The Role of the Glymphatic Clearance System in the Mechanisms of the Interactions of the Sleep–Waking Cycle and the Development of Neurodegenerative Processes

Neuroscience and Behavioral Physiology, Год журнала: 2024, Номер 54(2), С. 199 - 204

Опубликована: Фев. 1, 2024

Язык: Английский

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The significance of the glymphatic pathway in the relationship between the sleep—wake cycle and neurodegenerative diseases

S S Korsakov Journal of Neurology and Psychiatry, Год журнала: 2023, Номер 123(9), С. 31 - 31

Опубликована: Янв. 1, 2023

Selective and progressive death of neurons is a characteristic feature the process neurodegeneration leads to corresponding neuronal dysfunctions. Neurodegenerative diseases represent heterogeneous group clinically distinct disorders with similar molecular mechanisms pathogenesis. They are based on processes abnormal aggregation proteins, formation fibrillary insoluble structures their deposition in form histopathological inclusions tissues nervous system. Disturbance homeostatic functions that regulate ion energy metabolism, biosynthesis degradation proteins nucleotides, chronic hypoxia penetration toxic inflammatory substances into brain from bloodstream not only cause metabolic changes associated age sleep-wake cycle, but also contribute development neurodegenerative diseases. In animal studies, clearance pathways have been identified which solutes specific tracers excreted perivascular meningeal lymphatics. The glymphatic pathway promotes removal metabolites, including Aβ amyloid tau protein, parenchymal extracellular space brain. system discussed be more efficient during natural sleep, fluid dynamics through this exhibit daily fluctuations under circadian control. This review systematizes key aspects data recent research role astroglial AQP-4 as its main determinant maintaining circulation normal pathological conditions, particular relation regulatory cycle neurodegeneration.Избирательная и прогрессирующая гибель нейронов является характерной чертой процесса нейродегенерации приводит к соответствующим нейрональным дисфункциям. Нейродегенеративные заболевания представляют гетерогенную группу различных по клинической картине нозологий со сходными молекулярными механизмами патогенеза. В их основе лежат процессы аномальной агрегации белков, формирования фибриллярных нерастворимых структур депонирования в виде гистопатологических включений тканях нервной системы. Нарушение гомеостатических функций, регулирующих нейрональный ионный энергетический обмен, биосинтез деградацию белков нуклеотидов, хроническая гипоксия проникновение головной мозг из кровотока токсических воспалительных веществ не только вызывают метаболические изменения, ассоциированные с возрастом нарушениями цикле «сон—бодрствование», но способствуют развитию нейродегенеративных процессов. исследованиях на животных были выявлены пути клиренса, при которых растворенные вещества специфические трассеры выводятся периваскулярным путем менингеальные лимфатические сосуды. Глимфатическая сеть способствует выведению метаболитов, включая бета-амилоид тау-белок, внеклеточного пространства головного мозга. Обсуждается, что глимфатическая система более эффективна во время естественного сна, а гидродинамика через этот путь демонстрирует ежедневные колебания находится под циркадианным контролем. настоящем обзоре систематизированы ключевые аспекты научные данные последних исследований о роли глимфатического астроглиального аквапорина 4-го типа как его основной детерминанты поддержании гомеостатической циркуляции жидкости мозге норме патологии, частности взаимосвязи регулирующей ролью цикла «сон—бодрствование» развитии

Язык: Русский

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Promotion of neuroinflammation by the glymphatic system: a new insight into ethanol extracts from Alisma orientale in alleviating obesity-associated cognitive impairment

Phytomedicine, Год журнала: 2023, Номер 122, С. 155147 - 155147

Опубликована: Окт. 13, 2023

Язык: Английский

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A proposed role for lymphatic supermicrosurgery in the management of Alzheimer’s disease: A primer for reconstructive microsurgeons

Archives of Plastic Surgery, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract The relatively recent discovery of a novel lymphatic system within the brain meninges has spurred interest in how waste products generated by neurons and glial cells—including proteins associated with Alzheimer's disease (AD) pathology such as amyloid beta (Aβ) tau—are disposed of. Evidence is building that suggests progression AD other cognitive impairments could be explained dysfunction brain's or obstruction drainage. An interesting implication this hypothesis that, relieving flow, reconstruction along drainage pathway serve potential treatment. Should concept prove true, it represent surgical solution to problem for which only medical solutions have thus far been considered. This study meant primer reconstructive microsurgeons, introducing topic current hypotheses about role AD. A preview research evaluating feasibility approach improving Aβ clearance provided, aim inspiring others design robust preclinical clinical investigations into intriguing hypothesis.

Язык: Английский

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The Venular Side of Cerebral Amyloid Angiopathy: Proof of Concept of a Neglected Issue

Biomedicines, Год журнала: 2023, Номер 11(10), С. 2663 - 2663

Опубликована: Сен. 28, 2023

Small vessel diseases (SVD) is an umbrella term including several entities affecting small arteries, arterioles, capillaries, and venules in the brain. One of most relevant prevalent SVDs cerebral amyloid angiopathy (CAA), whose pathological hallmark deposition fragments walls cortical leptomeningeal vessels. CAA frequently coexists with Alzheimer’s Disease (AD), both are associated cerebrovascular events, cognitive impairment, dementia. AD share pathophysiological, histopathological neuroimaging issues. The venular involvement has been neglected, although animal models human studies found a beta venules. This review aimed to summarize available information about CAA, starting from biological level putative pathomechanisms damage, passing through definition peculiar angioarchitecture cortex functional organization consequences arteriolar occlusion, ending hypothesized links between main markers disease.

Язык: Английский

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Glymphatic dysfunction in the pathogenesis of neurodegenerative diseases and pathological aging

Genes and Cells, Год журнала: 2023, Номер 18(4), С. 309 - 322

Опубликована: Ноя. 11, 2023

Recently, the concept of glymphatic system as a highly organized perivascular network has been formed, which by hydrodynamic approach, with key participation aquaporin-4 central molecule, connects cerebrospinal fluid lymphatic vessels meninges through brain interstitium. The latest scientific works demonstrates potential role dysfunction in development neurodegeneration and pathological aging. Although precise molecular mechanisms pathway function have not yet fully characterized, critical processes underlying cerebral solute transport clearance amyloid metabolites largely elucidated. complex interaction between number age-associated factors, including cellular aging, disturbances sleep-wake cycle changes sleep architecture quality, low-grade systemic inflammation, concomitant diseases, determines only life expectancy general, but also forms basis healthy unhealthy aging particular. Imbalances homeostatic functions, activity blood-brain barrier that support exchange solutes tissue, can be observed both normally physiological neuropathology, longitudinal consequences ranging from disruption synaptic signal transmission to onset neurodegenerative processes. This review analyzes current information this area research, details features glial-mediated system, discusses how its plays fundamental accumulation during brain, progression diseases.

Язык: Английский

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Alzheimer Dementia as a Consequence of the Brain Glymphatic System Dysfunction

Психиатрия психотерапия и клиническая психология, Год журнала: 2023, Номер 14(3), С. 291 - 300

Опубликована: Ноя. 28, 2023

Определение основных патогенетических механизмов развития наиболее распространенной формы деменции – болезни Альцгеймера, а также поиск эффективных решений для замедления и прекращения прогрессирования заболевания относятся к одним из приоритетных направлений фундаментальной нейробиологии практической медицины. Гипотеза бета-амилоида тау-белка в значительной степени объясняет ключевые патологические особенности альцгеймеровского типа. Системные механизмы молекулярные процессы, вследствие которых такие белки накапливаются приводят прогрессированию заболевания, вызывают выраженный научный практический интерес, что актуализировано сохранением терапевтического пробела определении рациональных вмешательств, модифицирующих болезнь, поиском доступных биомаркеров, высокоинформативных на доклинической стадии нейродегенеративных расстройств у людей без когнитивных нарушений определяемых клинических симптомов. Тем не менее недавнее открытие аквапорин-зависимого глимфатического пути, управляющего центральным клиренсом растворенных веществ головном мозге, выявило новый механизм, лежащий основе патогенеза нейродегенерации нейровоспаления. Настоящий обзор представляет систематизирует современные данные о причинно-следственных связях дисфункции глимфатической системы мозга накопления патологических белков с недостаточным выведением токсических продуктов метаболизма функционального пространства нейронов, являющихся ключевыми звеньями развитии Determination of the main pathological mechanisms development most common form dementia Alzheimer’s disease, as well search for effective solutions to slow down and stop progression is one priority areas fundamental neurobiology practical medicine. The beta-amyloid tau hypothesis largely explains key features dementia. Systemic molecular processes, due which such proteins accumulate lead are great scientific interest, updated by persistence a therapeutic gap in definition rational disease-modifying interventions, available biomarkers that highly informative at preclinical stage neurodegenerative disorders people without cognitive dysfunction. However, recent discovery an aquaporin-dependent glymphatic pathway controls central solute clearance brain has revealed new mechanism underlying pathogenesis neurodegeneration neuroinflammation. This review presents systematizes current data on causal relationships between dysfunction system accumulation with insufficient excretion toxic metabolic products from functional space neurons, links type.

Язык: Русский

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Is cerebral small vessel disease a central nervous system interstitial fluidopathy?

IBRO Neuroscience Reports, Год журнала: 2023, Номер 16, С. 98 - 105

Опубликована: Дек. 23, 2023

A typical anatomical congregate and functionally distinct multicellular cerebrovascular dynamic confer diverse blood-brain barrier (BBB) microstructural permeabilities to conserve the health of brain parenchymal its microenvironment. This equanimity presupposes glymphatic system that governs flow clearance metabolic waste interstitial fluids (IF) through venous circulation. Following introduction concept, various studies have been carried out on cerebrospinal fluid (CSF) IF dynamics. These reported onset multiple diseases can be attributed impairment in system, which is newly referred as central nervous (CNS) fluidopathy. One such condition includes cerebral small vessel disease (CSVD) with poorly understood pathomechanisms. CSVD an umbrella term describe a chronic progressive disorder affecting microvasculature (or microcirculation) involving penetrating vessels supply white deep grey matter. review article proposes form "CNS fluidopathy". Linking CNS fluidopathy will open better insight pertaining perivascular space dynamics pathophysiology. may lead development treatment therapeutic strategies ameliorate pathology adverse effect CSVD.

Язык: Английский

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Moderating effect of education on glymphatic function and cognitive performance in mild cognitive impairment

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Май 2, 2024

Objective This research aims to investigate putative mechanisms between glymphatic activity and cognition in mild cognitive impairment (MCI) analyzes whether the relationship reserve (CR) was mediated by activity. Methods 54 MCI patients 31 NCs were enrolled evaluate bilateral diffusivity along perivascular spaces acquire an index for space (ALPS-index) on diffusion tensor imaging (DTI). The year of education used as a proxy CR. ALPS-index compared two groups correlation analyses among ALPS-index, function, CR conducted. Mediation applied correlations CR, cognition. Results group had significantly lower right whole brain but higher y-axis projection fiber area (Dyproj) than NCs. In group, left Dyproj negatively related test scores positively correlated with analysis demonstrated that partially function. Conclusion exhibited decreased has protective effect against decline MCI, this may be changes

Язык: Английский

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Fluid movement in the healthy and diseased brain

Neurobiology of Disease, Год журнала: 2023, Номер 182, С. 106168 - 106168

Опубликована: Май 23, 2023

Язык: Английский

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