
mice
models.
ACS Nano,
Год журнала:
2023,
Номер
17(22), С. 22553 - 22570
Опубликована: Ноя. 9, 2023
Photodynamic
therapy
(PDT)
has
emerged
as
an
efficient
approach
for
non-invasive
cancer
treatment.
However,
organic
small-molecule
photosensitizers
are
often
associated
with
defects
in
hydrophobicity,
poor
photostability,
and
aggregation-caused
quenching,
which
limit
their
application.
Usually,
the
carrier-assisted
drug
delivery
system
is
a
common
strategy
to
solve
above
obstacles,
but
additional
carrier
material
could
increase
risk
of
potential
biological
toxicity.
The
carrier-free
easy
preparation
high
drug-loading
capability
proposed
subsequently
develop
clinical
use
hydrophobic
drugs.
Herein,
we
rationally
designed
three
IR780-based
nanosystems
formed
by
carbon/disulfide/diselenide
bond
conjugated
homodimers.
homodimers
self-assemble
form
nanoparticles
(DC-NP,
DS-NP,
DSe-NP)
exhibited
higher
reactive
oxygen
species
generation
photostability
than
free
IR780,
DSe-NP
808
nm
laser
irradiation
performed
best
resulted
strongest
cytotoxicity
4T1
cells.
Meanwhile,
glutathione
consumption
ability
boosted
its
PDT
effect
then
induced
excessive
oxidative
stress
cells,
increasing
antitumor
efficacy
enhancing
immunogenic
cell
death
further.
In
tumor-bearing
mice,
displayed
obvious
tumor
site
accumulation,
obviously
inhibited
growth
metastasis,
enhanced
immunological
effectively
inducing
dendritic
cells
mature
activating
T
lymphocytes
natural
killer
summary,
our
study
presented
nanodelivery
combination
immunity
established
expanding
application
system.
