Achieving
accurate
and
efficient
tumor
imaging
is
crucial
in
the
field
of
treatment,
as
it
facilitates
early
detection
precise
localization
tissues,
thereby
informing
therapeutic
strategies
surgical
interventions.
The
optical
technology
within
second
near-infrared
(NIR-II)
window
has
garnered
significant
interest
for
its
remarkable
benefits,
such
enhanced
tissue
penetration
depth,
superior
signal-to-background
ratio
(SBR),
minimal
autofluorescence,
reduced
photon
attenuation,
lower
scattering.
This
review
explained
design
optimization
nano-agents
responsive
to
NIR-II
window,
single-walled
carbon
nanotubes,
quantum
dots,
lanthanum-based
nanomaterials,
noble
metal
nanomaterials.
These
enable
non-invasive,
deep-tissue
with
high
spatial
resolution
their
properties
significantly
improve
accuracy,
efficiency,
versatility
imaging-guided
treatments.
And
we
discussed
characteristics
advantages
fluorescence
(FL)/photoacoustic
(PA)
providing
a
comprehensive
overview
latest
research
progress
different
FL/PA
therapy.
Furthermore,
exhaustively
reviewed
applications
multifunctional
nano-phototherapy
technologies
carried
out
by
light
including
photothermal
therapy
(PTT),
photodynamic
(PDT),
combined
modalities
like
photothermal-chemodynamic
(PTT-CDT),
photothermal-chemotherapy
(PTT-CT),
photothermal-
immunotherapy
(PTT-IO).
integrated
approaches
have
gradually
matured
over
past
decade
are
expected
become
safe
effective
non-invasive
treatment.
Finally,
outlined
prospects
challenges
development
innovation
diagnosis
nanoplatform.
aims
provide
insightful
perspectives
future
advancements
treatment
platforms.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Май 16, 2024
Abstract
Chemodynamic
therapy
(CDT)
has
emerged
as
a
transformative
paradigm
in
the
realm
of
reactive
oxygen
species
‐mediated
cancer
therapies,
exhibiting
its
potential
sophisticated
strategy
for
precise
and
effective
tumor
treatment.
CDT
primarily
relies
on
metal
ions
hydrogen
peroxide
to
initiate
Fenton
or
Fenton‐like
reactions,
generating
cytotoxic
hydroxyl
radicals.
Its
notable
advantages
treatment
are
demonstrated,
including
specificity,
autonomy
from
external
triggers,
favorable
side‐effect
profile.
Recent
advancements
nanomedicine
devoted
enhancing
CDT,
promising
comprehensive
optimization
efficacy.
This
review
systematically
elucidates
cutting‐edge
achievements
chemodynamic
nanotherapeutics,
exploring
strategies
enhanced
improved
microenvironment
modulation,
regulation
energy
metabolism.
Moreover,
detailed
analysis
diverse
CDT‐mediated
combination
therapies
is
provided.
Finally,
concludes
with
discussion
prospects
intrinsic
challenges
application
nanotherapeutics
domain
Advanced Materials,
Год журнала:
2024,
Номер
36(45)
Опубликована: Сен. 17, 2024
Abstract
The
overexpression
of
polyamines
in
tumor
cells
contributes
to
the
establishment
immunosuppressive
microenvironment
and
facilitates
growth.
Here,
it
have
ingeniously
designed
multifunctional
copper‐piceatannol/HA
nanopills
(Cu‐Pic/HA
NPs)
that
effectively
cause
total
intracellular
depletion
by
inhibiting
synthesis,
depleting
polyamines,
impairing
uptake,
resulting
enhanced
pyroptosis
cuproptosis,
thus
activating
a
powerful
immune
response
achieve
anti‐tumor
therapy.
Mitochondrial
dysfunction
from
overall
not
only
leads
surge
copper
ions
mitochondria,
thereby
causing
aggregation
toxic
proteins
induce
but
also
triggers
accumulation
reactive
oxygen
species
(ROS)
within
which
further
upregulates
expression
zDHHC5
zDHHC9
promote
palmitoylation
gasdermin
D
(GSDMD)
GSDMD‐N,
ultimately
inducing
pyroptosis.
Then
occurrence
cuproptosis
is
conductive
remodel
microenvironment,
responses
growth
metastasis.
This
therapeutic
strategy
through
comprehensive
provides
novel
template
for
cancer
immunotherapy.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Авг. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Июнь 25, 2024
Abstract
Cuproptosis,
a
newly
identified
copper
(Cu)-dependent
form
of
cell
death,
stands
out
due
to
its
distinct
mechanism
that
sets
it
apart
from
other
known
death
pathways.
The
molecular
underpinnings
cuproptosis
involve
the
binding
Cu
lipoylated
enzymes
in
tricarboxylic
acid
cycle.
This
interaction
triggers
enzyme
aggregation
and
proteotoxic
stress,
culminating
death.
specific
has
yet
be
fully
elucidated.
recognized
sparked
numerous
investigations
into
role
tumorigenesis
cancer
therapy.
In
this
review,
we
summarized
current
knowledge
on
metabolism
link
cancer.
Furthermore,
delineated
mechanisms
roles
cuproptosis-related
genes
Finally,
offered
comprehensive
discussion
most
recent
advancements
ionophores
nanoparticle
delivery
systems
utilize
as
cutting-edge
strategy
for
treatment.
Abstract
Cancer
remains
one
of
the
leading
causes
death
individuals
globally.
Conventional
treatment
techniques
like
chemotherapy
and
radiation
often
suffer
various
drawbacks
toxicity
drug
resistance.
The
study
cell
has
been
predominantly
focused
on
classical
forms
apoptosis,
but
role
metal
ions
in
governing
controlled
is
a
fascinating
less
explored
area.
Metal‐mediated
process
where
triggers
via
unique
mechanism.
Nanomaterial‐based
strategies
have
gained
attention
for
their
ability
to
deliver
precise
therapeutic
agents
while
also
triggering
Regulated
Cell
Death
(RCD)
mechanisms
cancer
cells.
recently
discovered
metal‐mediated
cuproptosis
ferroptosis
can
be
used
as
they
selectively
drug‐resistant
cancer.
Nano
material‐based
delivery
system
targeted
sites.
In
this
review,
we
given
some
idea
about
mechanism
(ferroptosis
cuproptosis)
how
initiate
deaths
using
nanomaterials
treatment.
Abstract
Nanocatalytic
platforms
are
promising
in
cancer
therapeutics
via
combining
multiple
treatments,
which
can
be
leveraged
through
the
metabolic
dysfunction
progression.
However,
lack
of
effective
tumor
delivery
hampers
this
approach.
Here,
a
gelatin‐based
platform
is
designed
that
preloaded
with
gold
nanoparticles
and
photothermal
polypyrrole
(GNPs@AuNPs‐PPy)
an
acid‐induced
doping
enhancement.
Benefiting
from
associated
overexpression
H
2
O
,
peroxidase‐like
Au
induce
burst
oxidative
reactive
oxygen
species
local
microenvironment
(TME).
Subsequent
orchestration
redox
surroundings
recruits
immune
cells,
showcasing
antineoplastic
pathway.
Under
near
infrared
light
(NIR)
irradiation,
nanohybrids
exhibit
dual
pH/NIR
enhanced
drug
release
within
TME,
while
allowing
for
multimodal
imaging‐guided
theranostics.
Leveraging
modality,
GNPs@AuNPs‐PPy
delivers
quercetin
(a
natural
antitumor
mediator)
boosting
anti‐tumor
therapy.
The
gelatin‐mediated
nanomedicine
provides
alternative
combinatorial
dynamic
treatment.
