Early and widespread engagement of the cerebellum during hippocampal epileptiform activity Format: Brief Communication

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 14, 2024

Despite research illustrating the cerebellum may be a critical circuit element in epilepsies, remarkably little is known about cerebellar engagement during seizures. We therefore implemented novel method for repeated imaging of awake, chronically epileptic animals. found widespread changes calcium signals behavioral seizures

Язык: Английский

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Distinct functional classes of CA1 hippocampal interneurons are modulated by cerebellar stimulation in a coordinated manner

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 14, 2024

There is mounting evidence that the cerebellum impacts hippocampal functioning, but impact of on interneurons remains obscure. Using miniscopes in freely behaving animals, we find optogenetic stimulation Purkinje cells alters calcium activity a large percentage CA1 interneurons. This includes both increases and decreases activity. Remarkably, this bidirectional occurs coordinated fashion, line with interneurons' functional properties. Specifically, activated by cerebellar are commonly locomotion-active, while those inhibited rest-active We additionally subsets show altered during object investigations, suggesting role processing objects space. Importantly, these neurons also modulation stimulation: more likely to be activated, rather than inhibited, decreased opposite profile. Therefore, play

Язык: Английский

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Dynamic functional connectivity and gene expression correlates in temporal lobe epilepsy: insights from hidden markov models

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Backgroud Temporal lobe epilepsy (TLE) is associated with abnormal dynamic functional connectivity patterns, but the changes in brain activity at each time point remain unclear, as does potential molecular mechanisms temporal characteristics of TLE. Methods Resting-state magnetic resonance imaging (rs-fMRI) was acquired for 84 TLE patients and 35 healthy controls (HCs). The data then used to conduct HMM analysis on rs-fMRI from an HC group order explore intricate dynamics cognitive impairment (TLE-CI). Additionally, we aim examine gene expression profiles modular using Allen Human Brain Atlas (AHBA) database. Results Five states were identified this study. Compared HCs, TLE-CI exhibited distinct dynamics, including fractional occupancy, lifetimes, mean dwell switch rate. Furthermore, transition probability across significantly different between (p < 0.05). reconfiguration several networks (including high-order default mode network (DMN), subcortical (SCN), cerebellum (CN). a total 1580 genes revealed be TLE, mainly enriched neuronal signaling synaptic function. Conclusions This study provides new insights into characterizing neural defined by may deepen our understanding neurobiological underpinnings TLE-CI, indicating linkage configuration

Язык: Английский

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Increased cerebellar vermis volume following repetitive transcranial magnetic stimulation in drug-resistant epilepsy: a voxel-based morphometry study

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 25, 2024

Voxel-based morphometry (VBM) was applied to explore structural changes induced by repetitive transcranial magnetic stimulation (rTMS) and the relationship with clinical outcomes. Moreover, between each segmented regional gray matter (GM) volume investigated identify circuits involved in rTMS treatment process patients drug-resistant epilepsy (DRE).

Язык: Английский

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Structural and functional alterations in MRI-negative drug-resistant epilepsy and associated gene expression features

NeuroImage, Год журнала: 2024, Номер 302, С. 120908 - 120908

Опубликована: Окт. 28, 2024

Язык: Английский

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Long‐term neuroplasticity in language networks after anterior temporal lobe resection

Epilepsia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Objective Anterior temporal lobe resection (ATLR) is an effective treatment for drug‐resistant epilepsy (TLE), although language deficits may occur after both left and right ATLR. Functional reorganization of the network has been observed in ipsilateral contralateral hemispheres within 12 months ATLR, but little known longer‐term plasticity effects. Our aim was to examine functions up a decade relation cognitive profiles. Methods We examined 24 TLE patients (12 [LTLE]) 10 controls across four time points: pre‐surgery, 4 months, ~9 years post‐ATLR. Participants underwent standard neuropsychological assessments (naming, phonemic, categorical fluency tests) verbal functional magnetic resonance imaging (fMRI) task. Using flexible factorial design, we analyzed longitudinal fMRI activations from post‐ATLR, relative controls, with separate analyses people hippocampal sclerosis (HS). Change profiles correlated long‐term change determine “efficiency” reorganized networks. Results LTLE had increased engagement extra‐temporal regions, better performance linked bilateral activation. Those HS exhibited more widespread activations. RTLE showed outcomes associated these areas. Both groups achieved stability over 9 years, than 50% improving. Older age, longer duration, lower pre‐operative reserve negatively affected performance. Significance Neuroplasticity continues post‐epilepsy surgery RTLE, recovery regions. This adaptive improved outcomes, challenging traditional view localized These findings emphasize need early intervention, tailored counseling, potential continued gains extended post‐ATLR rehabilitation.

Язык: Английский

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ENIGMA in ACAPULCO: Machine Learning Localization of Cerebellar Anatomy in Epilepsy

Epiliepsy currents/Epilepsy currents, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

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Язык: Английский

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