Sex difference in human diseases: mechanistic insights and clinical implications DOI Creative Commons

Yuncong Shi,

Jianshuai Ma,

Sijin Li

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 10, 2024

Abstract Sex characteristics exhibit significant disparities in various human diseases, including prevalent cardiovascular cancers, metabolic disorders, autoimmune and neurodegenerative diseases. Risk profiles pathological manifestations of these diseases notable variations between sexes. The underlying reasons for sex encompass multifactorial elements, such as physiology, genetics, environment. Recent studies have shown that body systems demonstrate sex-specific gene expression during critical developmental stages editing processes. These genes, differentially expressed based on different sex, may be regulated by androgen or estrogen-responsive thereby influencing the incidence presentation cardiovascular, oncological, metabolic, immune, neurological across However, despite existence differences patients with treatment guidelines predominantly rely male data due to underrepresentation women clinical trials. At present, there exists a substantial knowledge gap concerning mechanisms treatments diverse Therefore, this review aims elucidate advances examining epidemiological factors, pathogenesis, innovative progress accordance distinctive risk each disease provide new theoretical practical basis further optimizing individualized improving patient prognosis.

Язык: Английский

Sex difference in human diseases: mechanistic insights and clinical implications DOI Creative Commons

Yuncong Shi,

Jianshuai Ma,

Sijin Li

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 10, 2024

Abstract Sex characteristics exhibit significant disparities in various human diseases, including prevalent cardiovascular cancers, metabolic disorders, autoimmune and neurodegenerative diseases. Risk profiles pathological manifestations of these diseases notable variations between sexes. The underlying reasons for sex encompass multifactorial elements, such as physiology, genetics, environment. Recent studies have shown that body systems demonstrate sex-specific gene expression during critical developmental stages editing processes. These genes, differentially expressed based on different sex, may be regulated by androgen or estrogen-responsive thereby influencing the incidence presentation cardiovascular, oncological, metabolic, immune, neurological across However, despite existence differences patients with treatment guidelines predominantly rely male data due to underrepresentation women clinical trials. At present, there exists a substantial knowledge gap concerning mechanisms treatments diverse Therefore, this review aims elucidate advances examining epidemiological factors, pathogenesis, innovative progress accordance distinctive risk each disease provide new theoretical practical basis further optimizing individualized improving patient prognosis.

Язык: Английский

Процитировано

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