Glucose metabolism is controlled by non-coding RNAs in autoimmune diseases; a glimpse into immune system dysregulation
Human Immunology,
Год журнала:
2025,
Номер
86(3), С. 111269 - 111269
Опубликована: Фев. 24, 2025
Язык: Английский
Neuroprotective and antioxidant effects of docosahexaenoic acid (DHA) in an experimental model of multiple sclerosis
The Journal of Nutritional Biochemistry,
Год журнала:
2023,
Номер
124, С. 109497 - 109497
Опубликована: Окт. 23, 2023
Язык: Английский
Animal model of multiple sclerosis: Experimental autoimmune encephalomyelitis
Methods in cell biology,
Год журнала:
2024,
Номер
unknown, С. 35 - 60
Опубликована: Янв. 1, 2024
Язык: Английский
Rs205764 and rs547311 in linc00513 may influence treatment responses in multiple sclerosis patients: A pharmacogenomics Egyptian study
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 17, 2023
Multiple
sclerosis
(MS)
is
characterized
by
a
complex
etiology
that
reflected
in
the
lack
of
consistently
predictable
treatment
responses
across
patients
seemingly
similar
characteristics.
Approaches
to
demystify
underlying
predictors
aberrant
have
made
use
genome-wide
association
studies
(GWAS),
with
imminent
progress
identifying
single
nucleotide
polymorphisms
(SNPs)
associated
MS
risk,
disease
progression,
and
response.
Ultimately,
such
pharmacogenomic
aim
utilize
approach
personalized
medicine
maximize
patient
benefit
minimize
rate
progression.Very
limited
research
available
around
long
intergenic
non-coding
RNA
(linc)00513,
recently
being
reported
as
novel
positive
regulator
type-1
interferon
(IFN)
pathway,
following
its
overexpression
presence
two
polymorphisms:
rs205764
rs547311
promoter
region
this
gene.
We
attempt
provide
data
on
prevalence
genetic
variations
at
Egyptian
patients,
correlate
these
patients'
disease-modifying
treatments.Genomic
DNA
from
144
RRMS
was
isolated
analyzed
for
genotypes
positions
interest
linc00513
using
RT-qPCR.
Genotype
groups
were
compared
regards
their
response
treatment;
additional
secondary
clinical
parameters
including
estimated
disability
status
score
(EDSS),
onset
examined
relation
polymorphisms.Polymorphisms
significantly
higher
fingolimod
lower
dimethylfumarate.
Moreover,
average
EDSS
carrying
higher,
whereas
no
correlation
appeared
exist
MS.Understanding
interplay
factors
influencing
pivotal
MS.
One
contributing
patient's
treatment,
well
disability,
may
be
material,
linc00513.
Through
work,
we
propose
partially
drive
inconsistent
MS;
also
draw
attention
towards
approaches,
screening
specific
polymorphisms,
possibly
direct
choices
disease.
Язык: Английский
Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma
Monaza Adeeb,
Lubna Therachiyil,
Safwan Moton
и другие.
International review of cell and molecular biology,
Год журнала:
2023,
Номер
unknown, С. 149 - 171
Опубликована: Янв. 1, 2023
Язык: Английский
The next frontier in multiple sclerosis therapies: Current advances and evolving targets.
European Journal of Pharmacology,
Год журнала:
2024,
Номер
985, С. 177080 - 177080
Опубликована: Ноя. 2, 2024
Язык: Английский
Insight into Early Diagnosis of Multiple Sclerosis by Targeting Prognostic Biomarkers
Current Pharmaceutical Design,
Год журнала:
2023,
Номер
29(32), С. 2534 - 2544
Опубликована: Сен. 1, 2023
Multiple
sclerosis
(MS)
is
a
central
nervous
system
(CNS)
immune-mediated
disease
that
mainly
strikes
young
adults
and
leaves
them
disabled.
MS
an
autoimmune
illness
causes
the
immune
to
attack
brain
spinal
cord.
The
myelin
sheaths,
which
insulate
nerve
fibers,
are
harmed
by
our
own
cells,
this
interferes
with
signal
transmission.
Numbness,
tingling,
mood
swings,
memory
problems,
exhaustion,
agony,
vision
and/or
paralysis
just
few
of
symptoms.
Despite
technological
advancements
significant
research
efforts
in
recent
years,
diagnosing
can
still
be
difficult.
Each
patient's
distinct
due
heterogeneous
complex
pathophysiology
diverse
types
courses.
There
pressing
need
identify
markers
will
allow
for
more
rapid
accurate
diagnosis
prognosis
assessments
choose
best
course
treatment
each
patient.
cerebrospinal
fluid
(CSF)
excellent
source
particular
indicators
associated
pathology.
CSF
contains
molecules
represent
pathological
processes
such
as
inflammation,
cellular
damage,
loss
blood-brain
barrier
integrity.
Oligoclonal
bands,
neurofilaments,
MS-specific
miRNA,
lncRNA,
IgG-index,
anti-aquaporin
4
antibodies
all
clinically
utilised
diagnosis.
In
slew
new
possible
biomarkers
have
been
presented.
review,
we
look
at
what
know
about
molecular
how
they
aid
differentiation
different
forms
options,
monitoring
predicting
progression,
therapy
response,
consequences
during
opportunistic
infections.
Язык: Английский
Ataxin‐1 controls the expression of specific noncoding RNAs in B cells upon autoimmune demyelination
Immunology and Cell Biology,
Год журнала:
2023,
Номер
101(4), С. 358 - 367
Опубликована: Янв. 22, 2023
B
cells
play
a
key
mechanistic
role
in
the
pathogenesis
of
multiple
sclerosis
(MS),
chronic
neurological
disease
central
nervous
system
with
an
autoimmune
etiology.
contribute
to
initiation
and
progression
by
acting
as
professional
antigen-presenting
well
via
secreting
autoantibodies
proinflammatory
cytokines.
We
have
recently
shown
that
polyglutamine
protein
ataxin-1,
which
was
first
linked
movement
disorder
spinocerebellar
ataxia
type
1,
also
acts
master
regulator
B-cell
functions
context
autoimmunity.
In
fact,
ataxin-1-deficient
mice
display
aggravated
manifestation
MS
model
experimental
encephalomyelitis
along
aberrant
functions.
Consistent
this
scenario,
transcriptomic
analysis
Atxn1-null
highlighted
distinct
genetic
signatures
involved
cell
activation,
proliferation
antigen
presentation.
To
further
characterize
we
profiled
noncoding
transcriptome
controlled
ataxin-1
compartment
upon
encephalitogenic
challenge.
show
two
specific
classes
RNAs,
namely,
processed
pseudogenes
intergenic
long
are
differentially
regulated
disease.
Furthermore,
pathway
network
analyses
on
their
putative
protein-coding
gene
targets
found
significant
enrichment
ontologies
related
mitosis,
together
molecular
processes
relevant
such
chitin
metabolism.
Altogether,
these
findings
shed
light
possible
contribution
RNAs
biology
pathogenesis,
establish
immunomodulatory
demyelination.
Язык: Английский
Transcriptome driven discovery of novel candidate genes for human neurological disorders in the telomer-to-telomer genome assembly era
Human Genomics,
Год журнала:
2023,
Номер
17(1)
Опубликована: Окт. 23, 2023
Abstract
Background
With
the
first
complete
draft
of
a
human
genome,
Telomere-to-Telomere
Consortium
unlocked
previously
concealed
genomic
regions
for
genetic
analyses.
These
harbour
nearly
2000
potential
novel
genes
with
unknown
function.
In
order
to
uncover
candidate
associated
neurological
pathologies,
comparative
transcriptome
study
using
T2T-CHM13
and
GRCh38
genome
assemblies
was
conducted
on
published
datasets
eight
distinct
disorders.
Results
The
analysis
differential
expression
in
RNA
sequencing
data
led
identification
336
linked
Additionally,
it
revealed
that,
average,
3.6%
differentially
expressed
detected
assembly
may
represent
false
positives.
Among
noteworthy
findings,
two
were
discovered,
one
encoding
pore-structured
protein
other
highly
ordered
β-strand-rich
protein.
exhibited
upregulation
multiple
epilepsy
hold
promise
as
potentially
modulating
progression
disease.
Furthermore,
an
derived
from
white
matter
lesions
sclerosis
patients
indicated
significant
26
rRNA
genes.
putative
pathology
related
identified
Alzheimer’s
disease,
amyotrophic
lateral
sclerosis,
glioblastoma,
glioma,
conditions
resulting
m.3242
A
>
G
mtDNA
mutation.
Conclusion
results
presented
here
underline
facilitating
discovery
context
Moreover,
demonstrate
value
remapping
superior
assembly.
Numerous
genes,
either
causative
factors
or
elements,
have
been
unveiled,
warranting
further
experimental
validation.
Язык: Английский
The Function of MicroRNAs in Autoimmune Diseases
Science Insights,
Год журнала:
2022,
Номер
40(5), С. 499 - 505
Опубликована: Апрель 30, 2022
MicroRNAs
(miRNAs)
are
a
family
of
non-coding
single-stranded
RNAs
with
length
around
18-25
nucleotides
that
play
critical
role
in
the
control
gene
expression,
cell
proliferation,
differentiation,
and
apoptosis,
as
well
biological
growth
development
illness.
Autoimmune
diseases
group
disorders
characterized
by
tissue
organ
damage
resulting
dysfunction
result
autoimmune
responses.
Numerous
studies
have
discovered
aberrant
expression
certain
miRNAs
may
serve
biomarkers
for
early
detection
these
or
therapeutic
targets.
The
properties
their
significance
illnesses
discussed
this
review.
Язык: Английский