A systematic review of aperiodic neural activity in clinical investigations

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 15, 2024

Abstract In the study of neuro-electrophysiological recordings, aperiodic neural activity – with no characteristic frequency has increasingly become a common feature study. This interest rapidly extended to clinical work, many reports investigating from patients broad range disorders. work typically seeks evaluate as putative biomarker relating diagnosis or treatment response, and/or potential marker underlying physiological activity. There is thus far clear consensus on if and how relates disorders, nor best practices for it in research. To address this, this systematic literature review, following PRISMA guidelines, examines electrophysiological recordings human psychiatric neurological finding 143 across 35 distinct Reports within disorders are summarized current findings examine what can be learned pertains analysis, interpretations, overall utility investigations. Aperiodic commonly reported relate diagnoses, 31 reporting significant effect diagnostic related studies. However, there variation consistency results heterogeneity patient groups, disease etiologies, status arising themes different Overall, variability results, potentially confounding covariates, limitations understanding suggests further needed before established pathological physiology. Finally, series recommendations proposed, based findings, limitations, key discussion topics assist guiding productive future studying Project Repository The project repository contains code & data project: https://github.com/TomDonoghue/AperiodicClinical

Язык: Английский

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Effectiveness of Electroencephalography Neurofeedback for Improving Working Memory and Episodic Memory in the Elderly: A Meta-Analysis

Medicina, Год журнала: 2024, Номер 60(3), С. 369 - 369

Опубликована: Фев. 22, 2024

Background and Objective: Existing evidence indicates the potential benefits of electroencephalography neurofeedback (NFB) training for cognitive function. This study aims to comprehensively review all available investigating effectiveness NFB on working memory (WM) episodic (EM) in elderly population. Material Methods: A systematic search was conducted across five databases identify clinical trials examining impact function healthy individuals or those with mild impairment (MCI). The co-primary outcomes focused changes WM EM. Data synthesis performed using a random-effects meta-analysis. Results: Fourteen (n = 284) were included analysis. findings revealed that associated improved (k 11, reported as Hedges’ g 0.665, 95% confidence [CI] 0.473 0.858, p < 0.001) EM 12, 0.595, 0.333 0.856, elderly, moderate effect sizes. Subgroup analyses demonstrated had positive both EM, not only population (WM: k 7, 0.495, 0.213 0.778, 0.001; EM: 6, 0.729, 0.483 0.976, but also MCI 0.812, 0.549 1.074, 0.503, 0.088 0.919, 0.018). Additionally, sufficient time (totaling more than 300 min) significant improvement 0.743, 0.510 0.516, 0.156 0.876, 0.005); however, such observed groups inadequate time. Conclusions: results suggest is enhancement individuals, particularly when adequate (exceeding provided. These underscore dementia prevention rehabilitation.

Язык: Английский

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EEG biomarkers in Alzheimer’s and prodromal Alzheimer’s: a comprehensive analysis of spectral and connectivity features

Alzheimer s Research & Therapy, Год журнала: 2024, Номер 16(1)

Опубликована: Окт. 24, 2024

Biomarkers of Alzheimer's disease (AD) and mild cognitive impairment (MCI, or prodromal AD) are highly significant for early diagnosis, clinical trials treatment outcome evaluations. Electroencephalography (EEG), being noninvasive easily accessible, has recently been the center focus. However, a comprehensive understanding EEG in dementia is still needed. A primary objective this study to investigate which many characteristics could effectively differentiate between individuals with AD healthy individuals. We collected resting state data from AD, normal cognition. Two distinct preprocessing pipelines were employed reliability extracted measures across different datasets. 41 features. have also developed stand-alone software application package, Feature Analyzer, as toolbox analysis. This tool allows users extract features spanning various domains, including complexity measures, wavelet features, spectral power ratios, entropy measures. performed statistical tests differences age-matched cognitively based on density (PSD), functional connectivity. Spectral ratio such theta/alpha theta/beta ratios showed Theta was higher suggesting slowing oscillations AD; however, connectivity theta band decreased In contrast, we observed increased gamma/alpha ratio, gamma power, AD. Entropy after correcting multiple electrode comparisons did not show groups. thus catalogued AD-specific Our findings reveal that changes certain frequency bands differ The be biomarkers diagnosis measure outcome, possibly target brain stimulation.

Язык: Английский

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Alignments between cortical neurochemical systems, proteinopathy and neurophysiological alterations along the Alzheimer’s disease continuum

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 14, 2024

Two neuropathological hallmarks of Alzheimer's disease (AD) are the accumulation amyloid-β (Aβ) proteins and alterations in cortical neurophysiological signaling. Despite parallel research indicating disruption multiple neurotransmitter systems AD, it has been unclear whether these two phenomena related to neurochemical organization cortex. We leveraged task-free magnetoencephalography positron emission tomography, with a atlas 19 neurotransmitters study alignment interactions between signaling, Aβ deposition, gradients human In patients amnestic mild cognitive impairment (N = 18) probable AD 20), we found that changes rhythmic, but not arrhythmic, signaling relative healthy controls 20) topographically aligned cholinergic, serotonergic, dopaminergic systems. These neuro-physio-chemical alignments severity behavioral impairments. also plaques preferentially deposited along boundaries, mediate how beta-band rhythmic activity maps align muscarinic acetylcholine receptors. Finally, show an independent dataset many manifest asymptomatic stages 33; N 71 controls), particularly Aβ-neurochemical (57.1%) alpha frequency band (62.5%). Overall, present demonstrates expression pathology pre-clinical clinical aligns distribution chemical neuromodulator systems, scaling implications for potential pharmacotherapeutic pathways.

Язык: Английский

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Intracranial substrates of meditation-induced neuromodulation in amygdala and hippocampus

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 10, 2024

ABSTRACT Meditation is an accessible mental practice associated with emotional regulation and well-being. Loving-kindness meditation (LKM), a specific sub-type of meditative practice, involves focusing one’s attention on thoughts well-being for oneself others. has been proven to be beneficial in variety settings, including therapeutical applications, but the neural activity underlying practices their positive effects are not well understood. In particular, it’s difficult understand contribution deep limbic structures given difficulty studying directly human brain. Here, we leverage unique patient population, epilepsy patients chronically implanted responsive neurostimulation device that allow chronic, invasive electrophysiology recording investigate physiological correlates loving-kindness amygdala hippocampus novice meditators. We find LKM-associated changes periodic, aperiodic, features activity. LKM was increase γ (30-55 Hz) power alternation duration β (13-30 oscillatory bursts both hippocampus, two regions mood disorders. These findings reveals nature LKM-induced modulation first-time SIGNIFICANCE STATEMENT rare recordings while participants engage demonstrate induces beta results build previous experienced meditators reveal meditation’s potential noninvasive neuromodulation mechanisms

Язык: Английский

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Resting-State EEG Correlates of Sustained Attention in Healthy Ageing: Cross-Sectional Findings from the LEISURE Study

Neurobiology of Aging, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Characterising time-on-task effects on oscillatory and aperiodic EEG components and their co-variation with visual task performance.

Опубликована: Апрель 24, 2024

Abstract Research on brain-behaviour relationships often makes the implicit assumption that these derive from a co-variation of stochastic fluctuations in brain activity and performance across trials an experiment. However, challenging this assumption, oscillatory activity, as well indicators performance, such response speed, can show systematic trends with time task. Here we tested whether time-on-task explain range between accuracy decision confidence. Thirty-six participants performed 900 two-alternative forced choice visual discrimination task confidence ratings. Pre- post-stimulus spectral power (1-40Hz) aperiodic (i.e., non-oscillatory) components were compared blocks experimental session for behavioural performance. We found effects EEG primarily localised within alpha band, increasing peak frequency decreasing over time, even when controlling contributions. Aperiodic, broadband other hand did not our data set. Importantly, explained variability single-trial reaction times, effectively removed relationships. affect signatures including predictors Our results dissociate alpha-band be away by those remain after accounting it - thereby further specifying potential functional roles human perception.

Язык: Английский

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Theta-phase locking of single neurons during human spatial memory

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 20, 2024

Abstract The precise timing of single-neuron activity in relation to local field potentials may support various cognitive functions. Extensive research rodents, along with some evidence humans, suggests that at specific phases theta oscillations plays a crucial role memory processes. Our fundamental understanding such theta-phase locking humans and its dependency on basic electrophysiological properties the potential is still limited, however. Here, using recordings epilepsy patients performing spatial task, we thus aimed improving our factors modulating human brain. Combining generalized-phase approach for frequency-adaptive estimation time-resolved spectral parameterization, results show strong prevalent phenomenon across medial temporal lobe regions, both during encoding retrieval. Neuronal increased periods elevated power, when clear were present, aperiodic exhibited steeper slopes. Theta-phase was similarly successful unsuccessful memory, most neurons activated similar between Some changed their preferred retrieval, line idea different processes are separated within cycle. Together, these help disentangle how states influence single neurons. This contributes better interactions memory.

Язык: Английский

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Resting-State EEG Reveals Regional Brain Activity Correlates in Alzheimer’s and Frontotemporal Dementia

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Abstract Resting-state EEG records brain activity when awake but not engaged in tasks, analyzing frequency bands linked to cognitive states. Recent studies on Alzheimer’s disease (AD) and frontotemporal dementia (FTD) have found a link between activity, MMSE scores, age, though some findings are conflicting. This study aimed explore regional differences among AD FTD, thereby improving diagnostic strategies. We analyzed recordings from 88 participants OpenNeuro Dataset ds004504, collected at AHEPA General Hospital using Nihon Kohden 2100 device. The used preprocessed recordings, classification algorithms, function assessments (MMSE) identify significant predictors correlations measures variables. revealed that function, show distinct relationships FTD. In AD, scores significantly predicted regions like C3, C4, T4, Fz, with better performance higher power frontal temporal areas. Conversely, age had major influence particularly P3, O1, O2, while did predict activity. P4, Cz, Pz correlated lower function. Thus, the suggest biomarkers can enhance strategies by highlighting different patterns of related

Язык: Английский

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The aperiodic exponent of neural activity varies with vigilance state in mice and men

PLoS ONE, Год журнала: 2024, Номер 19(8), С. e0301406 - e0301406

Опубликована: Авг. 9, 2024

Recently the 1/f signal of human electroencephalography has attracted attention, as it could potentially reveal a quantitative measure neural excitation and inhibition in brain, that may be relevant clinical setting. The purpose this short article is to show depends on vigilance state brain both humans mice. Therefore, proper labelling EEG important improper obscure disease-related changes signal. We demonstrate by comparing results from longitudinal study genetic mouse model for synaptic dysfunction schizophrenia autism spectrum disorders large European cohort with mild Alzheimer's disease patients. comparison shows when corrected there difference between groups, effect disappears not for. In conclusion, more attention should paid during analysis signals regardless species.

Язык: Английский

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