Quantitative evaluation of neuroradiological and morphometric alteration of inferior Fronto-Occipital Fascicle across different brain tumor histotype: an Italian multicentric study DOI Creative Commons
Roberto Altieri, Andrea Bianconi, Stefano Caneva

и другие.

Acta Neurochirurgica, Год журнала: 2025, Номер 167(1)

Опубликована: Март 12, 2025

Abstract Background Inferior Fronto-Occipital Fascicle (IFOF) is a multitasking connection bundle essential for communication and high level mentalization. The aim of the present study was to quantitatively assess its radiological-anatomical-morphometric modifications according different brain tumor histotype. Methods A retrospective multicentric Italian conducted. IFOF reconstructions were calculated both hemispheres each patient diagnosed with Glioblastoma (GBM), Low Grade Glioma (LGG), Brain Metastasis Meningioma using Elements Fibertracking software (Brainlab AG). 3D object fascicle evaluated volume, average fractional anisotropy (FA) length. cerebral healthy hemisphere compared pathological contralateral in Results 1294 patients evaluated. 156 met inclusion criteria. We found significant difference between mean length volume ( p -value < 0.001). Considering GBM subgroup, Student’s t-test confirmed results. In LGG there 2 length, FA (respectively 0.011; 0.021, affected by metastasis (18) showed 0.003 0.02 respectively). No differences meningiomas. Conclusions careful preoperative neuroradiological evaluation brain-tumor interface indispensable plan tailored surgical strategy perform safe effective technique. It depends on histology pattern growth. have mixed component, solid enhancing nodule which accounts displacement peritumoral area an infiltrative/destructive effect fascicle. determine prevalent infiltrative pattern. Metastases dislocation due oedema. Meningiomas do not impact WM anatomy.

Язык: Английский

Quantitative evaluation of neuroradiological and morphometric alteration of inferior Fronto-Occipital Fascicle across different brain tumor histotype: an Italian multicentric study DOI Creative Commons
Roberto Altieri, Andrea Bianconi, Stefano Caneva

и другие.

Acta Neurochirurgica, Год журнала: 2025, Номер 167(1)

Опубликована: Март 12, 2025

Abstract Background Inferior Fronto-Occipital Fascicle (IFOF) is a multitasking connection bundle essential for communication and high level mentalization. The aim of the present study was to quantitatively assess its radiological-anatomical-morphometric modifications according different brain tumor histotype. Methods A retrospective multicentric Italian conducted. IFOF reconstructions were calculated both hemispheres each patient diagnosed with Glioblastoma (GBM), Low Grade Glioma (LGG), Brain Metastasis Meningioma using Elements Fibertracking software (Brainlab AG). 3D object fascicle evaluated volume, average fractional anisotropy (FA) length. cerebral healthy hemisphere compared pathological contralateral in Results 1294 patients evaluated. 156 met inclusion criteria. We found significant difference between mean length volume ( p -value < 0.001). Considering GBM subgroup, Student’s t-test confirmed results. In LGG there 2 length, FA (respectively 0.011; 0.021, affected by metastasis (18) showed 0.003 0.02 respectively). No differences meningiomas. Conclusions careful preoperative neuroradiological evaluation brain-tumor interface indispensable plan tailored surgical strategy perform safe effective technique. It depends on histology pattern growth. have mixed component, solid enhancing nodule which accounts displacement peritumoral area an infiltrative/destructive effect fascicle. determine prevalent infiltrative pattern. Metastases dislocation due oedema. Meningiomas do not impact WM anatomy.

Язык: Английский

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