Biomimetic Nanoparticles Inhibit the HIF-1α/iNOS/NLRP3 Pathway to Alleviate Rheumatoid Arthritis DOI

Mo Chen,

Zhenhua Wang,

Haolong Chen

и другие.

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease distinguished by inflammatory synovitis. Chrysin can alleviate the response and inhibit progression of RA. However, unfavorable physicochemical properties nonselective biodistribution chrysin make it difficult to achieve good therapeutic efficacy. To address these challenges, we developed biomimetic nanocarrier enhance targeted delivery synoviocytes, key cellular component in RA pathology. Our nanodrug, FMPlipo@C, was engineered integrating fibroblast-like synoviocyte (FLS) membrane proteins into chrysin-loaded liposomes. This innovative approach harnesses homologous targeting mediated FLS direct liposomes inflamed joints, facilitating cargo release within synoviocytes. We showed that FMPlipo@C reduces inflammation collagen-induced rheumatoid (CIA) model mice inhibiting HIF-1α/iNOS/NLRP3 pathway, protecting cartilage, preventing bone erosion, thus reducing swelling stiffness. study offers valuable insights development novel strategies for treatment

Язык: Английский

Biomimetic Nanoparticles Inhibit the HIF-1α/iNOS/NLRP3 Pathway to Alleviate Rheumatoid Arthritis DOI

Mo Chen,

Zhenhua Wang,

Haolong Chen

и другие.

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease distinguished by inflammatory synovitis. Chrysin can alleviate the response and inhibit progression of RA. However, unfavorable physicochemical properties nonselective biodistribution chrysin make it difficult to achieve good therapeutic efficacy. To address these challenges, we developed biomimetic nanocarrier enhance targeted delivery synoviocytes, key cellular component in RA pathology. Our nanodrug, FMPlipo@C, was engineered integrating fibroblast-like synoviocyte (FLS) membrane proteins into chrysin-loaded liposomes. This innovative approach harnesses homologous targeting mediated FLS direct liposomes inflamed joints, facilitating cargo release within synoviocytes. We showed that FMPlipo@C reduces inflammation collagen-induced rheumatoid (CIA) model mice inhibiting HIF-1α/iNOS/NLRP3 pathway, protecting cartilage, preventing bone erosion, thus reducing swelling stiffness. study offers valuable insights development novel strategies for treatment

Язык: Английский

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