Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 23, 2023
Abstract
One
of
the
main
hallmarks
Parkinson’s
disease
(PD)
is
abnormal
alpha-synuclein
(α-syn)
aggregation
which
forms
component
intracellular
Lewy
body
inclusions.
This
short
report
used
α-syn
fibrils,
as
well
an
A53T
mutant
adenovirus
to
mimic
conditions
pathological
protein
in
dopaminergic
human
derived
SH-SY5Y
neural
cells.
Since
there
evidence
that
mTOR
pathway
and
glutamatergic
signaling
each
influence
aggregation,
we
also
assessed
impact
inhibitor,
rapamycin
mGluR5
allosteric
modulator,
CTEP.
We
found
both
CTEP
induced
a
significant
reduction
fibrils
cells
this
effect
was
associated
with
factors
(consistent
enhanced
autophagic
activity).
These
data
support
possibility
(or
rapamycin)
might
be
useful
pharmacological
approach
target
accumulation
by
promoting
degradation
or
clearance.
Cells,
Год журнала:
2023,
Номер
12(12), С. 1599 - 1599
Опубликована: Июнь 10, 2023
Apathy
is
commonly
defined
as
a
loss
of
motivation
leading
to
reduction
in
goal-directed
behaviors.
This
multidimensional
syndrome,
which
includes
cognitive,
emotional
and
behavioral
components,
one
the
most
prevalent
neuropsychiatric
features
Parkinson’s
disease
(PD).
It
has
been
established
that
prevalence
apathy
increases
PD
progresses.
However,
pathophysiology
anatomic
substrate
this
syndrome
remain
unclear.
seems
be
underpinned
by
impaired
anatomical
structures
link
prefrontal
cortex
with
limbic
system.
can
encountered
prodromal
stage
fluctuating
patients
receiving
bilateral
chronic
subthalamic
nucleus
stimulation.
In
these
stages,
may
considered
disorder
embodies
amotivational
combined
dopaminergic
serotonergic
denervation
dopa-responsive.
contrast,
advanced
patients,
cognitive
announces
decline
dementia,
diffuse
neurotransmitter
system
dysfunction
Lewy
pathology
spreading
no
longer
review,
we
discuss
clinical
patterns
their
treatment,
neurobiological
basis
apathy,
potential
role
involved
pathways
motivational
apathy.
Brain Sciences,
Год журнала:
2025,
Номер
15(1), С. 41 - 41
Опубликована: Янв. 3, 2025
Background:
Parkinson's
disease
(PD)
is
a
neurodegenerative
disorder
marked
by
motor
deficits
and
non-motor
symptoms,
such
as
depression,
which
are
associated
with
dopaminergic
loss
α-synuclein
aggregation
in
the
brain.
Objectives:
This
study
investigated
neuroprotective
effects
of
hydroalcoholic
extract
purple
fruit
Eugenia
uniflora
(PFEU)
on
ability
depressive-like
behaviors
PD
model
induced
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)
female
Wistar
rats.
Methods:
Rats
received
intranasal
administration
MPTP
or
vehicle,
followed
14
days
oral
PFEU
(300
2000
mg/kg,
administered
once
daily)
vehicle.
Depressive-like
behavior
was
assessed
using
splash
forced
swimming
tests,
while
evaluated
rotarod
open
field
tests.
On
day
15,
hippocampal
tissue
collected
for
immunoreactivity
analysis.
Results:
treatment
behavior,
significantly
reversed
PFEU,
evidenced
increased
grooming
decreased
immobility.
No
coordination
locomotion
were
observed.
Furthermore,
prevented
MPTP-induced
increase
α-synuclein,
p-p53,
Bax
restoring
Bcl-2
levels,
suggesting
through
modulation
apoptotic
pathways
α-synuclein.
Conclusions:
These
findings
support
PFEU's
potential
agent
rats,
highlighting
its
molecular
mechanisms.
World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(3)
Опубликована: Фев. 26, 2025
Parkinson's
disease
(PD)
is
a
common
neurodegenerative
disorder
with
increasing
incidence
and
disability
rates
globally,
placing
heavy
burden
on
patients
their
families.
In
the
prodromal
phase
of
PD,
nonmotor
symptoms,
particularly
depression
sleep
disorders,
are
frequent,
profound
effects
progression
patient
quality
life.
Emerging
research
highlights
critical
role
inflammatory
markers-including
interleukins
tumor
necrosis
factor-in
pathogenesis
PD.
These
mediators
participate
in
processes
may
induce
or
exacerbate
depressive
symptoms
disorders
by
disrupting
function
hypothalamic-pituitary-adrenal
axis
affecting
neurotransmitter,
including
serotonin,
metabolism.
Understanding
correlations
PD
remains
incomplete,
limiting
our
ability
to
develop
targeted
interventions.
This
comprehensive
review
aims
investigate
specific
between
markers
symptoms-particularly
disorders-in
The
findings
could
have
important
practical
applications,
potentially
leading
development
new
diagnostic
tools
therapeutic
strategies
for
managing
By
identifying
understanding
these
correlations,
healthcare
providers
better
predict
implement
more
effective
treatments
Cells,
Год журнала:
2024,
Номер
13(15), С. 1265 - 1265
Опубликована: Июль 27, 2024
Parkinson's
disease
(PD)
is
a
common
multisystem
neurodegenerative
disorder
affecting
1%
of
the
population
over
age
60
years.
The
main
neuropathological
features
PD
are
loss
dopaminergic
neurons
in
substantia
nigra
pars
compacta
(SNpc)
and
presence
alpha
synuclein
(αSyn)-rich
Lewy
bodies
both
manifesting
with
classical
motor
signs.
αSyn
has
emerged
as
key
protein
pathology
it
can
spread
through
synaptic
networks
to
reach
several
anatomical
regions
body
contributing
appearance
non-motor
symptoms
(NMS)
considered
prevalent
among
individuals
prior
diagnosis
persisting
throughout
patient's
life.
NMS
mainly
includes
taste
smell,
constipation,
psychiatric
disorders,
dementia,
impaired
rapid
eye
movement
(REM)
sleep,
urogenital
dysfunction,
cardiovascular
impairment.
This
review
summarizes
more
recent
findings
on
impact
deposits
prodromal
emphasizes
importance
early
detection
toxic
species
biofluids
peripheral
biopsies
prospective
biomarkers
PD.
