Sex-Linked Biology and Gender-Related Research Is Essential to Advancing Hearing Health

Ear and Hearing, Год журнала: 2022, Номер 44(1), С. 10 - 27

Опубликована: Ноя. 17, 2022

There is robust evidence that sex (biological) and gender (behavioral/social) differences influence hearing loss risk outcomes. These are noted for animals humans-in the occurrence of loss, progression, response to interventions. Nevertheless, many studies have not reported or disaggregated data by gender. This article describes sex-linked biology (specifically hormones) on interventions, including role in modifying association between factors effects quality life functioning. Most prevalence indicate begins earlier more common severe among men than women. Intrinsic biological auditory system may account, part, predominance males. Sex- gender-related noise exposure cardiovascular disease help explain some these loss. Further still, aid use uptake, health also vary Recognizing key determinants health, present review concludes emphasizing importance a well-developed research platform proactively measures assesses sex- hearing, understudied populations. Such focus necessary advance field science benefit all members society.

Язык: Английский

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White matter integrity of hearing and cognitive impairments in healthy aging

NeuroImage, Год журнала: 2025, Номер unknown, С. 121135 - 121135

Опубликована: Март 1, 2025

Age-Related Hearing Loss (ARHL), or presbycusis, affects two-thirds of U.S. adults over 70 and is linked to cognitive decline an increased risk dementia. This study examines associations between white matter integrity hearing function in healthy aging using diffusion tensor imaging (DTI). We recruited 126 participants (92 female) aged 20-79 years (Mean=51.34,SD=20.54) from the Aging Brain Cohort Study at University South Carolina (ABC@UofSC). Cognitive performance was assessed Montreal Assessment (MoCA), evaluated through pure-tone thresholds (PTT) words-in-noise (WIN) thresholds. White measured with fractional anisotropy (FA) mean diffusivity (MD), analyses examined relationships these DTI metrics scores region-of-interest regression analysis. Results showed significant lower FA higher MD values poorer performance, particularly anterior superior corona radiata, corpus callosum, longitudinal fasciculus. Additionally, ANOVA comparisons older without impairments revealed differences several regions, indicating specific microstructural changes auditory impairment. contributes understanding neural bases impairments, underscoring potential as a complementary tool gray matter-based studies exploring reliable evidence across adulthood.

Язык: Английский

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Reduced tactile sensitivity is associated with mild cognitive impairment

EBioMedicine, Год журнала: 2023, Номер 99, С. 104896 - 104896

Опубликована: Дек. 1, 2023

Sensory impairment has been related to age-associated cognitive decline. While these associations were investigated primarily in the auditory and visual domain, other senses such as touch have rarely studied. Thus, it remains open whether results are specific for particular sensory domains, or rather point a fundamental role of deficits

Язык: Английский

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Different neuroanatomical correlates for temporal and spectral supra‐threshold auditory tasks and speech in noise recognition in older adults with hearing impairment

European Journal of Neuroscience, Год журнала: 2023, Номер 57(6), С. 981 - 1002

Опубликована: Янв. 23, 2023

Varying degrees of pure-tone hearing loss in older adults are differentially associated with cortical volume (CV) and thickness (CT) within outside the auditory pathway. This study addressed question to what degree supra-threshold performance (i.e., temporal compression frequency selectivity) as well speech noise (SiN) recognition neurostructural correlates a sample 59 healthy mild moderate loss. Using surface-based morphometry on T1-weighted MRI images, CT, CV, surface area (CSA) several regions-of-interest were obtained. The results showed distinct patterns for different tasks terms involved regions morphometric parameters. While averages (PTAs) positively correlated CT right hemisphere superior sulcus gyrus cluster, perception additionally extended significantly CV left clusters including Heschl's sulcus, planum polare temporale. For SiN recognition, we found significant correlations an auditory-related cluster furthermore language-related areas prefrontal cortex. Taken together, our show that abilities differently morphology impairment. Still, common pattern is greater PTAs poorer all related thinning but not changes CSA. These support hypothesis mostly undergoes alterations context decline, while CSA remains stable.

Язык: Английский

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Effects of cochlear implantation on cognitive decline in older adults: A systematic review and meta-analysis

Heliyon, Год журнала: 2023, Номер 9(9), С. e19703 - e19703

Опубликована: Сен. 1, 2023

Hearing loss has been reported as the most significant modifiable risk factor for dementia, but it is still unknown whether auditory rehabilitation can practically prevent cognitive decline. We aim to systematically analyze longitudinal effects of via cochlear implants (CIs).In this systematic review and meta-analysis, we searched relevant literature published from January 1, 2000 April 30, 2022, using electronic databases, selected studies in which CIs were performed mainly on older adults follow-up assessments conducted both domains: speech perception function. A random-effects meta-analysis was each domain timepoint comparison (pre-CI vs. six months post-CI; post-CI 12 pre-CI post-CI), heterogeneity assessed Cochran's Q test.Of 1918 retrieved articles, 20 research papers (648 CI subjects) included. The results demonstrated that rapidly enhanced after CI, whereas function had different speeds improvement subtypes: executive steadily improved significantly up (g = 0.281, p < 0.001; g 0.115, 0.003; 0.260, 0.001 order comparison); verbal memory at maintained until 0.296, 0.002; 0.095, 0.427; 0.401, 0.001); non-verbal showed no considerable progress post-CI, -0.053, 0.723; 0.112, 0.089; 0.214, 0.023).The outcomes demonstrate could have a long-term positive impact abilities. Given adults' abilities are trajectory progressive decline with age, these highlight need increase adoption among population.

Язык: Английский

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Longitudinal Changes in Resting-State Functional Connectivity and Gray Matter Volume Are Associated with Conversion to Hearing Impairment in Older Adults

Journal of Alzheimer s Disease, Год журнала: 2022, Номер 86(2), С. 905 - 918

Опубликована: Фев. 8, 2022

Hearing loss was recently identified as a modifiable risk factor for dementia although the potential mechanisms explaining this relationship are unknown.

Язык: Английский

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The impact of age-related hearing loss on structural neuroanatomy: A meta-analysis

Frontiers in Neurology, Год журнала: 2022, Номер 13

Опубликована: Авг. 8, 2022

This meta-analysis investigated the association between age-related hearing loss and structural neuroanatomy, specifically changes to gray matter volume. Hearing is associated with increased risk of cognitive decline. Hence, understanding effects in older age on brain health essential. We reviewed studies which compared participants (age-related loss: ARHL) adults without clinical (no-ARHL), neuroanatomical outcomes, (GM) volume as measured by magnetic resonance imaging. A total five met inclusion criteria, three were included an analysis whole-brain (ARHL group n = 113; no-ARHL 138), analyses lobe-wise 139; 162). Effect-size seed-based d mapping software was employed for The indicated there no significant difference ARHL those Due lacking stereotactic coordinates, level specific locations could only be observed at lobe-level. These data indicate that show atrophy temporal lobe (not occipital, parietal, or frontal), no-ARHL. implications theoretical frameworks decline relationship are discussed relation results. pre-registered PROSPERO (CRD42021265375). Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=265375 , CRD42021265375.

Язык: Английский

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Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer’s disease

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 15, 2024

Abstract Hearing is multifaceted and the relative contributions of peripheral central hearing loss are rarely considered together in context dementia. Here, we assessed (as measured with pure-tone audiometry) dichotic listening) 19 patients typical amnestic Alzheimer’s disease (tAD), 10 logopenic variant primary progressive aphasia (lvPPA), 11 nonfluent/agrammatic PPA (nfvPPA), 15 semantic (svPPA), 28 healthy age-matched individuals. Participants also underwent neuropsychological assessment magnetic resonance image scanning, allowing us to use voxel-based morphometry assess associations between scores grey matter volume. Dichotic listening was impaired all patient groups controls. In combined (but not control) cohort, were significantly correlated measures global cognitive functioning speech-based tasks. Pure-tone audiometry elevated any group control group, no significant correlations observed task performance either or cohorts. Neuroanatomically, associated volume a bilateral fronto-temporo-parietal network over but correlates identified for audiometry. Our findings highlight importance speech parsing mechanisms beyond elementary sound detection driving test performance, underline assessing alongside people dementia, further delineate complex auditory profiles neurodegenerative dementias.

Язык: Английский

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EXPRESS: Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer's disease

Quarterly Journal of Experimental Psychology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Hearing is multifaceted, and the relative contributions of peripheral central hearing loss are rarely considered together in context dementia. Here, we assessed (as measured with pure-tone audiometry) dichotic listening) 19 patients typical amnestic Alzheimer’s disease (tAD), 10 logopenic variant primary progressive aphasia (lvPPA), 11 nonfluent/agrammatic PPA (nfvPPA), 15 semantic (svPPA), 28 healthy age-matched individuals. Participants also underwent neuropsychological assessment magnetic resonance image scanning, allowing us to use voxel-based morphometry assess associations between scores grey matter volume. Dichotic listening was impaired all patient groups controls. In combined (but not control) cohort, were significantly correlated measures global cognitive functioning speech-based tasks. Pure-tone audiometry elevated any group control group, no significant correlations observed task performance either or cohorts. Neuroanatomically, associated volume a bilateral fronto-temporoparietal network over but correlates identified for audiometry. Our findings highlight importance speech parsing mechanisms beyond elementary sound detection driving test performance, underline assessing alongside people dementia, further delineate complex auditory profiles neurodegenerative dementias.

Язык: Английский

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A multimodal database for the collection of interdisciplinary audiological research data in Spain

Auditio, Год журнала: 2024, Номер 8, С. e109 - e109

Опубликована: Сен. 27, 2024

Hearing loss constitutes a major disability that hinders communication and quality of life. Recent evidence has uncovered its impact on cognitive decline, thus highlighting multifactorial dimension the outstanding need for creating multimodal hearing datasets further cover clinical data across different health domains. The aim this study is to develop multi-collaborative database systematically collect analyze interdisciplinary audiological research, including auditory thresholds, speech tests, evoked potentials, quality-of-life medical images, among others. been implemented in Otorhinolaryngology Service Virgen Macarena University Hospital Seville, integrated Intranet Andalusian Health Service, connected electronic patients’ records. This relies open-source software complies with national international guidelines protection. A specific registry module designed automatically import thresholds potentials from devices into platform. mobile app also questionnaires patients remotely. demo web version platform freely available audiology community. developed paves way towards unified framework research Spain. Nevertheless, support clinicians healthcare stakeholders remains critical more high-quality open research.

Язык: Английский

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