The gut microbiota–oligodendrocyte axis: A promising pathway for modulating oligodendrocyte homeostasis and demyelination-associated disorders

Life Sciences, Год журнала: 2024, Номер 354, С. 122952 - 122952

Опубликована: Авг. 9, 2024

The bidirectional regulation between the gut microbiota and brain, known as gut-brain axis, has received significant attention. myelin sheath, produced by oligodendrocytes or Schwann cells, is essential for efficient nervous signal transmission maintenance of brain function. Growing evidence shows that both oligodendrogenesis myelination are modulated its metabolites, when dysbiosis occurs, changes in composition and/or associated metabolites may impact developmental occurrence neurodevelopmental disabilities. Although link demyelinating disease such multiple sclerosis been extensively studied, our knowledge about role other myelin-related disorders, neurodegenerative diseases, limited. Mechanistically, microbiota-oligodendrocyte axis primarily mediated factors inflammation, vagus nerve, endocrine hormones, evidenced metagenomics, metabolomics, vagotomy, morphological molecular approaches. Treatments targeting this include probiotics, prebiotics, microbial herbal bioactive compounds, specific dietary management. In addition to commonly used approaches, viral vector-mediated tracing gene manipulation, integrated multiomics multicenter clinical trials will greatly promote mechanistic interventional studies ultimately, development new preventive therapeutic strategies against gut-oligodendrocyte axis-mediated impairments. Interestingly, recent findings showed can be induced hippocampal damage reversible myelin-targeted drugs, which provides insights into understanding how hippocampus-based functional impairment (such Alzheimer's disease) regulates peripheral homeostasis systemic disorders.

Язык: Английский

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Subdiaphragmatic vagotomy reduces hypothalamic oxytocin expression and blood levels after oral MDMA administration in male rats

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер 137, С. 111260 - 111260

Опубликована: Янв. 22, 2025

Язык: Английский

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Repeated intermittent administration of 3,4-methylenedioxymethamphetamine mitigates demyelination in the brain from cuprizone-treated mice

European Journal of Pharmacology, Год журнала: 2025, Номер 991, С. 177345 - 177345

Опубликована: Фев. 2, 2025

3,4-Methylenedioxymethamphetamine (MDMA), commonly known as a recreational drug, may also offer therapeutic benefits for mental health. Population-based studies suggest that MDMA users have lower risk of demyelinating diseases, such depression. Given the role gut microbiota in mediating MDMA's effects, we hypothesized might confer health via gut-brain axis. Cuprizone (CPZ) induces demyelination by chelating copper, which leads to oligodendrocyte death and subsequent myelin loss. This study investigated impact on brain CPZ-treated mice, focusing Repeated intermittent administration (10 mg/kg, three times weekly 6 weeks) significantly reduced corpus callosum (CC) mice. Gut non-targeted metabolomics analyses revealed notable differences specific bacteria plasma (β-D-allose L-sorbose) or fecal metabolite (carnitine) levels between MDMA-treated vehicle-treated CPZ-exposed Negative correlations were found metabolites (β-D-allose, L-sorbose, carnitine) relative abundance Romboutsia timonensis. These findings alleviate CC mice Further research is needed elucidate roles effects investigate other models.

Язык: Английский

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The microbiota-microglia axis: A novel clue for diet and brain health

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104942 - 104942

Опубликована: Фев. 1, 2025

Язык: Английский

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Repeated administration of esketamine ameliorates mechanical allodynia in mice with chemotherapy-induced peripheral neuropathy: A role of gut microbiota and metabolites

Neurochemistry International, Год журнала: 2025, Номер 185, С. 105961 - 105961

Опубликована: Март 5, 2025

Язык: Английский

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