Biodegradable FePS 3 nanoplatform for efficient treatment of osteosarcoma by combination of gene and NIR-II photothermal therapy DOI Creative Commons
Tingting Luo, Mingyang Jiang, Ziqiang Cheng

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Фев. 28, 2023

Abstract Background As a common tumor with high incidence, osteosarcoma possesses extremely poor prognosis and mortality. Improving the survival of patients is still great challenge due to precipice advancement in treatment. This study aims develop multifunctional nanoplatform based on synergistic effect NIR-II photothermal therapy (PTT) gene for efficient treatment osteosarcoma. Methods In this study, combination strategy developed Two-dimensional (2D) FePS 3 nanosheets are synthesized functionalized by poly-L-lysine-PEG-folic acid (PPF) fabricate (FePS@PPF) further loading microRNAs inhibitor, miR-19a inhibitor (anti-miR-19a). Results The conversion efficiency FePS@PPF up 47.1% under irradiation 1064 nm laser. vitro shows that anti-miR-19a can be efficiently internalized into cells through protection delivery nanao carrier, which induces up-regulation PTEN down-regulation p-AKT gene. After intravenous injection, specifically accumulates site osteosarcoma-bearing mice. vivo investigations reveal combined PTT-gene displays most significant ablation compared monotherapy. More importantly, good biodegradability promotes cleared from body avoiding potential toxicity long-term retention. Conclusion Our work not only develops PTT mediated anti-miR-19a/FePS@PPF but also provides insights design applications other nanotherapeutic platforms.

Язык: Английский

Interfacial engineering of Ti3C2-TiO2 MXenes by managing surface oxidation behavior for enhanced sonodynamic therapy DOI Open Access

Jiaqing Xu,

Xin Wang, Ying Liu

и другие.

Acta Biomaterialia, Год журнала: 2023, Номер 175, С. 307 - 316

Опубликована: Дек. 29, 2023

Язык: Английский

Процитировано

6
Strong hybridization of Nb2C with MoS2: a way to reduce contact resistance DOI

Jinxin Zan,

Huan Wang,

Bairui Tao

и другие.

Journal of Physics D Applied Physics, Год журнала: 2024, Номер 57(32), С. 325103 - 325103

Опубликована: Май 9, 2024

Abstract The hybridization of MXene materials and transition metal dichalcogenides has a significant impact on heterojunction properties. transport properties electronic structure heterojunctions semiconducting MoS 2 metallic Nb C were studied by integrating density functional theory with non-equilibrium Green’s function theory. between makes the tunneling barrier two layers disappear, which can enhance electron injection efficiency from to . Moreover, C/MoS exhibits conventional n-type Schottky contact height 0.14 eV, is significantly lower than 0.29 eV at Ti/MoS junction. These factors result in field-effect transistor low resistance 138 Ω· μ m higher current 1.09 mA −1 bias voltage 0.3 V applied left right electrodes. Following application gate voltage, I / off ratio reaches 1266.

Язык: Английский

Процитировано

0
Biodegradable FePS 3 nanoplatform for efficient treatment of osteosarcoma by combination of gene and NIR-II photothermal therapy DOI Creative Commons
Tingting Luo, Mingyang Jiang, Ziqiang Cheng

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Фев. 28, 2023

Abstract Background As a common tumor with high incidence, osteosarcoma possesses extremely poor prognosis and mortality. Improving the survival of patients is still great challenge due to precipice advancement in treatment. This study aims develop multifunctional nanoplatform based on synergistic effect NIR-II photothermal therapy (PTT) gene for efficient treatment osteosarcoma. Methods In this study, combination strategy developed Two-dimensional (2D) FePS 3 nanosheets are synthesized functionalized by poly-L-lysine-PEG-folic acid (PPF) fabricate (FePS@PPF) further loading microRNAs inhibitor, miR-19a inhibitor (anti-miR-19a). Results The conversion efficiency FePS@PPF up 47.1% under irradiation 1064 nm laser. vitro shows that anti-miR-19a can be efficiently internalized into cells through protection delivery nanao carrier, which induces up-regulation PTEN down-regulation p-AKT gene. After intravenous injection, specifically accumulates site osteosarcoma-bearing mice. vivo investigations reveal combined PTT-gene displays most significant ablation compared monotherapy. More importantly, good biodegradability promotes cleared from body avoiding potential toxicity long-term retention. Conclusion Our work not only develops PTT mediated anti-miR-19a/FePS@PPF but also provides insights design applications other nanotherapeutic platforms.

Язык: Английский

Процитировано

0