Materials Today Bio, Год журнала: 2024, Номер 30, С. 101386 - 101386
Опубликована: Дек. 9, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101626 - 101626
Опубликована: Март 1, 2025
Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive innovative perspective on how nanomedicine can modify TME to enhance therapy. Strategies include using nanoparticles improve oxygenation, adjust acidity, alter extracellular matrix, making treatments more effective. Additionally, immune responses activating cells reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy radiotherapy, show promise in overcoming traditional barriers. The discusses changes effectiveness of itself, creating reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting TME, leveraging nanoparticle-based for targeted therapy through precise modulation.
Язык: Английский
Процитировано
4
Materials Today Communications, Год журнала: 2025, Номер 45, С. 112260 - 112260
Опубликована: Март 18, 2025
Язык: Английский
Процитировано
1
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(9), С. 10444 - 10461
Опубликована: Сен. 20, 2024
Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays critical role in maintaining skin structure and hydration. Its unique properties make it valuable component the field of nanopharmaceuticals. The combination HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving delivery efficacy drugs. HA-based nanoparticles, including solid lipid polymeric nanogels, offer controlled release, enhanced stability, targeted agents. These innovations significantly improve outcomes reduce side effects, making an essential tool modern medicine. In general, HA-modified liposomes enhance drug encapsulation targeting, while nanoparticles (SLNs) provide core for encapsulation, offering release stability. This article provides overview potential applications recent advancements nanopharmaceuticals, emphasizing significant impact on evolving advanced strategies. By delving compatibility this review underscores promising revolutionizing
Язык: Английский
Процитировано
8
Designed Monomers & Polymers, Год журнала: 2024, Номер 28(1), С. 1 - 34
Опубликована: Дек. 31, 2024
This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.
Язык: Английский
Процитировано
7
Journal of Nanoparticle Research, Год журнала: 2024, Номер 26(9)
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
5
International Journal of Pharmaceutics, Год журнала: 2024, Номер 662, С. 124529 - 124529
Опубликована: Июль 30, 2024
Pancreatic cancer (PC) is one of the most lethal malignancies worldwide and its incidence increasing. Chemotherapy often associated to limited efficacy, poor targeting systemic toxicity. In this work, hydrophilic gemcitabine (GEM), widely used in PC treatment alone or combination, was conjugated with vitamin E succinate (VES) encapsulated Soluplus® micelles. This prodrug approach facilitated encapsulation anticancer drug into self-assembled copolymer Soluplus®/VES-GEM micelles were optimized regarding ratio components preparation process. The small-sized (<80 nm), monodisperse, highly stable, efficiently retaining conjugate showing significant antiproliferative activity against BxPC3 cell line. To improve biofunctionalization properties prepared micelles, biomimetic modification membrane further attempted by co-extruding (BxPC3) nanovesicles Several protocols prepare BxPC3-modified outcomes analyzed detail. Overall, results pave way innovative PC-targeted nanotherapies maximizing GEM hydrophobic compartments high stability affinity. also highlight need higher resolution techniques characterize coating nanocarriers bearing shells.
Язык: Английский
Процитировано
4
MedComm, Год журнала: 2024, Номер 5(11)
Опубликована: Окт. 20, 2024
Abstract Cancer is a leading cause of morbidity and mortality worldwide, an increase in incidence estimated the next future, due to population aging, which requires development highly tolerable low‐toxicity cancer treatment strategies. The use nanotechnology tailor treatments according genetic immunophenotypic characteristics patient's tumor, allow its targeted release, can meet this need, improving efficacy minimizing side effects. Nanomedicine‐based approach for diagnosis rapidly evolving field. Several nanoformulations are currently clinical trials, some have been approved marketed. However, their large‐scale production still hindered by in‐depth debate involving ethics, intellectual property, safety health concerns, technical issues, costs. Here, we survey key approaches, with specific reference organ‐on chip technology, cutting‐edge tools, such as CRISPR/Cas9 genome editing, through nanosystems needs personalized diagnostics therapy patients. An update provided on nanopharmaceuticals marketed those undergoing trials. Finally, discuss emerging avenues field challenges be overcome transfer nano‐based precision oncology into daily life.
Язык: Английский
Процитировано
4
International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124994 - 124994
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
4
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Polymer-based herbicide nanocarriers have shown potential for increasing the efficacy and environmental safety. This study aimed to develop, characterize, evaluate toxicity target nontarget organisms of natural-based polymeric nanosystems glyphosate. Polymers such as chitosan (CS), zein (ZN), lignin (LG) were used in synthesis. Nanosystem size, surface charge, polydispersity index, encapsulation efficiency, weed species (Amaranthus hybridus, Ipomoea grandifolia, Eleusine indica), Roundup Ready (RR) crops, soil respiration, enzyme activity evaluated. The most stable system was combination ZN with cross-linker poloxamer (PL), higher control (90–96%) A. compared commercial glyphosate (40%). No improvement observed I. grandifolia E. indica. RR or enzymes, indicating no toxic effects nanoformulation these models. ZN-PL systems can be a promising alternative delivery, using environmentally friendly materials, improved efficiency agriculture.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101539 - 101539
Опубликована: Фев. 1, 2025
The treatment outcomes of traditional patches for chronic soft tissue defects (CSTDs) are unsatisfactory in clinical, owing to the lack intrinsic bioactivities orchestrate intricate regenerative process. To tackle this deficiency, nature-derived microneedles (NMs) composed silk methacrylate and snail mucus developed study. resultant NMs have excellent mechanical strength biological adhesiveness, ensuring suture-free but reliable fixation on implanted site. enhance bioactivities, metal-polyphenolic networks (MPNs) coordinated from copper (Cu) curcumin (Cur) designed encapsulated into NMs. Cu-Cur MPNs harness anti-oxidative anti-inflammatory properties Cur with pro-angiogenic Cu, targeting different negative aspects CSTDs repair. Furthermore, pH-responsive disassembly can respond acidic microenvironment, allowing burst-free on-demand drug delivery. Both in-vitro in-vivo experiments demonstrate that encapsulation (Cu-Cur-NMs) restore redox homeostasis, reduce inflammatory response, promote blood vessel formation, thus remodeling microenvironment greatly improve repair quality CSTDs. Therefore, combined advantages microneedles-based patch system MPNs-based nanotherapeutic agent explored first time, our proposed Cu-Cur-NMs represent a multifunctional promising device
Язык: Английский
Процитировано
0